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  • PharmaTutor
    7 April 2013

    REVIEW: SUSTAINED RELEASE DOSAGE FORMS

    ABOUT AUTHOR:
    Abhijeet Welankiwar.
    Govt. College of pharmacy
    kathora naka Amravati (Maharashtra) 444604.
    abhi123welankiwar@gmail.com

    ABSTRACT:
    The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. With many drugs the basic Goal of therapy is to achieve a steady-state blood or tissue level that is therapeutically effective and nontoxic for an extended period of time. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications so as to achieve a measure of control on therapeutic effect in the face of uncertain fluctuations in the in vivo environment in which drug release takes place. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release formulations of the same drug, over which it provides a prolong release of the drug over extended period of time there by giving the better patient compliance and enhanced bioavailability and resulting blood concentration-time profiles of drugs that otherwise suffer from few limitations.

  • Antimicrobial activity of Cymbopogon Species against Human Pathogens
    3 April 2013
    Antimicrobial activity of Cymbopogon Species against Human Pathogens

    ABOUT AUTHOR
    Rudra Sharan Dwivedi *
    Bhopal University,
    Working in RMS Regrow, Pune
    * rudsd1987@gmail.com

  • REVIEW ON ONCOLYTIC VIRUS
    31 March 2013
    REVIEW ON ONCOLYTIC VIRUS

    ABOUT AUTHORS
    Ashwini Dhusiya, Ritu Mahajan,
    Mahakal Inatitute of Pharmaceutical Studies, ujjain
    Madhya Pradesh    .
    *ashwinidhusiya@gmail.com

    ABSTRACT
    Oncolytic virus is a wonderful discovery of 21st century. The basic concept of Oncolytic virus was developed since 1946 but it was not produce its effect properly. Now latest technology and modern biotechnology introduce a very efficient Oncolytic virus. This is a genetically modified virus that can treat various type of cancer with fewer side effects than other treatment of cancer. It follows different mechanism of killing tumor by specifically replication; induction of tissue necrosis factor; activation of immunity and treat incurable cancer even in metastatic stage of cancer so it is also effective in leukemia. Oncolytic virus therapy is undergoing in clinical trial and shows better results.
    This article covers brief knowledge of cancer, Virus and Oncolytic virus. It is helpful to understand history, mechanism, benefits and clinical data of Oncolytic virus. And a summary of marketed product ready to launch in near future.

  • A REVIEW ON MÖSSBAUER SPECTROSCOPY
    28 March 2013
    A REVIEW ON MÖSSBAUER SPECTROSCOPY

    About Authors
    Deepak Kumar Shukla*, Nazia Shahid, Vikas Kumar Alaria
    Rajasthan Pharmacy College, Bhankrota, Jaipur (Raj.)
    *deepakshukla.pharma@gmail.com

    Abstract
    Over the past several years spectroscopy has become the preeminent technique for determining the structure of organic compounds. The study of recoilless nuclear resonant absorption or fluorescence is more commonly known as Mossbauer spectroscopy. From its first origins in 1957, it has grown rapidly to become one of the most important research methods in solid-state physics and chemistry. Mossbauer spectroscopy uses the nuclear properties to get information regarding the environment surrounding the nucleus. This technique is now valid application in diverse fields, such as solid state physics, metallurgy, chemistry and biochemistry. For example, it is possible to use this method for estimating the iron or tin content in ores, alloys and wasters in a non-destructive manner to concentration down to 0.03 percent in a short time of  the order of 10 minutes. The technique can also detect the relative percentage of  different charged states of the same atom, for example fe2+ and Fe3+ present in the material. This is somewhat difficult to get from any other technique.

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  • SURFACTANTS AND ITS APPLICATION IN PHARMACEUTICALS: AN OVERVIEW
    25 March 2013
    SURFACTANTS AND ITS APPLICATION IN PHARMACEUTICALS: AN OVERVIEW

    About Author:
    Dhananjay S Jadhav*
    M.Tech (Pharmaceutical Technology), Division of Pharmaceutical Technology,
    Institute of Chemical Technology, North Maharashtra University, Jalgaon -425001.
    Maharashtra, India
    * dhananjaysjadhav@hotmail.com

    Abstract
    Recently, surfactants have become one of the most important chemical products. They have become a subject of research, and their production and their use are on the increase. This wide range of properties, uses for surfactants in pharmaceutical products and systems is to try and introduce and explain in the subject of this article. Wetting of Solids, Solubilization, Emulsification, Dispersion of solid in solution, Micellization & Detergency all these are properties of surfactant. Surfactants are classified according to their polar head group, the charged head referred as Ionic surfactants and uncharged surfactants are generally referred to as nonionic surfactant. Because of their unique functional properties, surfactants find a wide range of uses in pharmaceutical preparations. These include, depending on the type of product, improving the solubility or stability of a drug in a liquid preparation, stabilizing and modifying the texture of a semisolid preparation, or altering the flow properties of a granulate, thus aiding in the processing of the final tablet dosage form. In addition to their use as excipients to improve the physical and chemical characteristics of the formulation, surfactants may be included to improve the efficacy or bioperformance of the product. The properties of surfactants are such that they can alter the thermodynamic activity, solubility, diffusion, disintegration, and dissolution rate of a drug. Each of these parameters influences the rate and extent of drug absorption. Furthermore, surfactants can exert direct effects on biological membranes thus altering drug transport across the membrane. The overall effect of inclusion of a surfactant in a pharmaceutical formulation is complex and may be beyond those initially intended. Surfactants may reduce the effectiveness of antimicrobials or preservatives included in a formulation.

  • REVIEW - QUALITY CONTROL OF PARENTERAL PRODUCTS
    8 March 2013
    REVIEW - QUALITY CONTROL OF PARENTERAL PRODUCTS

    About Authors:
    Abhijeet Welankiwar*, Sushant Tope
    Government college of pharmacy Amravati
    Kathora naka, amravati (maharashtra) 44460
    *abhi123welankiwar@gmail.com

    ABSTRACT:
    In a pharmaceutical organization a quality control is a fundamental segment that refers to a process of striving to produce a product by a series of measures requiring an organized effort by entire company to eliminate or prevent error at any stage of production. Quality control deals with testing, sampling, specification, documentation, release procedure which ensure that all tests are actually carried out prior to release of material for sale or use. Until its quality judged to satisfactory. This article deals with quality control of parenteral preparation which have 4 basic area that are Sterility, Freedom form Pyrogens, Freedom from particulate matter and leakers. It gives details on each of these 4 Basic areas. The achievement of sterile, non pyrogenic and particulate free parenteral product provides a significant challenge to ingenuity and creativity of parenteral scientist and technologist.

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  • ORAL MUCOADHESIVE DRUG DELIVERY SYSTEMS: A REVIEW
    26 February 2013
    ORAL MUCOADHESIVE DRUG DELIVERY SYSTEMS: A REVIEW

    About Authors:
    Saumya Samanta1, Ranabir Chanda2, Jyotishman Bhattacharya3
    Benagal School of Technology,
    Chuchura, West Bengal, India
    *samantasaumya7@gmail.com

  • COMPARATIVE DISSOLUTION STUDIES FOR ACECLOFENAC MARKETED DOSAGE FORMS
    24 February 2013
    COMPARATIVE DISSOLUTION STUDIES FOR ACECLOFENAC MARKETED DOSAGE FORMS

    About Author:
    Sowjanya.G
    M.pharmacy II year
    Annamacharya college of pharmacy,
    Rajampet, kadapa dist, a.p, india
    Sowji.ces@gmail.com

  • CURRENT CHALLENGES AND FACTORS AFFECTING PRODUCTION PLANNING AND CONTROL IN PHARMACEUTICAL INDUSTRY-A REVIEW
    21 February 2013
    CURRENT CHALLENGES AND FACTORS AFFECTING PRODUCTION PLANNING AND CONTROL IN PHARMACEUTICAL INDUSTRY-A REVIEW

    About Authors:
    Birajdar Shivprasad M.*, Mulaje S.S., Patil B.R., Sorde M.B., Dr.Bhusnure O.G.
    *Maharashtra College of Pharmacy, Department of Quality Assurance, Nilanga-413521,
    Dist. Latur (Maharashtra) India
    *birajdar100@gmail.com

    Abstract:
    Production Planning & Control is an important aspect & separate department for any production oriented pharmaceutical industry. The basic objective of the manufacturing organization is to make the products. Thus the production is the nucleus or the centre of entire business operations. It must be emphasized, however, that on signal system of forecasting, preplanning, planning and control is suited to all industrial enterprises, no matter how well it may meet the needs of this on that special company. PPC functions look after the manufacturing activities.

  • REVIEW ON SUPER BUG (NDM-1)
    17 February 2013
    REVIEW ON SUPER BUG (NDM-1)

    About Author:
    Kambham Venkateswarlu
    Final Year Graduate Student
    Sri Lakshmi Narasimha College of Pharmacy,
    Palluru, Chittoor-517132, Andhra Pradesh, India.
    k.v.reddy9441701016@gmail.com

    ABSTRACT:
    The term superbug is a nonspecific word that is used to describe any microorganism that is resistant to at least one or more commonly used antibiotics. Some authors restrict its use to microorganisms resistant to two or more antibiotics.

    The most common bacteria described as superbug are the following:
    * MRSA (Staphylococcus aureus strains resistant to multiple antibiotics)
    *  VRE (Enterococcus species resistant to vancomycin)
    *  PRSP (Streptococcus pneumonia strains resistant to penicillin)
    *  ESBLs (Escherichia coli and other Gram-negative bacteria resistant to antibiotics such as cephalosporins and monobactams)

    Emerging superbugs may be multiple drug resistant Clostridium difficile, VRSA (vancomycin resistant S.sureus) and NDM Escherichia coli (New Delhi metallo-beta-lactamase resistant E.coli).

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