Review Articles

ABOUT AUTHORS:
Jyotirmoyee Patnaik
Kanak Manjari Institute of pharmaceutical Sciences.
Rourkela, Orissa
patnaik.jyotirmoyee@gmail.com

ABSTRACT:
Morgellons disease is a mysterious skin disorder that was first described more than 300 years ago. The disease is characterized by fiber-like strands extruding from the skin in conjunction with various dermatologic and neuropsychiatric symptoms Morgellons is a disease of skin lesions, where patients’ complain of itching with skin patches, discomfort and a feeling of something rolling under their skin, and finding fibers, whether single or in bunch on the surface of the skin, mostly on exposed areas such as the face, neck, chest, arms and other parts of the body. The signs and symptoms vary in different individuals.

About Authors:
Vishwanadham Yerragunta*, T.Kumara swamy, D.Suman, V.Anusha, Prathima Patil, T. Samhitha
Department of Pharmaceutical Chemistry,
Vishnu Institute of Pharmaceutical Education and Research,
Narsapur, Medak – 502313, A.P.
Vishwanadham.y@gmail.com
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Abstract:
Chalcones are precursor compounds for flavonoids biosynthesis in plants, and they can also be synthesized in laboratory. Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity and good pharmacological actions. Chalcones became an object of continued interest in both academia and industry. Nowadays, several chalcones are used for treatment of viral disorders, cardiovascular diseases, parasitic infections, pain, gastritis, and stomach cancer, as well as like food additives and cosmetic formulation ingredients. However, much of the pharmacological potential of chalcones is still not utilized. The purpose of this review is to describe the recent efforts of scientists in pharmacological screening of synthetic chalcones, studying importance of chalcones, and synthesis of pharmacologically active chalcones and their biological activities.

ABOUT AUTHORS:
Prathima Patil*¹, Tahseen Sameena¹, S.P.Sethy, K.Shailaja¹, P.Mishra^2
1Department Of Pharmaceutical Chemistry, Sushrut Institute of Pharmacy
Taddanpally (V), Pulkal (M), Medak-502293.
²Department Of Pharmacology, Malla Reddy College Of Pharmacy
Maisimaguda, Dhulapalli, Secundrabad-14
pratima.patil0@gmail.com

ABSTRACT:
Though patents are effective tools for promoting innovation and protecting intellectual property in the pharmaceutical sciences, there has been a growing concern that the current scenario of patient and patent is not vivid in developing countries like India. A lot of complications arise when a pharmaceutical firm applies for patent for their product in developing countries. Innovation in global health care needs patent protection as a safeguard, so patent is a must requires item for health care industries. We can say Patent as a fuel for innovation simultaneously it can burn the pocket of economically backward patients in developing countries. But this thing should not happen as both patent and patient needs each other. A friendly relationship should exist between them. In this context we have discussed about various aspect of patent and patient related issue and also about sensible solution for the issue.

ABOUT AUTHOR:
Muhammed Mujahed
Master’s of Science in Biotechnology.
SRTM University.
mujubiotech2011@rediffmail.com

INTRODUCTION:
Drug design is an integrated developing discipline which portends an era of ‘tailored drug’. It involves the study of effects of biologically active compounds on the basis of molecular interactions in terms of molecular structure or its physico-chemical properties involved. It studies the processes by which the drug produce their effects, how they react with the protoplasm to elicit a particular pharmacological effect or response how they are modified or detoxified, metabolized or eliminated by the organism.

Disposition of drugs in individual region of biosystems is one of the main factors determining the place , mode and intensity of their action . The biological activity may be “positive” as in drug design or “negative” as in toxicology. Thus drug design involves either total innovation of lead  or an optimization of already available lead. These concepts are the building stones up on which the edifice of drug design is built up.

The drug is most commonly an organicsmall  molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of small molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design.

ABOUT AUTHORS:
*Rakesh Gupta, Hemant Kumar Sharma, Manvendra Jaiswal, Rajeev Sharma, Narendra Nyola, Dr. Rajesh Yadav
Alwar Pharmacy College, M.I.A. Alwar,
Rajasthan, India 301001
rakeshapcpharma@gmail.com

About Author:
Mohit Dangwal
DIT Faculty of Pharmacy
Dehradun, Uttarakhand
dangwal_mohit@yahoo.in

About Author:
P. Bharath
Department of pharmacology
Teegala Ram Reddy College of Pharmacy
Hyderabad (AP), 500097.
pbharath760@gmail.com

About Authors:
G. Sowjanya*, P. Ramaa Bharathi, Dr.A.M.S.Sudhakar Babu
A.M.Reddy memorial college of pharmacy,
Narasarao Pet.
Sowjanya.gedagamma@gmail.com