Kredent Academy is the unique concept where industry professionals have taken the onus of creating a strong knowledge bank in their area of expertise by bridging the gap between theory and practice and by incorporating the practical mode of imparting training.

About Authors:
S.Pradeep kumar, D.Prathibha, Dr.N.L.Gowrishankar, R.Parthibarajan, L.Matsyagiri
Department of Pharmaceutics, 
Swami Vivekananda Institute of Pharmaceutical Sciences,
Vangapally (V), Yadagirigutta (M), Nalgonda,
Andhra Pradesh, India.

ABSTRACT
The goal of the present investigation was to formulate and evaluate fast dissolving tablets (FDT) of Rosiglitazone maleate. To improve patient compliance, mouth dissolving tablets have emerged as an alternative to conventional dosage forms. Rosiglitazone and Sulfonylurea are given in combination for treatment of type 2Diabetes Mellitus for long term therapy. During this therapy, it is observed that there is uncontrolled increase of blood glucose level, andthe drug undergoes hepatic metabolism. Therefore, mouth dissolving tablets of Rosiglitazone were prepared to overcome this unusual problem and to make use of the inherent advantages of the novel drug delivery system.The tablets were prepared by using direct compression method using Superdisintegrants. Rosiglitazone mouth dissolving tablets containing Cross povidone & Cross carmellose sodium in the ratio 1:1 showed maximum drug release. Formulations were subjected to stability studies. Formulations are stable for 28 days at 40 oC / 75 % RH with insignificant change in the hardness, disintegration time and in vitro drug release pattern.

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Established under the Act Of State Government- “The Rajasthan University Of Health Sciences Act, 2005” (Act No. 1 of 2005)”on 25 day February, 2005, the University aims to disseminate and advance knowledge in medical and health sciences. The University provides academic and research facilities in various streams to the students studying in various Government Colleges (Medical, Dental, Nursing, Pharmacy & Paramedical) and private colleges/institutions affiliated to this University.

About Author: Rinki Verma (Research fellow)
Institute of Medical science (CEMS)
Banaras Hindu University
Varanasi - 221005

Abstract:
Gallbladder cancer is a comparatively rare cancer and has poor outcome due to their anatomy and location. It has peculiar geographical distribution being common in central and South America, central and eastern Europe, Japan and northern India; it is also common in certain ethnic groups e.g. Native American Indians and Hispanics (Kapoor VK, McMichael AJ ,2003. It is fifteen uncommon cancers in the world with high mortality rate. The diagnosis is made very late due to its silent course. The majority of patients have advanced disease at the time of presentation which carries a poor prognosis. The modes of spread of gall bladder carcinoma are direct, lymphatic, vascular, neural, intraperitoneal and intraductal. Ultra Sound, CT and MRI are helpful in diagnosis and staging of the disease. Surgery remains the mainstay of treatment and chemotherapy has a very limited role.

About Author:
Amol.A.Dambal,
Department of Pharmacognosy and Phytochemistry
Govt. College of pharmacy, Kathora naka,
Amravati-444604. (M.S.), INDIA.

ABSTRACT:
The herbal remedies have been employed in various medical systems for the treatment and management of different diseases. The plant Terminalia arjuna has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. The plants contain Arjunilic acid, Triterpine glycosides like Arjunetosides I, II, III, IV, Arjunine and Arjunetein. The bark is rich in Saponnins, natural anti-oxidants (flavonoids-arjunone,arjunolone,leteilin), gallic acid, ellagic acid , phytosterols, rich in minerals like ca,  mg, zn and co, reducing sugars & coloring matter. It has been reported as Cardio tonic, Hepato-protective, Immunomodulatory, Antihyperglycemic, Antihyperlipidemic, Analgesic and Anti-Inflammatory, Antibacterial and Antiulcer properties.The current study is therefore carried out to provide requisite phytochemical and Pharmacological detail about the plant. The plant is cultivated in different parts of India on a small scale at present However; systematic information on different aspects of this species is not available. In this review, an attempt has been made to present this information.

About Authors:
Ms. Shilpa G. Lodha¹,  Vanita Nimje², Ramzan Virani^3
1 Department of Biotechnology,
Agnihotri College of Science, Ram Nagar,
Wardha 442001, India.
² Department of Biotechnology,
Jankievi Bajaj college, Arvi Naka,
Wardha 442001, India.
³ Department of Biology,
Shivramji Moghe College of Science,
Panharkawada- 445 302, India.

Abstract
Many types of Cancer and Malingancy are known, in that Waldenstrom’s macroglobulinemia is rare cancer of an uncommon lymphoproliferative disorder characterized primarily by bone marrow infiltration and IgM monoclonal gammopathy. It should be considered a distinct clinicopathological entity rather than a clinical syndrome secondary to IgM secretion. The concentration of monoclonal IgM can vary widely in Waldenstrom’s macroglobulinemia and it is not possible to define a concentration that reliably distinguishes it from monoclonal gammopathy of undetermined significance (MGUS).  Besides having lots of diagnosis method, there is no single accepted treatment for Waldenstrom’s macroglobulinemia.  Commonly used treatment includes the monoclonal antibody rituximab, sometimes in combination with chemotherapeutic drugs such as chlorambucil, cyclophosphamide, or vincristine or with thalidomide. We have to find out the successful and low cost methods to cure Waldenstrom’s macroglobulinemia.

ANSWERS of Previous PharmaQUIZ-27:

1.A    2.D    3.A    4.D    5.A

6.B    7.C    8.A    9.B    10.A

ENGAGEMENT OF PARA-MEDICAL STAFF ON CONTRACT BASIS AGAINST VACANCIES EXISTING IN PARA -MEDICAL CATEGORY OF NORTHEAST FRONTIER RAILWAY, MALIGAON & ITS DIVISIONS– THROUGH WALK-IN INTERVIEW.

About Authors:
AK Hafeez, MA Akheel, A Ashfaque, NK Meera
Dept of Pharmacy Practice,
VIPS,
Bangalore, India

Abstract
Aim: To study the prescribing pattern for the treatment of Dengue in tertiary care hospital in Bangalore.
Methods: A retrospective study was carried on prescribing pattern of drugs for the treatment of dengue in a tertiary care teaching hospital in Bangalore. This study included hundred patients both male and female in the age group of 1 – 70 years, the prescriptions were analysed for the drug therapy given.
Results:The results show that the most commonly prescribed class of drugs were antipyretic (99%), anti-ulcer (95%), antibiotics (69%) and anti emetic (40%). In addition, supplementary treatment was also observed. 100% of suffered population was treated with IV fluids. Since a specific treatment is not available for Dengue, the patients were treated symptomatically.
Conclusion:This survey highlights the demands for a more specific treatment, lest it leads to another epidemic break in the country.

About Authors:
Ipshita Chattopadhyaya, Ekta Malhotra
Department of Pharmacy,
Jaipur National University,
Jaipur, India

ABSTRACT
⁽¹⁾The developments in column packing technology and suitable equipment paved the way for what is now called High Performance or High Pressure Liquid Chromatography (HPLC). The new technique provided much higher resolution, more accurate quantitative results, as well as shorter analysis times in comparison to the earlier techniques .During the sixties, new theoretical insights accompanied by important. Since its introduction, HPLC has evolved into an indispensable tool in many analytical laboratories and is applied to diverse analytical problems. Actually, HPLC refers to a number of separation techniques that use a liquid mobile phase, or eluent. Troubleshooting HPLC instrumentation and separations require a fundamental understanding of how the instrument functions and how the separation works. ⁽²⁾This article provides a practical guide to common HPLC problems, along with more in-depth information to help the reader understand the relationships between the observed symptoms and the underlying causes. The practical approach presented here is meant to serve as both a troubleshooting guide and an HPLC learning tool.

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ANSWERS of Previous PharmaQUIZ-26:

1.C    2.D    3.D    4.A    5.D

6.B    7.A    8.C    9.B    10.C

SIRO Clinpharm is one of the leading Global Clinical Research Organizations (CROs), offering full scope services conducting clinical trials in the Pharmaceutical, Biotechnology and Medical Devices sectors in compliance with International Standards. We are headquartered in India having global presence in USA, Israel and in Europe at Germany, Czech Republic, Greece, Estonia, Romania, Spain and France.

About Authors:
Kataria Sahil, Aggarwal Ashutosh, Middha Akanksha, Sandhu Premjeet
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan,
INDIA

INTRODUCTION
Diabetes is a chronic (lifelong) disease marked by high levels of sugar in the blood.
There are three major types of diabetes:
•    Type 1 diabetes is usually diagnosed in childhood. Many patients are diagnosed when they are older than age 20. In this disease, the body makes little or no insulin. Daily injections of insulin are needed. The exact cause is unknown. Genetics, viruses, and autoimmune problems may play a role.

•    Type 2 diabetes is far more common than type 1. It makes up most of diabetes cases. It usually occurs in adulthood, but young people are increasingly being diagnosed with this disease. The pancreas does not make enough insulin to keep blood glucose levels normal, often because the body does not respond well to insulin. Many people with type 2 diabetes do not know they have it, although it is a serious condition. Type 2 diabetes is becoming more common due to increasing obesity and failure to exercise.

Hindustan Aeronautics Ltd. (HAL), a Navratna Central Public Sector Undertaking, is a premier Aeronautical Company of South East Asia with 20 Production / Overhaul / Service Divisions and 10 co-located R&D Centres spread across the country.

About Authors:
Sandhu Premjeet¹, 2,Rathore Devashish², Kataria Sahil¹ , Middha Akanksh^1
1Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
² School of Pharmaceutical Sciences, RGPV University campus,
Bhopal, M.P, INDIA

ABSTRACT
The blood – brain barrier (BBB) has always presented a challenge to scientists for brain drug targeting . the BBB evolved in such a way that it protects the brain from various foreign substance such as neurotoxins. This mechanism makes the BBB an insurmountable . This mechanism makes BBB an insurmountable barrier for numerous highly essential drugs , including antibiotics, cytostatics and other CNS active drug Drugs may be administered directly into the CNS or administered systematically (e.g. by intravenous injection) for targeted action in the CNS. The major challenge to CNS drug delivery is the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. Various strategies that have been used for manipulating the blood-brain barrier for drug delivery to the brain include osmotic and chemical opening of the blood-brain barrier as well as the use of transport/carrier systems. Other strategies for drug delivery to the brain involve bypassing the BBB. Various pharmacological agents have been used to open the BBB and direct invasive methods can introduce therapeutic agents into the brain substance. It is important to consider not only the net delivery of the agent to the CNS, but also the ability of the agent to access the relevant target site within the CNS. Various routes of administration as well as conjugations of drugs, e.g. with liposomes and nanoparticles are considered. Some routes of direct administration to the brain are non-invasive such as transnasal route whereas others involve entry into the CNS by devices and needles such as in case of intrathecal and intracerebroventricular delivery.

About Authors:
Anil kumar
Jubilant chemsys Limited, Noida-201301
Babu Banarsi Das National Institute of Technology and Management
Akhilash Das Nagar, Lucknow

Abstract
Presence of moisture influences chemical stability, crystal structure, powder flow, compaction lubricity, dissolution rate, and polymer film permeability in solid dosage forms and lead to growth of microorganisms, change in thixotropy in semi-solid dosage forms. Moreover, unit operations obviously depending on the amount and state of water present are also influenced by it. Therefore, moisture influences the properties of individual active ingredients and excipients, and it is essential to characterize the effect of moisture on these individual components. This article lay emphasis on determination of moisture by various methods and illustrates the changes induced by moisture on several product and process attributes

ANSWERS of Previous PharmaQUIZ-25:

1.A    2.C    3.C    4.B    5.B

6.C    7.C    8.D    9.C    10.A

The All India Institute of Ayuveda, Sarita Vihar, New Delhi, is a newly established Institute for undertaking multi-disciplinary research and teaching in related subjects for standardization, quality control and scientific validation of Ayurveda drugs and therapies.
The Institute is headed by a Director, the post of which carries the pay scale of Rs.37400-67000- NPA (PB- 4 Grade Pay Rs. 12000) plus allowances like H.R.A., T.A. etc as admissible.