About Authors:
Singh khushboo, Sharma monica,
Ram gopal college of pharmacy,
Gurgaon

ABSTRACT
Approximately 40% of new drug candidate have poor water solubility and oral delivery of such drug is frequently associated with implications of low bioavailabilty,high inter and intra subject variability, lack of dose proportionality. Bioavalibilty of lipophilic drug can be solved by formation of self emulsifying drug delivery system.SEDDS are belongs to lipid formulation and size range is from 100nm[SEDDS] less than 50nm[SMEDDS] and contain a isotropic mixture of oil, surfactant and co surfactant which are emulsified in aqueous media under condition of gentle agitation. The theory behind dissolution rate improvement by means of SEDDS is the spontaneous development of emulsion in GIT with mild agitation provide by gastric motility, which present the drug in solubilized form,small size of formed droplet provided a large inter facial area for absorption,due to small globule size thAT can be easily absorb through lymphatic pathway, thereby passing hepatic pathway.

About Authors:
Prashant L. Pingale, Anjali P. Pingale  
Department of Pharmaceutics & Quality Assurance,
School of Pharmacy and Technology Management, NMIMS Shirpur Campus
Shirpur Dist: Dhule Maharashtra
INDIA 425405.

ABSTRACT:
Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial.
Drug release in the human body can be measured ‘in-vivo’ by measuring the plasma or urine concentrations in the subject concerned. However, there are certain obvious impracticalities involved in employing such techniques on a routine basis. These difficulties have led to the introduction of official ‘in-vitro’ tests which are now rigorously and comprehensively defined in the respective Pharmacopoeia.
Although initially developed for oral dosage forms, the role of the dissolution test has now been extended to ‘drug release’ studies on various other forms such as topical and transdermal systems and suppositories.

ANSWERS of Previous PharmaQUIZ-12:

1.C    2.C    3.B    4.B    5.D

6.A    7.C    8.B    9.D    10.A

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India.

Cadila Pharmaceuticals Ltd., one of the largest Indian pharmaceutical companies has presence in 90 countries across the globe catering to over 45 therapeutic areas. The company has one of the best R&D setup in India which forms the backbone of our state-of-the-art manufacturing facilities in India and abroad, approved by various regulatory authorities including USFDA, MHRA (UK).

Candidates who possess the qualification mentioned below may attend the WALK IN INTERVIEW on 05.12.2011 between 9.00 AM to 12.00 PM with all original certificates, including community certificate and recent passport size photograph. The selected candidates will be working under the DBT project entitled “Characterization of the bacterial toxins isolated from soil samples for the control of mosquito vectors”.

Health biotech is a company that promises good health for all by providing quality medicines at affordable prices and committed to care the people for keeping good health. Health Biotech has won many accolades in the domestic and international pharmaceutical domain.

About Authors:
Kataria Sahil,Middha Akanksha, Sandhu Premjeet
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA

ABSTRACT
Method validation is the process used to confirm that the analytical procedure employed for a specific test is suitable for its intended use. Results from method validation can be used to judge the quality, reliability, and consistency of analytical results; it is an integral part of any good analytical practice. When extended to an analytical procedure, depending upon the application, it means that a method works reproducibly, when carried out by same or different persons, in same or different laboratories, using different  reagents,  different  equipment etc.  In  this  review  article  we  discussed  about  the  strategy  and  importance  of  validation  of  analytical  methods.

About Authors:
D.Ramadevi and S.Ganapaty*
Department of Pharmacognosy and Phytochemistry,
College of Pharmaceutical Sciences, Andhra University,
Visakhapatnam -530 003, India

Abstract
The fusidic acid(ent-16α-acetoxy-3β-dihydroxy-4β,8β,14α-trimethyl-18-nor-5β,10α-cholesta-(17z)-17(20),24-dien-21-oic acid) together with known compounds β-sitosterol, 2-methylanthraquinone, scopoletin, betulinic acid, corchoroside –A and cannogenol  from  the root extract of Corchorus olitorius. Out of these compounds, 2 - methyl anthraquinone and fusidic acids were new to the genus Corchorus and reported for the first time from C.olitorius. The triterpenoid antibiotic fusidic acid was  obtained earlier from a fungi (Fusidium coccineum) , is now reported from the plant C.olitorius.  Occurance  of coumarins in Corchorus genus are rare, but the author could isolate scopoletin, a coumarin from this species.

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India.

IIP is located on 6 acres of land at village Sadavali, about 3 Kms from Devrukh city. The campus includes Administrative area, Instructional Area, Laboratories, Library and Residential buildings etc. in an area admeasuring 5000 Sq.Mtrs. This Institution is a fully developed residential Pharmacy Institute. At present there are over 100 students studying in the Institute.

Established in 1978, "Cachet Pharmaceuticals Pvt. Ltd" is engaged in the manufacturing and marketing of finished pharmaceutical formulations & nutraceuticals in, INDIA and Overseas. The group company ranks among the top 5 pharmaceutical companies in the Indian Pharmaceutical Industry.

Institute of Genomics & Integrative Biology (IGIB), one of the premier constituent establishments of Council of Scientific and Industrial Research (CSIR), is carrying out research and development in the areas of genomics, molecular medicines, bioinformatics and environmental biotechnology. The Institute has played pivotal role in genomics and integrative biology through R & D partnerships and in collaboration with medical institutes, universities and the industry.

Tech Mahindra is part of the US $7.1 billion Mahindra Group, in partnership with British Telecommunications plc (BT), the world’s leading communications service provider. Focused primarily on the telecommunications industry, Tech Mahindra is a leading global systems integrator and business transformation consulting organization.

ANSWERS of Previous PharmaQUIZ-11:

1.D    2.D    3.B    4.D    5.A

6.C    7.A    8.B    9.D    10.C

About Authors:
Dr. A. K. Pathak, Parul Sengar, Kamlesh Kumar*
Department of Pharmacy, Barkatullah University
Bhopal, M. P.

Abstract
A Quantitative Structure Activity Relationship study on a Series of 40 molecules of (4-Quinolylhydrazone compounds) with anti-tubercular activity analogues was made using combination of various physicochemical descriptors (Thermodynamic, electronic and spatial). Several statistical expressions for 2D QSAR & 3D QSAR were developed using stepwise partial least square (PLS) regression analysis and K-Nearest neighboring molecular field analysis (K-NNMFA) respectively. The studies on 2D-QSAR, suggested the four descriptors T_C_C_2, T_C_N_4, Surface area excluding P & S, SsCH3E-index, and H donor count were common and highly contributed the activity. 2DQSAR model developed using partial least square regression approach. Negative logarithmic value of (MIC) was taken as dependent variable and selected discriptors were taken as independent varable. The analysis resulted in the following 2D-equation suggest that, MIC50 = [+0.1587 T_C_C_2- 0.0593 SsCH3E-index- 0.1395 T_C_N_4+ 0.3888 H-Donor Count -3.1556], n =26; Degree of freedom = 22; r² = 0.75; q² = 0.67; F test = 22.63;  r² se = 0.20 ; q² se = 0.23; pred_r² = 0.46 ; pred_r² se = 0.24, a H-donor group at Ar, is important for guiding the design of a new molecule. 3DQSAR model developed using K-nearest neighbour method (training set =33 and test set = 7). The best model derived by the method have q2 = 0.51, q2_se = 0.25, Predr2 = 0.71, pred_r2se = 0.16, n=33, k Nearest Neighbor is 2, Degree of freedom =28. The steric and electrostatic descriptors at the grid points, E_916 (0.1865, 0.3006); S_591 (-0.2851, -0.2580); S_1027 (-0.3273, -0.3090); S926 (30.000, 30.000) plays important role for design of new molecule. 3DQSAR analysis of series of 4-Quinolylhydrazone compounds informed that electropositive and less bulky group increases the biological activity.

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ANSWERS of Previous PharmaQUIZ-10:

1.D    2.A    3.C    4.A    5.A

North-Eastern Hill University was set up by an Act of Parliament and notified on 19th July 1973.

NATIONAL BRAIN RESEARCH CENTRE (NBRC), Manesar-122 050, Gurgaon, requires a Junior Research Fellow in the project funded by Department of Biotechnology, Govt of India

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