Review Articles

About Authors:
Mr. Satyanand Tyagi*, Patel Chirag J¹, Asheesh Singh²
*President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 52 Publications (44 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 52 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
*sntyagi9 @yahoo.com, +91-9871111375 / 9582025220

ABSTRACT:
Prior studies have suggested that depressed people with evidence of high inflammation are less likely to respond to traditional treatments for the disorder, including anti-depressant medications and psychotherapy. This study was designed to see whether blocking inflammation would be a useful treatment for either a wide range of people with difficult-to-treat depression or only those with high levels of inflammation. The study employed infliximab, one of the new biologic drugs used to treat autoimmune and inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. A biologic drug copies the effects of substances naturally made by the body's immune system. In this case, the drug was an antibody that blocks tumour necrosis factor (TNF), a key molecule in inflammation that has been shown to be elevated in some depressed individuals. Study participants all had major depression and were moderately resistant to conventional antidepressant treatment. Each participant was assigned either to infliximab or to a non-active placebo treatment. When investigators looked at the results for the group as a whole, no significant differences were found in the improvement of depression symptoms between the drug and placebo groups. However, when the subjects with high inflammation were examined separately, they exhibited a much better response to infliximab than to placebo.

About Authors:
Kapil Sharma*, Priyanka sharma
*Yaresun Pharmaceutical Pvt Ltd, Jaipur, India
*pharma_kapil@rediffmail.com

INTRODUCTION
Gas chromatography is a widely used technique for the separation of gaseous and volatile sub which are difficult to separate.The primary limit of s technique is that sample must be capable of being volatilized without undergoing decomposition because of this this technique is replaced by H.P.L.C.It is similar to column chromatography except that the gas is used as the mobile phase instead of the liquid.Here gas as a mobile phase or moving phase is passed through a column a column containing liquid adsorbent coated on inert solid support ,thus the adsorption or partition is possible.Gas solid chromatography(G.S.C) based upon the selective adsorption on solid,so the component of  mixture distributes them selves between the gas phase and adsorbent and the separation is due to adsorptive properties.where as Gas liquid chromatography (G.L.C) is based upon partition between Gas and immobile liquid coated on solid,.so the component of  mixture distributes them selves between the gas phase and liquid adsorbent coated on solid and the separation is due to partition properties¹.

[adsense:336x280:8701650588]

About Authors:
Dhiren Shah
m.pharmacy
Seth G.L.Bihani S.D.College of Pharmacy, R.U.H.S.
Sri Ganganagar, Rajasthan, INDIA
dhiren.pharmacist@gmail.com

Abstract
A method has been developed for immobilisation of antisera on fresh plastic tubes through an immunochemical bridge. This type of immobilisation has been shown to be more consistent than direct adsorption on plastic. Such immunochemically coated antisera on plastic tube has been used in the development of a noncentrifugation radioimmunoassay. This assay system has been found to be technically as sound as the conventional method.

About Authors:
Mr. Satyanand Tyagi*, Raghvendra¹, Amlan Mishra², Patel Chirag J³, Asheesh Singh⁴
*President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 51 Publications (43 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 51 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders as well as epilepsy.
¹Department of Pharmaceutics, Aligarh College of Pharmacy, Aligarh, U.P, India-202001.
²Department of Pharmacology, Smt. Vidyawati College of Pharmacy, Jhansi, U.P, India-284128.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
*sntyagi9@yahoo.com, +91-9871111375 / 9582025220

ABSTRACT:
The umbilical blood cord being rich in stem cells needs to be preserved by means of a new technique called cryopreservation. The Process whereby whole tissues or cells are preserved by cooling at very low temperatures is known as Cryopreservation. Stem cell cryopreservation is a relatively new phenomenon; it is one way of ensuring the longevity of child’s health. This is done by banking the baby’s umbilical cord blood affluent with stem cells. Stem cells are important as they can grow into tissues, even organs like the heart or liver. What is more, they have the awesome potential to revamp damaged tissues.

Till date, over seventy diseases have been successfully treated with the help of stem cell stored in the cord blood. Research on stem cells has, by no means, abated. Scientists realizing their potential and worth are carrying out intensive research on their uses as well as ways preservation. Before preserving stem cells, a biological test is carried out to eschew the possibility of deadly diseases like various types of Hepatitis or HIV. That done, the cord blood cells are now stored by means of the technique under discussion- Cryopreservation. This technique involves adding a cryopreservant that lets the blood freeze gradually. The blood is frozen to sub-zero degree temperatures so that biochemical reactions or any other dangerous biological that could cause cell death may be arrested. Typically, the cells are stored at temperatures as low as -196, – 156, or – 120 degrees centigrade. Freezing stem cells through cryopreservation at such low temperatures is supposed to ensure their longevity. Let it be known, however, that scientists are still divided over the optimum temperatures as well as the efficacy of the cryopreservation technique itself. The aim of present article is to provide in depth knowledge about this technique of preserving stem cells of child i.e. the technique so called “Cryopreservation”. An attempt is also made to focus how this technique ensures the longevity of child’s health.

About Authors:
Krunal Parikh^1*, Mr. Maheshkumar Kataria²
(assistant professor, Department of pharmaceutics)
Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
*Krunal_2922@yahoo.in

ABSTARCT :
The word Patent originated from the Latin Word "Patene" which means 'to open'. A patent  is a set of exclusive rights granted by a state (national government) to an inventor or their assignee for a limited period of time in exchange for a public disclosure of an invention.

Under the World Trade Organization's (WTO) Agreement on Trade-Related Aspects of Intellectual Property Rights, patents should be available in WTO member states for any inventions, in all fields of technology, and the term of protection available should be the minimum twenty years. Different types of patents may have varying patent terms(i.e., durations).After 1972  The Act remained in force for about 24 years without any change till December 1994. An ordinance effecting certain changes in the Act was issued on 31 st December 1994, which ceased to operate after six months. Subsequently, another ordinance was issued in 1999. This ordinance was subsequently replaced by the Patents (Amendment) Act, 1999 that was brought into force retrospectively from 1^st January, 1995. The amended Act provided for filing of applications for product patents in the areas of drugs, pharmaceuticals and agro chemicals though such patents were not allowed. However, such applications were to be examined only after 31-12-2004. Meanwhile, the applicants could be allowed Exclusive Marketing Rights (EMR) to sell or distribute these products in India, subject to full filment of certain conditions.

About Authors:
Kishan Singh *, Krishn Kumar Agrawal
Institute of Pharmaceutical Research GLA University,
Mathura-281403 (U.P.) India.
*kishan.singh575@gmail.com

ABSTRACT
Herbal drugs are traditionally used in various parts of the world to cure different diseases. The Ayurvedic and Siddha medical systems are very famous medical practices in Indian traditional medicines. Over the last few ,researcher have aimed at identifying and validation plant derived substance for the treatment of various disease .similarly it has been already proved that various parts of plants such as leaf, fruits seeds etc.provide heath and nutrition promoting compounds traditional used against various disease. Aegle marmelos have been used in ethno medicine to exploit its’ medicinal properties including astringent, antidiarrheal antidysentric, demulcent, antipyretic, and anti-inflammatory activities. The present review aims to complete medicinal values of Aegle marmelos generated through the research activity using modern scientific approaches and innovative scientific tools.

About Author:
Kabita Banik
B.pharm;(WBUT) BCDA College of pharmacy &Technology;
M.pharm(BPUT) Dadhichi college of pharmacy.
banikkabita64@gmail.com

Abstract:
New cancer targeted therapies that make use therapeutic antibodies or small molecules have made treatment more tumor specific and less toxic. Nevertheless, there remain several challenges to the treatment of cancer, including drug resistance, cancer stem cells, and high tumor interstitial fluid pressure. In many solid tumors, for example, increased interstitial fluid pressure makes the uptake of therapeutic agents less efficient. One of the most promising ways of meeting such challenges is ligand-targeted therapy that may be used to make targeting more specific and carry higher dosages of anti-cancer drug to tumor tissue.