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  • HIV / AIDS EVOLUTION AND CONSIDERATIONS

    About Authors:
    Nishant kumar singh
    Research Fellow,
    ICRI (Ahm) and Cranfield University

    * nishantsingh.shree@gmail.com

    ABSTRACT:
    Over 3 decades HIV/AIDS have been a major globally accepted challenge, from endemic to a catastrophic pandemic & explodes globally. Estimates says 33.3 million HIV +ve and 2.6 million newly HIV infected people are in 2009. Since the beginning of epidemic, nearly 30 million people have died from AIDS related cause[1].  From chimpanzees to human[2] and then human to human (migration[3], MSM, HS, IDU, MTC etc) and ultimately it transformed into pandemic. After 30 years we have advanced our treatment & Medicare knowledge of HIV and AIDS. Our scientist has developed several successful targets and drugs based on them, a highly effective therapy HAART currently in use (managing viral load & cell count for better patient survival rate) showing good results. Still HIV/AIDS is incurable, WHY? It shows the need of critical thinking from the very 1st initial step i.e. TARGET. HIV itself is the target; biotech and Pharmaceutical Company must consider nanotechnology & homologous approach for CCR5. Though it seems that we have control over it but if this goes out same way, than one day just due to the HIV typical characteristic of mutation and recombination the worst Catastrophic sub Saharan-Africa epidemic will become Pandemic.[i]

  • A Review Green biotechnology - a help to the environment
    A Review Green biotechnology - a help to the environment

    About Authors:
    Kiran K.Vaghasiya*, Alpesh J.Shiroya
    Bhagwan Mahavir College Of  Biotechnology ,
    Surat
    *vaghasiyakiran51@yahoo.co.in

    Abstract
    Green biotechnologydeals with the use of environmentally-friendly solutions as an alternative to traditional agriculture, horticulture, and animal breeding processes. An example is the designing of transgenic plants that are modified for improved flavor, for increased resistance to pests and diseases, or for enhanced growth in adverse weather conditions. Genetically enhanced crops are one tool that could contribute to a more harmonious balance between food production and our surrounding environment.  The overall message is that biotech plants can, and already do, contribute positively to reducing CO2 emissions and anticipating the impact of climate change on food scarcity. This will increase as they are more widely adopted. This document aims to provide background information about the role green biotech currently plays, and can play in future, in helping to combat climate change.

  • National Innovation Foundation - India (NIF) invites Research Associates/Fellows- 25 Posts
    National Innovation Foundation - India (NIF) invites Research Associates/Fellows- 25 Posts

    National Innovation Foundation - India (NIF), Ahmedabad, a grant-in-aid institute under Department of Science and Technology, Government of India invites applications for following positions in NIF from highly

  • SIMULTANEOUS ESTIMATION OF SILDINAFIL CITRATE AND DAPOXETINE HYDROCHLORIDE FROM COMBINED  PHARMACEUTICAL FORMULATION USING A VALIDATED RAPID RP-HPLC METHOD
    SIMULTANEOUS ESTIMATION OF SILDINAFIL CITRATE AND DAPOXETINE HYDROCHLORIDE FROM COMBINED PHARMACEUTICAL FORMULATION USING A VALIDATED RAPID RP-HPLC METHOD

    About Authors:
    Nirav D.Langhneja1*,
    Tushar  Vaja1, Dr. Vijay K. Parmar2
    1M.Pharm, Department of Pharmaceutical Sciences,
    2Associate Professor,
    Department of Pharmaceutical Sciences,
    Sardar Patel University,

    Vallabh Vidyanagar-388120, Gujarat.
    *laghnejanirav@gmail.com

    INTRODUCTION
    Sildenafil citrate 1-[[3-(6,7-Dihydro -1-methyl- 7-oxo-3-propyl -1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl]sulphonyl]-4-methyl piperazine citrate and it is a popularly known as Viagra .It is a compound of the pyrazolo-pyrimidinyl-methyl piperazine class, and is used to treat male erectile dysfunction (Boolell.M et.al 1996, Morales. A, et.al 1998). It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5  inhibitor. The structural formulae is C22H30N6O4S. It is an ampholyte with pKa value 4 (pirydinium ion) and 8.8 (benzimidazole). Sildenafil citrate is twice as soluble in methanol than in water. Its solubility decreases with pH up to 9 when it starts to increase again. Sildenafil citrate could be determined by several analytical techniques, Densitometry, spectrophotometry, colorimetry, HPLC, GC-MS, MEKC and capillary electrophoresis.

  • Urgently looking for suitable candidate for B.Pharm, M.Pharm, M.Sc for IPR position for R&D dept in API industry - 2 posts
    Urgently looking for suitable candidate for B.Pharm, M.Pharm, M.Sc for IPR position for R&D dept in API industry - 2 posts

    API PLANT AT BARODA

    Post: IPR officer - 2 posts

    [adsense:336x280:8701650588]

  • Gujarat Technological University invites Project Officer (IPR / Patents) | Government job
    Gujarat Technological University invites Project Officer (IPR / Patents) | Government job

    The Gujarat Technological University was established vide Gujarat Act No. 20 of 2007. The main objective of the University apart from other is to develop the knowledge of science, engineering, technology, management and environment for the advancement of quality of life of the mankind in general and in relation to the domain of engineering and technological development and applications.

  • Abbott invites QA Officer Analytical- 4 Posts
    Abbott invites QA Officer Analytical- 4 Posts

    Abbott India Limited is a subsidiary of Abbott Laboratories, USA, a global, iversified health care company devoted to the discovery, development, manufacture and marketing of pharmaceutical, diagnostic, nutritional and hospital products. The company now employs approximately 70,000 people and markets its products in 130 countries worldwide.

  • Work as Polymer Engineer in NEXTUS Solution
    Work as Polymer Engineer in NEXTUS Solution

    NEXTUS SOLUTIONS is a professionally managed organization engaged in offering highly acclaimed consulting, Training and Placement.

  • FORMULATION AND EVALUATION OF OCULAR INSERT OF ACYCLOVIR
    FORMULATION AND EVALUATION OF OCULAR INSERT OF ACYCLOVIR

    About Authors:
    Mistry G. S*, Patel S. D, Tank H. M
    Matushree V. B. Manvar College of Pharmacy
    Dumiyani, Rajkot.
    *Gaurav_mistry123@yahoo.com

    ABSTRACT
    Acyclovir is an Anti-viral drug, widely used in the treatment of Ocular herpes simplex. Ophthalmic insert of acyclovir formulated using Methyl cellulose (MC A4CP), polyvinylpyrrolidone (PVP K30) and polyvinyl alcohol as polymers and glycerin use as plasticizer by solvent casting method with aim of increasing the contact time, achieving sustained release drug. The prepared ophthalmic insert were evaluated for uniformity of thickness, weight uniformity, drug content, % moisture absorption, % moisture loss, folding endurance and surface pH. In vitro drug release of formulated batches was performed using Modified Franz Diffusion cell. A 32 full factorial design was applied to systematically optimize the ocular insert. FTIR spectroscopy was performed to study the drug interaction effect in formulation using KBr disc method. On the basis of all physicochemical parameters and in vitro drug release studies, and overall Desirability, the formulation (F8) was found to vary significantly depending on the type of polymers used and their combinations and it was selected for sterility, stability, ocular irritancy study. The result of invitro diffusion study of formulation exhibited non-fickian in nature. From stability studies inserts were remained stable both physically and chemically. The formulation was found to be practically nonirritant in ocular irritation studies using hen's egg chorioallantoic membrane.

  • BIOSENSOR - Micro electrochemical device
    BIOSENSOR - Micro electrochemical device

    About Authors:
    Vedant M. Pandya
    Department of biotechnology, shree M & N Virani science college,
    Rajkot, India-360005
    vedantpandya007@gmail.com

    ABSTRACT
    A biosensor is a device for the detection of an analyte that combines a biological component with physicochemical detector components. An integrated device consisting of a biological recognition element & a transducer capable of detecting the biological reaction & converting it into a signal which can be processed. Ideally, the sensor shod be self-contained, so that it is not necessary to add reagents to the sample matrix to obtain the desired response. There are a number of analytes which are measured in biological media: pH, partial pressure of carbon dioxide, partial pressure of oxygen & the ionic concentration of sodium, potassium, calcium & chloride. Biosensors are typically classified by the type of recognition element or transduction element employed. Sensors might be described as a catalytic biosensor if it is recognition element comprised an enzyme or series of enzymes, a living tissue slice, or whole cells derived from microorganisms such as bacteria, fungi, or yeast. The sensor might be described as a bioaffinity sensor if the basis of operation were a biospecific complex formation. Accordingly, the reaction of an antibody with an antigen or hapten, or the reaction of an ageist or antagonist with a receptor, could be employed. In the former case, the sensor might be called an immunosensor. Since, enzyme-based sensor measure the rate of the enzyme-catalyzed reaction as the basis for their response, any physical measurement which yield a quantity related to this rate can be used for detection. The enzyme may be immobilized on the end of an optical fiber, & the spectroscopic properties related to the disappearance of the reactants or appearance of products of the reaction can be measured. Since biochemical reaction can be either endothermic or exothermic. Miniaturized thermistor based calorimeter called thermistos, have been developed & widely applied, especially for bioprocess monitoring.

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