Gujarat

About Authors:
Jigar Modi^*1, Dr. Jayvadan Patel¹, Dr. Hitesh chavda^2
1Nootan Pharmacy College, S.P. Sahkar Vidhyadham,
Kamana Crossing, Visnagar-384 315,
Dist – Mehsana, Gujarat, India.
²Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat, India
*jigo_farmacy@yahoo.com

ABSTRACT:
Generally, controlled release dosage forms used in many applications. Superporous hydrogel is also one of them. It has lot of advantages over conventional hydrogel. Superporous hydrogel having faster swelling due to interconnected highly porous structure. Such other properties like slippery property, their mechanical strength and better foaming process are advantageous over conventional hydrogel. Its unique mechanism for achieving gastric retention, a number of hurdles have to be overcome for any approach to be clinically useful. For example, intra-gastric floating systems require the presence of gastric juice to be effective, and this may not be the case in the fasted state. Mucoadhesive systems can easily lose their mucoadhesive properties by interaction with any materials soluble in gastric juice. In this review, types of superporous hydrogel, their preparation, their characterizations and applications are discussed.

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About Authors:
ATUL KABRA^* , PREMAL KAPADIA
Department of Pharmacology,
G.H.B Pharmacy college,
Aniyad, Gujarat
* atul.kbr@gmail.com

ABSTRACT:
The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

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Applications are invited from CSIR-UGC JRF/ ICMR-JRF/ DBT-JRF/ DST inspired fellows for position of JRF in Immunology

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In October 1990 the B. V. Patel Education Trust in conjuncture with the Indian Pharmaceutical Association established B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, in the memory of late Mr. B. V. Patel, the first Drug Controller of Gujarat.

About Author:
ATUL KABRA*, NITIN PATEL
Department of Pharmacology
G.H.B Pharmacy college,
Aniyad, Gujarat
* atul.kbr@gmail.com

ABSTRACT:
The antiulcer effect of aqueous fruit extract of Zizizphus jujuba was studied in ethanol induced ulcer model in rats. The extract dose of 50 mg/kg, 100mg/kg, 200 mg/kgproduced significant inhibition of gastric lesion induced by ethanol. The extarct reduced ulcerative lesion, gastric volume, total acidityin ethanol induced ulcer model.The result obtained suggesting that extract possesses significant antiulcer activity. 

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About Authors:
Pritesh R. Patel^*, Priyank Patel, Jagath Pillai, Nilesh Darji, Bhagirath Patel
Department of Pharmaceutical Chemistry,
Sat Kaival College of Pharmacy, Sarsa,
Ta & Dist: Anand (Gujarat), India-388365
*prit.pharma@gmail.com

ABSTRACT
As part of ongoing studies in developing new antimicrobials, a novel series of 4-acetamido-N-(substituted 1, 3-benzothiazol-2-yl) benzenesulphonamide and N-(substituted 1, 3-benzothiazol-2-yl)-4-(substituted aryl diazenyl) benzenesulphonamide were synthesized in order to determine their antibacterial and antifungal activity. The synthesized compounds were tested in vitro against two Gram-positive bacteria like Staphylococcus aureus, Bacillus subtilis; two Gram-negative bacteria like Escherichia coli, Pseudomonas aeruginosaand one fungal strain Candida albicans in comparison with standard drugs. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antibacterial and antifungal activity against the tested microorganisms. The compounds with a 6-chloro (SK5b), 7-chloro-6-fluoro(SK5d) and 6-nitro (SK5e) on 2-amino benzothiazole ring possessing azo linkage showed better antimicrobial activity; almost similar or less to that of standard drugs thus they could be promising candidates for novel drugs. The novel heterocyclic derivatives were characterized by Physical characterization (Melting point, TLC) and different Spectroscopy techniques (IR, ¹H NMR and Mass spectroscopy).

Atul Ltd is a member of Lalbhai Group, one of the oldest business houses of India, with interests mainly in textiles and chemicals. The Group is strongly committed to serve the society in the fields of education, health as well as culture.