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A REVIEW ON NEW INNOVATIONS AND TECHNOLOGIES IN THE FORMULATION OF ORALLY DISINTEGRATING TABLETS

ABOUT AUTHORS:
YASWANTH ALLAMNENI1*, NAVYA ALLAMNENI2, R AMARNATH1, T RAMASWAMY CHOWDARY1, V SATYANARAYANA1, K VENKATESWARA RAO1

1Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar, Andhra Pradesh – 509228.
2Department of Pharmaceutical Technology, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Guntur,
Andhra Pradesh, India.

*yaswanthallamneni@gmail.com

ABSTRACT
The main aim of this article was to review the development of ODTs, challenges in formulation, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects.Over the past three decades, orally disintegrating tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Orally disintegrating tablets are also called as orodispersible, quick disintegrating, mouth dissolving, fast disintegrating, rapid dissolving tablets, porous tablets, and rapimelts.Orally disintegrating systems have carved a niche amongst the oral drug delivery systems due to the highest component of compliance they enjoy in patients especially the geriatrics and pediatrics. However, of all the above terms, USP approved these dosage forms as ODTs.  These tablets are distinguished from conventional sublingual tablets, lozenges, and buccal tablets which require more than a minute to dissolve in the mouth. According to the recently issued draft guidance for Industry of orally disintegrating tablets, FDA specifically recommends that, in addition to the original definition for an ODT, ODTs be considered solid oral preparations that disintegrate rapidly in the oral cavity, with an in vitro disintegration time of approximately 30 sec or less according to the united states pharmacopoeia (USP) disintegration method or alternative. ODTs release drug in the mouth for absorption through local oromucosal tissues and through pregastric (e.g., oral cavity, pharynx, and oesophagus), gastric (i.e., stomach) and post gastric (e.g. .small and large intestines) segments of the gastrointestinal tract.

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Job as Dy. General Manager (production) in Rajasthan Drugs & Pharmaceuticals - Government of India Enterprise

Rajasthan Drugs & Pharmaceuticals Ltd (RDPL) is profit making Central Public Sector Enterprise. The The Company was formed as a joint venture between Central Government with 51% equity share holding and Rajasthan State Industrial Development and Investment corporation Ltd (RIICO) with 49% equity share holding. Rajasthan Drugs and Pharmaceuticals ltd.(RDPL) was incorporated on 02.11.1978 with the objective to supply life saving and other essential drugs.

Multiple vacancies in AKUMS DRUGS & PHARMACEUTICALS | Require B.Pharm, M.Pharm, B.Sc, M.Sc in DRA, QA, AR&D, FR&D, IPR, stores and more

AKUMS DRUGS & PHARMACEUTICALS LTD is one of the most innovative, productive and research based pioneer organization of India having its registered office at Delhi and various plants in Haridwar, Uttrakhand

Freshers invited as Pharmacist in Krishna Institute of Medical Sciences - 8 Vacancies

Krishna Institute of Medical Sciences (KIMS) welcomes you to the hi-tech hub of Hyderabad. Centrally located on Minister Road, KIMS is where personalised medicare meets modern technology.At KIMS the cream of specialists come together to fulfill a wide range of medical requirements.

Vacancy for CQA Manager in Mankind Pharma

Established in 1995 with a capital of 50 lakhs, Mankind at present is a leading pharmaceutical company of India. Our Goal is to help the community to lead healthy life through two parallel objectives: formulating, developing & commercializing medicines, and delivering affordable & accessible medication that satisfy urgent medical needs.

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Dendrimers: A Novel Therapy for Cancer

About Authors:
Marvinkumar I. Patel*, Ravi R. Patel
Nootan Pharmacy College,
Visnagar,
Gujarat, India

*patel.marvin62@gmail.com

Abstract:
Dendrimer chemistry was first introduced in 1978 by Fritz Vogtle and coworkers. He synthesized the first “cascade molecules”, today known as dendritic molecules. The dendrimer architecture permits control over properties such as shape, size, density, polarity, reactivity and solubility. Dendrimer density functions and starburst limits can be easily modeled mathematically. Dendrimers have stimulated wide interest in the field of chemistry and biology, especially in applications like drug delivery, gene therapy and chemotherapy. A treatment of Cancer mainly focused on the targeting the active drug molecule at the site without affecting the neighbour cells and dendrimers have this property which is useful in diagnosis and treatment purpose which is a new hope in this area of Cancer treatment.

Multiple vacancies for Professor, Associate Professor, Assistant Professor in The Guru Jambheshwar University of Science & Technology - 7 posts

The Guru Jambheshwar University of Science & Technology, Hisar, was established on October 20,1995 by an Act of the Legislature of the State of Haryana with the objectives 'to

Career Opportunity to join in Govt Job as Pharmacist at ZP-Solapur | 2 posts

The Solapur District was ruled by various dynesties such as Andhrabhratyas, Chalukyas, Rashtrkutas, Yadavas and Bahamanis. 'SOLAPUR' is believed to be derived from two words 'SOLA'meaning sixteen and 'PUR' meaning village. Thepresent city of Solapur was considered tp be spread over sixteen villages viz.

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Naprod’s vision is to become a world class player in oncology through excellence in innovation, discovery of new manufacturing processes / drug delivery mechanisms and consistently high quality of production. We commenced operations in 1994 with the inauguration of our ultra-modern facility for the production of generics and formulations for oncology and other therapeutic applications.

QUALITY OF WATER FOR PHARMACEUTICAL USE: AN OVERVIEW

About Authors:
YASWANTH ALLAMNENI1*, NAVYA ALLAMNENI2, P DAYANANDA CHARY1, G VIJAY KUMAR3, ARUN KUMAR KALEKAR1, PAVAN KUMAR POTTURI1
1Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar,Andhra Pradesh – 509228.
2Department of Pharmaceutical Technology, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Guntur, India.
3Principal, A.K.R.G college of Pharmacy, Nallagerla, West Godavari, Andhra Pradesh.

*yaswanthallamneni@gmail.com

ABSTRACT
Water is widely used as a raw material, ingredient, and solvent in the processing, formulation, and manufacture of pharmaceutical products, active pharmaceutical ingredients (APIs) and intermediates, compendial articles, and analytical reagents. This review discusses, primarily from a microbiological aspect, the review and evaluation of high purity water systems that are used for the manufacture of drug products and drug substances. It also includes a review of the design of the various types of systems and some of the problems that have been associated with these systems. As with other guides, it is not all-inclusive, but provides background and guidance for the review and evaluation of high purity water systems. The main objective of this review was to provide guidance to the industry on the pharmaceutical use of different grades of water in the manufacture of active pharmaceutical ingredients and medicinal products for human and veterinary use. This guidance is not intended to cover situations where, for example, medicinal products are prepared extemporaneously or where preparations are reconstituted or diluted with water prior to use by pharmacist (eg. Oral antibiotic mixtures) or in the case of veterinary products by the user (eg. Sheep dips).

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The zilha Parishad of Sangali, The establishment of the Zilla Parishad could be regarded as the culmination point in the achievement of the goal of Local Self-Government. Prior to that, local autonomy was enjoyed in different degrees at the district, taluka and village levels. The Local Self-Governing units were provided by the District Local Board and the village panchayats.

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SKS Group of Institutions (SKSgi) marked its expansion in Mathura with the start of Sanjay College of Pharmacy (SCP). SCP was established in the year 2007 and is located right along the Delhi-Agra NH#2, 125 Km from Delhi, 20Km from Mathura and 12Km from Vrindavan. Approved by AICTE - New Delhi, under Ministry of HRD, the Govt. of India.

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RESISTANCE IN ANTIBIOTICS DEVELOPED : MAINLY USED IN PREGNANCY

About Author:
Shambhavi Singh
B.Pharm (IV) School of Pharmaceutical Science,
Jaipur national university, Jaipur(RAJ.)

*shambhavisingh3111@gmail.com

Abstract
Broad-spectrum antibiotics are prescribed in one third patients for urinary tract infection, and use of third-generation cephalosporins has doubled in the past decade.

Bacteria in pregnancy frequently produce the risk of pyelonephritis, preterm labour, and low birth weight infants. Commonly prescribed antibiotics such as ampicillin (pivampicillin), amoxicillin, fluroqunin, trimethoprim, and sulphonamide are currently associated with development of a high degree of resistance towards most common pathogen responsible for causing urinary tract infection, Escherichia coli. During the past few decades new researches have been made against development of resistance in antibiotic and new drugs are synthesised. The presumption that if a specific drug is safe for the both pregnant woman and the foetus depends on how widely the drug has been used. A recent survey among general practitioners and obstetricians in confirmed that the beta-lactam antibiotic pivmecillinam and ciphalosporins are the most commonly used agents in the treatment of bacteriuria in pregnancy However, a surprisingly high number of physicians reported that they prescribe TMP/SMX during the first two trimesters in spite of resistance of E. coli and possible adverse effects on the foetus.

Opening for Medical Representative ( working in Nephro- Onco Segment need to apply only) in Claris Lifesciences

Claris Lifesciences is one of the largest sterile injectables pharmaceutical companies in India with a market presence in 91 countries worldwide. We primarily manufacture and market products across multiple markets, and therapeutic segments. A significant majority of these products are generic drugs that are capable of being directly injected into the human body and are predominantly used in the treatment of critical illnesses.

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