About Authors: Shahin Shahida, Seema Kathait

Reference ID: PHARMATUTOR-ART-1082

Abstract
In this report, we explored the mechanisms underlying keratinocyte-specific and differentiation-specific gene expression in the skin. We have identified five keratinocyte-specific, open chromatin regions that exist within the 6 kb of 5' upstream regulatory sequence known to faithfully recapitulate the strong endogenous keratin 5 (K5) promoter and/or enhancer activity. One of these, DNase I-hypersensitive site (HSs) 4, was unique in that it acted independently to drive abundant and keratinocyte-specific reporter gene activity in culture and in transgenic mice, despite the fact that it was not essential for K5 enhancer activity. We have identified evolutionarily conserved regulatory elements and a number of their associated proteins that bind to this compact and complex enhancer element. The 125-bp 3' half of this element (referred to as 4.2) is by far the smallest known strong enhancer element possessing keratinocyte-specific activity in vivo. Interestingly, its activity is restricted to a subset of progeny of K5-expressing cells located within the sebaceous gland. The other half of HSs 4 (termed 4.1) possesses activity to suppress sebocyte-specific expression and induce expression in the channel (inner root sheath) cells surrounding the hair shaft. Our findings lead us to a view of keratinocyte gene expression which is determined by multiple regulatory modules, many of which contain AP-2 and/or Sp1/Sp3 binding sites for enhancing expression in skin epithelium, but which also harbor one or more unique sites for the binding of factors which determine specificity. Through mixing and matching of these modules, additional levels of specificity are obtained, indicating that both transcriptional repressors and activators govern the specificity.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.

Central Institute of Medicinal and Aromatic Plants, popularly known as CIMAP, is a frontier plant research laboratory of Council of Scientific and Industrial Research (CSIR).

Banaras Hindu University ranks among the first few in the country in the field of academic and research output. This university has two campuses, 3 institutes, 16 faculties, 140 departments, 4 advanced centers and 4 interdisciplinary schools.

Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna was established in the memory of the First President of Republic of India Deshratna Dr. Rajendra Prasad in the year 1963 with Asthma as its mandate. It was taken over by Indian Council of Medical Research, New Delhi on 1st April, 1984 under Ministry of Health and Family Welfare, Govt. of India and thereafter the main thrust area is Visceral Leishmaniasis (Kala-azar).

The Government of India, through the Ministry of Human Resource Development (MHRD), and based on the recommendation of Scientific Advisory Council to the Prime Minister, decided to create five undergraduate science universities. One of them is located at Kolkata and was started from 2006.

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr. McCarrison as its first Director. It was shifted to Hyderabad in 1958.

Venus start each day by focussing on Innovation & Creativity. We make sure that best healthcare is provided to our patients worldwide.
From a humble beginning in 1991, now we are engaged & engrossed in discovering, developing and delivering innovative pharmaceuticals that help patients to alleviate sufferings.

About Authors: Mayank Panchal1*, Biren Shah1, Krishna Murti1, Megha Shah1
1*Department of Pharmacognosy,
Vidyabharti Trust College of Pharmacy,
Umrakh, (Gujarat) INDIA

Reference ID: PHARMATUTOR-ART-1081

Abstract
Moringa oliefera Lam. is one of the best known and most widely distributed and naturalized species of a monogenetic family Moringaceae. The roots of plant were extracted with ethanol by soxhlet technique and aqueous extract of roots are prepared by maceration technique. Both the extracts are subjected to phytochemical screening. Require quantity of alcoholic and aqueous extracts were obtained from the plant which is used as test drug in Streptozotocin induced diabetic model. The present investigation is undertaken to study the effect of the potential hypoglycemic effect of Moringa oliefera Lam. in Streptozotocin (STZ) induced Diabetes Mellitus.

About Authors: Debojyoti Adak
M.Pharm in Pharmaceutical Chemistry
Seemanta Institute of Pharmaceutical Science, Jharpokharia
Mayurbhanj,
Orissa-757086

Reference ID: PHARMATUTOR-ART-1080

ABSTRACT
Cancer is the leading cause of death worldwide. Chemotherapy is not much safer medication for cancer therapy. Now a day a new technology is developing regarding medication that is nanotechnology. As medication it is well known as nanomedication. It is based on the particle size between 1 nanometer and 100 nanometers. Nanomedicine application areas include drug delivery, therapy, diagonistic, imaging and antimicrobial techniques.This article aims at giving an overview of the present status of nanotechnology in cancer therapy.

20 years Old Bulk Drug Manufacturing company having 3 production facility around chennai.More than 250 employees. USFDA/EDQM Approved, Supllier to almost all major Pharma companies throught the world.Poised for Rapid Growth to become 500 CR + company

Post: Production Chemist

Emcure are fortunate to have a very passionate and talented team. Emcure is committed to emerge as the most preferred employer. We have conducted several training programs and also taken policy decisions towards creating a better work life balance for our people.

Dr. B.R. Ambedkar Center for Biomedical Research (ACBR) was established in March 1991 as part of Centenary celebrations of Baba Saheb Dr. B.R. Ambedkar and its foundation stone was laid by the Hon'ble Prime Minister of India Sh. Chander Shekhar Ji on 31 st March 1991.The mandate of the Centre is postgraduate education and research in Biomedical Sciences.

Meyer, an associate of London based multinational Vitabiotics Ltd.,is a rapidly growing Pharma Co. in India. Leading pharmaceutical manufacturer, founded in 1982 .,in technical collaboration with OMEGA-MEYER Ltd Jersey( Br. Isles). H.O. based in THANE

About Authors: N. V. R. Praveen Kumar. T, Mohanta. G. P, Sudarshan. S# and Parimalakrishnan. S.
Department of Pharmacy, Annamalai University,
Annamalai Nagar – 608002.Tamil Nadu, India.
# Department of Medicine, Rajah Muhtiah Medical College and Hospital, Annamalai University,
Annamalai Nagar – 608002.Tamil Nadu, India.

Reference ID: PHARMATUTOR-ART-1079

Abstract
Objective
The study was conducted to identify and evaluate the Prescription Monitoring of Antihypertensive Drug Utilization for Uncomplicated Hypertension Patients.

Methodology
This was a prospective observational study and was approved by IRB.  The study was conducted in tertiary care teaching hospital, which is located at southern part of India having 1210 beds.  Totally 1262 prescriptions were studied.

Results
Total distribution of patients with respect to age group showed that highest number of patients was found in the age group of 60-69 years (31.3%) and least was found between 20-29 years age group (1.1%). Majority of males in the study population (43.29%) were found to have both the habits of smoking and alcohol. Among concomitant diseases that were related to hypertension Coronary artery disease was highest (67.78%) and giddiness was least (1.7%). In case of diseases unrelated to hypertension Type II diabetes mellitus was observed as highest (38.7%) and acute gastroenteritis was recorded least (5.68%). Overall 43.5% patients were treated with single antihypertensive drug and 53.8% were treated with antihypertensive drug combinations.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output. This university has two campuses, 3 institutes, 16 faculties, 140 departments, 4 advanced centers and 4 interdisciplinary schools.