About Authors:
Ms.Pratibha Chohan*, Mr.Prashant Mutha
B.Pharmacy, G. D. Memorial College of Pharmacy, Jodhpur.
*pmuthabiotech@gmail.com

ABSTRACT:
Brain is tightly segregated from the circulating blood by a unique membranous barrier, the blood – brain barrier (BBB). Many pharmaceuticals cannot be efficiently delivered to, or sustained within the brain; hence they are ineffective in treating a plethora of cerebral diseases. Therefore, drug delivery methods that can provide drug delivery to brain or eventually preferential brain delivery (i.e. brain targeting) are of particular interest. One technique that holds promise for bypassing the BBB to deliver drugs to the brain and eliminating the surgical risk and the spillover effect of drug to normal tissue is the intranasal delivery.

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About Authors:
AMOL D.GHOLAP^*1, DATTATRAY TUPE^2
1Department of Pharmaceutics, Vamanrao Ithape D. Pharmacy College,
Velhale, Tal- Sangamner, Dist- Ahmednagar, MS-422605, India.
²Department of Regulatory Affairs, Lupin Limited,
Kalina, Santakruz (E), Mumbai, MS, India-400098.
*amolgholap16@yahoo.com

Abstract
The several evolutions in the field of medicine develop different cellular mechanisms for striking along with entering the target cells with efficiency. The utilization of recombinenet adenovirus as carriers for cDNA induces dose along with therapy limiting of defense mechanisms. Artificial viral envelopes (AVE) are lipid vesicles which mimic with fusogenic envelop of retrovirus to utilize as target selectivity along with efficiency of delivery of viruses. The major component of AVE includes phosphatidylcholine, phosphatidyiserine along with sphingomyelins. The negative charge is present on AVE’s help them for targeting the moieties such as viral binding proteins. The artificial viral envelopes show potential applications in plasmid delivery.

About Authors:
AMOL D.GHOLAP^*1, DATTATRAY TUPE^2
1 Department of Pharmaceutics, Vamanrao Ithape D. Pharmacy College, Velhale, Tal- Sangamner, Dist- Ahmednagar, MS-422605, India.
² Department of Regulatory Affairs, Lupin Limited, Kalina,
Santakruz (E), Mumbai, MS, India-400098.
*amolgholap16@yahoo.com

Abstracts
There are several newer lipid based systems are evoked and utilized now a days as dryg delivery systems like liposomes, transferosomes, ethosomes etc which provides effective solutions for problem regarding insolubility, instability, rapid degradation along with has wide application in the specialized area consisting protein delivery, targeting to the brain, and tumor targeting. This lipid based systems also utilized in for gene delivery with efficient performance while in this field the colloidosomes evoked as potential tool based on the vascular drug delivery system. There are several applications of vascular systems are present including reduction in the cost of therapy via improved bioavailability of medication generally in the case of poorly soluble drugs. The colloidosomes have several beneficial advantages like greater encapsulation efficiency with wide control on the size along with permeability and compatibility. The colloidosomes also have effective mechanical strength.

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Sigma-Aldrich is a leading Life Science and High Technology company whose biochemical, organic chemical products, kits and services are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical, diagnostics and high technology manufacturing.

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About Authors:
Kapil Sharma^*1, Subhash Gupta^2
1Yaresun Pharmaceutical Pvt. Ltd.,India.
²Oasis test house ltd.jaipur-302006,rajasthan,india.
*pharma_kapil@rediffmail.com

INTRODUCTION
Most of the manufacturing industries rely upon both qualitative and quantitative chemical analysis to ensure that the raw material used meet certain specification, and also to check quality of the final product. The unwanted compound may be harmful to manufacturing process or may appear as a harmful impurity in the final product.¹

A quantitative analysis is performed to establish the proportion of the essential component in the raw material. The final manufactured product is analyzed to ensure that its essential component is present within a predetermined range of composition and impurities do not exceed certain specified limit.

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The Tata Institute of Fundamental Research was conceived and founded by the distinguished Indian Scientist Dr. Homi Bhabha in June 1945 with the active support of the Sir Dorabji Tata Trust and the Government of Bombay Presidency.  In 1962, the Institute shifted to its present picturesque campus at Colaba on the shores of the Arabian Sea.

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