Ranbaxy, India's largest pharmaceutical company having a presence in Anti Infective, Respiratory, Pain Management, Derma, Ortho, Intensive Care, CNS, Oncology, Nephrology, HIV, CV, Urology and Gastro segments in India.
As a part of the expansion drive and ongoing requirements we are looking for young, dynamic and committed Front Line Sales Professionals in Mumbai and rest of Maharashtra.

J. B. Chemicals & Pharmaceuticals Ltd. (JBCPL), known to many as Unique Pharmaceutical Laboratories is one of India's leading global pharmaceutical companies. The company manufactures and markets a wide range of pharmaceutical formulations.

Post:  Officer in Formulation & Development

i3 is a full-service Clinical Research Organization (CRO) focused on five therapeutic areas: Oncology; Cardiology; The Central Nervous System; Respiratory and Infectious Diseases; and Endocrinology and Metabolic diseases. Therapeutic specialization drives all aspects of business in this global CRO - from project staffing and talent management to quality initiatives.

About Authors:
Jyotirmoy Das Choudhury, Dr. Biplab De,
Department of Pharmaceutical Chemistry.
Regional Institute of Pharmaceutical Science and Technology. Abhoynagar, Agartala,
Tripura(W)

INTRODUCTION
Nature always stands as a golden mark to exemplify the outstanding phenomenon of symbiosis. The biotic & abiotic elements of nature are all interdependent. The plants are indispensable to man for his life. The knowledge of drug has accumulated over  thousands of years as a result of man’s inquisitive nature so that today we posses many effective means of ensuring health care.
In the part, almost all the medicines used were from the plants, the plant being men’s only chemist for ages. The history of medical plants dates back to RIG VEDA, perhaps the oldest repository of human knowledge, which was written in about 4500-1600 B.C. then there is the Ayurveda which given us detail accounts of many herbal drugs. Most of the medicinally active substance are identified in the 19^th & 20^th centuries was used in crude form. But now in modern days we use to take drug in the form of dosage form.

About Authors:
Saravana Kumar K, Ramesh Y*,  
Department of Pharmaceutics,
Seshachala College of Pharmacy,
Tirupathi – Chennai High way,  
Puttur-517 583,  Chittoor (dist),
A.P., India

Abstract
Plants and their extracts have immense potential for the management and treatment of wounds. Wound healing is complicated process that involves four phases: (i) coagulation begins immediately after injury, (ii) Inflammation which begins within hours, (iii) Proliferation which begins within days, (iv) Remodeling up to period of week, months, up to year. The phyto medicine for wound healing are not only cheap and affordable but are also purportedly safe as hypersensitive reactions are rarely encountered with the use of these agents. Mainly these crude drugs are obtained from various climatic conditions Collection, cultivating, Harvesting & Isolation of active ingredients to treat various types of diseases.

Govt. of Himachal Pradesh took up initiative in early seventies to set up a CSIR lab to make prudential use of the natural resources of the region.

About Authors:
Ujjwal S. Yeotkar*, Mahendra Nimbhorkar, Tushar A. Deshmukh, Vijay R. Patil
Department of Pharmacognosy,
Tapi Valley Education Society’s,
Hon’ble, Loksevak Madhukarrao Chaudhari College of Pharmacy,
North Maharashtra University,
Faizpur- 425 503,
Maharashtra, India.

ABSTRACT
Churna are important group of formulation used by Ayurvedic physicians to treat various types of diasease. Trikatu and Pimpali churna, as per Ayurvedic literature is used for the treatment of resperatory disorders. In the present study,an attempt has been made to develop a HPTLC  method of quantitative estimation of marker compound, piperine in laboratory prepared authentic formulation and a marketed formulation of Trikatu and Pimpali churna. The stationary phase used was precoated silica gel G ₆₀ F ₂₅₄ plates. The mobile phase containing n- Hexane-ethyl acetate, (5:5 v/v ), was used to separate the spot of Piperine. Plates were developed to a distance of 8 cm at room temperature. Spectrodensitometric scanning was performed by TLC scanner III (CAMAG) in absorbance mode at the wavelength of 339nm. The  R_f  values of  piperine was 0.44± 0.02. The method was validated in terms of Linearity, Accuracy and  Precision. The linearity curve found to be linear in between 200–900 ng/spot. The limit of Detection (LOD) and limit of Quantification (LOQ) were found to be  1 ng and  3 ng respectively. The mean results from % Recovery was found to be, laboratory formulation contain 85.13% and 83.47% while the commercial formulation shows 96.65%, and 90.32% respectively. The proposed method can be used to determine Piperine from Ayurvedic formulations.

About Authors:
Kapil Patel, Supriya Hazra Das
Department of Pharmacology
Shree Dhanvantary Pharmacy College,
Kim, Surat – 394118,
Gujarat, India

Abstract:  
Peptic ulcer is a condition where benign lesions of gastric or duodenal mucosa occur at a site where the mucosal epithelium is exposed to acid and pepsin, due to imbalance between offensive and defensive factors. Acacia leucophloea, a deciduous tree found throughout India is reported to be used in gastric ulcer in traditional medicine. The present study was undertaken to evaluate the anti-ulcer properties of Acacia leucophloea in pylorus ligation ulcer model in rats. Acacia leucophloea was administered for 7 days and on 8^th day 30 min prior to the induction of ulcers. Pretreatment with Acacia leaucophloea showed significant ulcer protection against pylorus ligation ulcer model as compared to control. Thus, the ulcer protective and healing effects of Acacia leucophloea may be due to its effect on both offensive and defensive factors. The present findings suggest that Acacia leucophloea has antiulcer properties.

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

At i3 Global, We believe in science for the sake of people—in the end, it’s about better patient care.
Because we are a service organization through and through, we’ll build a relationship to suit your specialized needs. Tell us what you need and where in the world you want us to be, and we will deliver.

J. B. Chemicals & Pharmaceuticals Ltd. (JBCPL), known to many as Unique Pharmaceutical Laboratories is one of India's leading global pharmaceutical companies. The company manufactures and markets a wide range of pharmaceutical formulations.

Post:  ADL - Officer

Zydus Cadila is a professionally managed public company offering immense opportunities to learn and grow. This ability to evolve, gain new capabilities and raise the bar of excellence forms the heart of our success. We provide an environment where people come and give their best not because they have to, but because they want to. At Zydus we build people to build our business.

Pharmacopoeia Commission for Indian Medicine (PCIM) is an autonomous body established in 2010 with the approval of Govt. of India with an objective to develop Pharmacopoeial standards for Ayurveda, Siddha and Unani drugs and to publish Ayurvedic, Unani and Siddha Pharmacopoeia of India for the promotion of Quality and Safety of ASU Drugs for the furtherance of provisions of Chapter-IV of Drugs and Cosmetics Act-1940 and Rules-1945 of Ayurvedic, Unani and Siddha drugs.

About Authors:
V. Ravi Chandra
Research Associate
Parexel
B.Pharmacy from Priyadarshini College of pharmacy,
Osmania University,
Hyderabad, AP, INDIA

Abstract:
Huntington's disease is an intricate illness. It is a neurodegenerative, insidious disorder-which means it is harmful and fatal but gradually. The onset of the disease is very late to diagnose the disease. Huntington's disease (HD) also called as ‘Huntington’s Chorea’. Chorea means dance in Greek, which is aftereffect of genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. By choreic movement physically we can diagnose HD. HD is also a familial disease, passed from parent to child through a mutation in the normal gene. Attempts to study early disease are not unique in neurology (e.g., mild cognitive impairment and vascular cognitive impairment), but studying otherwise healthy-appearing individuals who have nearly 99% certainty of manifesting the symptoms of brain disease does provide distinct but valuable information about the true natural history of the disease. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. HD occurs in about one out of every 10,000 Caucasian individuals. In India, the cases are unknown because of failure of doctors to diagnose HD as they never seen HD in their practice. Approximately 2.5 times more individuals are at risk for the disorder because of the midlife peak in age at onset.

About Authors:
NIKHIL SAXENA, DR.K.R.PARDASANI, DR.USHA CHAUHAN
MAULANA AZAD NATIONAL INSTITUTE OF TECHNOLOGY,
BHOPAL

ABSTRACT
The electro negativity of the drug directly resembles its chemical nature towards the receptor. In order to achieve the desired response, the effective binding of drug is necessary. Based on the Lock key theory, every drug having a specific structure so that it can bind to a specific receptor. But for designing more efficient a new chemical entity for receptor as compared to the main drug, there is a requirement of some structural changes in the drug (ligand) molecules under structure activity relationship concept. 
Here an attempt has been made to develop Insilco approach to make some structural changes on the basis of point mutation (changes occurs at a particular point) in the antiasthmatic drug namely salbutamol.
The effect of this mutation on binding affinity of the molecule is studied using docking energy (energy involved in orientation of one molecule to a second are when bound to each other to form a stable complex) calculations and logp values. Here eight different structures of the drug found are more electronegative as compared to the main drug candidate. Mutation was made at C-3a position in place of hydrogen. These were analyzed for binding affinity with target receptor. The mutated molecules which have high logp values and less energy are selected for further adme properties studies. Thus after prediction all adme properties and toxicity studies of the mutated drugs, the best mutation was bromine in place of hydrogen at C-3a position.