About Authors:
Bhupender Kumar*, Prof. Sudeep Bhardwaj, Monish Sharma, Ramchandra
Seth G.L. Bihani S.D. College of Technical Education (Institute Of Pharmaceutical Sciences
And Drug Research), Sri Ganganagar, Rajasthan, 335001
*bhupendra.nimiwal@gmail.com
ABSTRACT:
In a typical crossover design, each subject takes each of the treatments under investigation on different occasions. Comparative bioavailability or bioequivalence studies, in which two or more formulations of the same drug are compared, are usually designed as crossover studies. Perhaps the greatest appeal of the crossover design is that each patient acts as his or her own control. This feature allows for the direct comparison of treatments, and is particularly efficient in the presence of large inter individual variation. However, caution should be used when considering this design in studies where carryover effects or other interactions are anticipated. Under these circumstances, a parallel design may be more appropriate.