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ABOUT AUTHORS:
Krupa Mehta, Nitu Changoiwala, Sanjay C. Modi, Dr. Mukesh C. Gohel, Dr. Rajesh K. Parikh
L. M. College of Pharmacy, Navrangpura,
Ahmedabad, Gujarat-380009, India

ABSTRACT:
Objective:
To Formulate, Develop and Optimize fast dispersible oral films of Domperidone maleate.
Materials and Methods:
Fast dispersible films of Domperidone maleate were prepared using solvent casting method. Films were formulated using Hydroxy Propyl Methyl Cellulose (HPMC-E5) as a film forming agent, PEG-400 as a plasticizer. A 3² full factorial design was applied systematically to optimize the drug release and folding endurance. The concentration of HPMC-E5 (X1) and concentration of PEG-400 (X2) were selected as independent variables.
  The Percentage Drug Release in 5 minutes (Y1) and Folding endurance (Y2) were selected as dependent variables. The prepared films were evaluated for Thickness, Folding endurance, Tensile Strength, Disintegration time, In vitro drug release and Drug content uniformity.  DSC studies were conducted for drug-excipient interactions.
Results: Films prepared were found to be of good quality fulfilling all the requirements. Regression analysis and numerical optimization were performed to identify the best formulation. Formulations F10 prepared with 2.7% HPMC-E5 and 20% PEG-400 was found to be the best formulation with 96% Drug release in 5 minutes and folding endurance 24.
Discussion: X₁ and X₂ significantly affected the Percentage Drug Release in 5 minutes (Y1) and Folding endurance (Y2). Percentage Drug Release decreased as the concentration of HPMC-E5 and PEG-400 increased. Folding endurance increased as the concentration of HPMC-E5 and PEG-400 increased.
Conclusions: Fast dispersible films of Domperidone maleate were successfully formulated by Solvent casting technique with immediate onset of action & improved patient compliance.

Jawaharlal Nehru University has been granted funds by the Department of Biotechnology (DBT), Govt.

For more than 20 years, as Albany Molecular Research Inc. (AMRI), we have provided fully integrated drug discovery, development and manufacturing services – all while adapting to the rapidly changing needs of our customers within the pharmaceutical, biotechnology and related industries.

ABOUT AUTHOR:
Raaz K Maheshwari
Department of Chemistry, SBRM PG Govt College,
Nagaur, Rajasthan
drraazgreenchemacs@gmail.com
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ABSTRACT
The use of PPCPs is on the rise on the globe. PPCPs enter into the environment through individual human activity and as residues from manufacturing, agribusiness, veterinary use, and hospital and community use. Individuals may add PPCPs to the environment through waste excretion and bathing as well as by directly disposing of unused medications to septic tanks, sewers, or trash. Because PPCPs tend to dissolve relatively easily and don’t evaporate at normal temperatures, they often end up in soil and water bodies. Some PPCPs are broken down or processed easily by a human or animal body and/or degrade quickly in the environment. However, others do not break down or degrade easily. The likelihood or ease with which an individual substance will break down depends on its chemical makeup and the metabolic pathway of the compound. Varying concentrations of drugs found in water sources can have ill effect on the aquatic life and human health. For pharmaceutical pollution, the solution calls upon all health care sectors to participate in preventing pharmaceutical pollution. Green Pharmacy aims at zero pharmaceutical waste in our environment. It offers an opportunity for social action that will greatly benefit our environment at all levels of our society. It encourages health providers and clients to focus on healthy lifestyle and prevention to ensure their well-being through regular wellness practices. It provides education and opportunity for everyone involved with the life cycle of medicine to participate in reducing pharmaceutical pollution. With relatively simple yet firm commitments to change our habits, becoming stewards of medicine rather than consumers of medicine we effectively become part of the solution. This review paper delineates about the powerful approaches of green pharmacy that provides comprehensive solution to pharmaceutical pollution affecting much of well being on globe. Research to date points to the ubiquity of PPCPs in aquatic environments. Existing wastewater treatment facilities are inadequate and aren’t designed to remove them from the waste stream. Our current system of quantifying their toxicological effects is inadequate. Now is the time to prevent further harm to living organisms and the environment.

Quintiles is the only fully integrated biopharmaceutical services company offering clinical, commercial, consulting and capital solutions worldwide. Our network of 23,000 engaged professionals in 60 countries around the globe works with an unwavering commitment to patients, safety and ethics — ensuring a higher level of healthcare for people. For our biopharmaceutical customers, we help them navigate risk and seize opportunities in an environment where change is constant.

Applications are invited from the eligible candidates in the prescribed format for engagement in the following posts on contractual basis in Mayurbhanj district under NRHM programme. The last date of receipt of the forms by Regd/Speed post/Courier only is on or before 11.11.2013- 5 p.m, “Application for the post _____” should be written in the top of the envelope addressed to the Chief Dist.Medical Officer, Mayurbhanj, At/PO: Baripada otherwise it will be rejected. The applications received after due date/by ordinary post and incomplete manner, non-enclosing of required documents will not be entertained and liable for rejection without any intimation thereof.

Post: Pharmacist-cum-Logistics Assistant, Protocol Manager

Applications are invited from highly motivated candidates sponsored for the following post under CSIR scheme( 3s(1333)/12/EMR-II) entitled "Diversity unexplored analysisa nd documentation of diazotrophic cyanobacteria of chhattisgarh" along with detailed academic biodata (preferably by email) to PI

Post: Research Associate, Senior Research Fellow, Junior Research Fellow

The history of the IIT system dates back to 1946 when a committee was set up by Hon'ble Sir Jogendra Singh, Member of the Viceroy's Executive Council, Department of Education, Health and Agriculture to consider the setting up of Higher Technical Institutions for post war industrial development in India. The 22 member committee headed by Sri N.R.Sarkar, in its report, recommended the establishment of four Higher Technical Institutions in the Eastern, Western, Northern and Southern regions, possibly on the lines of the Massachusetts Institute of Technology, USA, with a number of secondary institutions affiliated to it.

Post: Senior Project Scientist- 1, Project Officer- 1, Project Assistant- 2, Junior Project Assistant- 2

ABOUT AUTHORS:
Edukondalu.Vanka*, M. Jhansi Rani, A.M.Sudhakar Babu, P.Venkatesawara Rao
Department Of Pharmaceutics,
A.M. Reddy Memorial College of Pharmacy,
Narasaraopet, Guntur (district), Andhra Pradesh
7yedu7@gmail.com
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ABSTRACT:
Novel Oral Drug Delivery technologies have emerged and expanded into different drug delivery System. Among them Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. The drug delivery is designed according to the circadian rhythm of body. System is suit for the drugs which shows high first pass effect. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like  Time controlled pulsatile release systems, Stimuli-induced pulsatile release system, Externally regulated pulsatile release system, Multiparticulate regulated pulsatile release system have been dealt with in the article. These delivery occurs at predetermined lag time. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required, such as anti-arhythmic and anti-asthmatic.

Walk-in-Interview will be held on 5th November, 2013 at 04.00 P.M in the Seminar Room of Department of Biophysics, Bose Institute, P-1/12, C.I.T. Scheme VII-M, Kankurgachi, Kolkata- 700054 for one position of Junior Research Fellow in the DBT sponsored project entitled, “Biophysical and Structural Aspects of Oncogenic G-Quartets bound to Drugs: Screening, High Resolution NMR and Low Resolution Spectroscopy(RGYI)”, under the guidance of Dr.

inVentiv Health Clinical, formerly PharmaNet/i3, is a leading provider of global drug development services to pharmaceutical, biotechnology, generic drug, and medical device companies. With 7,000 employees in more than 36 countries, inVentiv Health Clinical offers therapeutically specialized capabilities for all phases of clinical development, bioanalytical services, and strategic resourcing from a single clinical professional to an entire functional team.

Post: Senior Clinical Data Manager

IDPL is the largest Central Pharma Public Sector Undertaking in India with plants at Rishikesh, Gurgaon & Hyderabad and two Subsidiary Units at Chennai and Muzaffarpur. IDPL played a major role in the strategic National Health Programmes like Family Welfare Programme & Population Control (Mala-D & Mala-N) anti-malarials (Chloroquine) and prevention of dehydration (ORS) by providing quality medicines.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output. This university has two campuses, 3 institutes, 16 faculties, 140 departments, 4 advanced centers and 4 interdisciplinary schools.

The vision of NMIMS University is to define the 21st century technological and management research. Hence the goal for NMIMS University is to encourage excellence in research and publication activities. Research is a precursor to discovery and innovation.

Applications are invited on plain paper along with a copy of bio-data and testimonials for the following temporary position (co-terminus with project) in DBT sponsored project.

Post: Junior Research Fellow

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Piramal Life Sciences Limited (PLSL) is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly known as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL. PLSL has state-of-the-art R&D laboratories built over 200,000 square-feet of space in Mumbai, India and over 300 scientists engaged in drug discovery and development.

Bharathidasan Institute of Technology (BIT) has been established as a Technical Institute under Anna University, Chennai by the Government of Tamil Nadu and recently sponsored with Technical Education Quality Improvement Programme (TEQIP) grant. It offers a variety of UG, PG and research programmes with an approximate of 3000 students in the campus.

HLL Lifecare Limited, a Mini Ratna Central Public Sector Enterprise under the Ministry of Health & Family Welfare, Govt. of India is a global provider of high quality healthcare products & services. With state-of-the-art manufacturing facilities spanning across India, HLL is diversifying into vaccine manufacturing, lifecare services, sanitary napkins besides engaging in procurement consultancy, healthcare infrastructure development and facility management.

Post: MICROBIOLOGY ASSISTANT

For over 200 years, we’ve harnessed our scientific expertise to discover, enable, and deliver solutions for the world at large. Explore DuPont careers to discover how we work together with academics, governments, companies and organizations around the globe to find new and better ways to provide for the needs of our growing population. It’s what we call inclusive innovation.

Post: Sales Manager, Dietary Supplements and Pharma