Pharmaceutics Articles

ABOUT AUTHORS:
Rahul Ratnakar*¹, Lakshmi Goswami², Dr. Preeti kothiyal
¹Persuing M.Pharma
²Lecturer/guide
^1,2Shri Guru Ram Rai Institute of Technology & Science,
P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand, India.
rhl.ratnakar@gmail.com

ABSTRACT
Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance ^[1]. Mouth dissolving tablets are solid dosage forms containing drugs that disintegrate in the oral cavity within less than one minute the development of mouth dissolving tablets formulation is emerging and gaining popularity because it is easy to administer and leads to better patient compliance ^[2]. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds’. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab) (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva ^[3]. MDTs can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients. This is seen to afflict nearly 35% of the general population and associated with a number of conditions, like parkinsonism, mental disability, motion sickness, unconsciousness, unavailability of water etc. To overcome such problems, certain innovative drug delivery systems, like ‘Mouth Dissolving Tablets’ (MDT) have been developed ^[4].

About Author:
Vivek P. Chavda
Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
Rajkot – 360003, Gujarat (India)
vivek7chavda@gmail.com

About Authors:
Rawat Smriti*, Bisht Seema, Kothi Yal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India.
*smritirawat000@gmail.com

ABOUT AUTHORS:
Abhishek Shah*, Gautam Singhvi
Department of Pharmacy, Industrial Research Lab,
Birla Institute of Technology and Science,
Pilani, Rajasthan, India., Pin: 333 031
abhishah200291@gmail.com

About Authors:
Arsh Chanana*, Mahesh Kumar Kataria, Ajay Bilandi
Department of Pharmaceutics, Seth. G.L. Bihani S.D. College of Technical Education,
Sri Ganganagar (Rajasthan) INDIA
*arshchanana806@gmail.com

Abstract-
Microcapsule is a tiny sphere including core material/internal phase or fill, coated with/surrounded by wall know as shell, coating or membrane. The usual size range of the microcapsule lies between 1 to 1000 μm. The technique is usually applied for targeted drug delivery, protection of the molecule and stability if the core material. Microencapsulation system offers potential advantages over conventional drug delivery systems and also established as unique carrier systems for many pharmaceuticals. This article contains the traditional and the recent techniques, including their patents, for the preparation of microcapsules. Solvent exchange method, coacervation, polymerization, hot melts etc are several recent techniques are used for the preparation of the microcapsules. The microencapsulation technique, as Novel drug Delivery System (NDDS), is widely applied for delivery of probiotics, drugs, pesticide, food etc. Although significant advances have been made in the field of microencapsulation, still many challenges need to be rectified during the appropriate selection of core materials, coating materials and process techniques.

ABOUT AUTHORS:
S.Shanmugam¹, J. Srikanth Reddy*¹, T. Vetrichelvan²
Adhiparasakthi College of Pharmacy,
Melmaruvathur, 603 319, Tamilnadu, India.
*srikanthjeedipelly@gmail.com

ABSTRCT:
The present study in formulation and evaluation of 5-fluorouracil microcapsules. 5-fluorouracil which is used as a anti cancer drug to treat cancer. The capsules were prepared by coacervation phase separation and emulsion solvent evaporation by using gelatin, sodium alginate and ethyl cellulose. The prepared microcapsules were evaluated with various evaluation methods such as drug content, in-vitro drug release studies, kinetic studies and stability studies as per ICH guidelines were performed. The formulated extended release microcapsules were prepared by powder layering technique. In these formulations containing 150mg of 5-fluorouracil was loaded in it. The particle size and dissolution study of  F9 formulation was concluded as the best formulation among other formulations, which showing the most desired drug release. It will be considered as optimized formulation. No significant change was observed in the drug content physical properties and dissolution rate of these micro pellets after the storage period of three months at 40±2ºc and 75±5%RH.

ABOUT AUTHORS:
R.B.Desireddy, *Sure.Lakshmi Sindhuri, A. Charitha, G.Naga sowjanya
Nalanda institute of pharmaceutical sciences,
kantepudi, Sattenapalli.
*suresindhuri@gmail.com

ABOUT AUTHORS:
Papola Vibhooti *, Dr. Kothiyal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India
*papola.vibhooti47@gmail.com

ABSTRACTS
The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for oramucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelation characteristics and was therefore suitable for the development of the wafer system. Suitable excipient and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.