Pharmaceutics Articles

11 September 2013

DEVELOPMENT AND EVALUATION OF TERBINAFINE HYDROCHLORIDE FOR TABLET FORMULATION

ABOUT AUTHORS:
Dewangan A*, Tomar B, Dr.Mehta P.
Department of Pharmaceutics,
Lakshmi Narain College of Pharmacy, Bhopal-462021
devakash.1850@rediffmail.com

ABSTRACT:
Immediate release tablets prepared by wet granulation method containing drug by using superdisintegrants like Crosscarmellose, Sodium starch glycolate in different concentrations i.e 4.5% and 3% and the selected superdisintegrants were used along with different diluents like microcrystalline cellulose and their combinations. Comparative evaluation of Terbinafine Hydrochloride tablets by wet granulation method as its formulations rapidly disintegrates in the stomach. The in-vitro percentage drug release from the formulation F-8 prepared by wet granulation compression containing Microcrystalline cellulose at concentration of 5% was found to be 99.67% drug release.

11 September 2013

REVIEW ON BETA- CYCLODEXTRIN INCLUSION COMPLEX: A MORDEN APPROACH FOR DRUG DELIVERY

ABOUT AUTHORS:
Bhatt Anjali*, Goshwami Lakshmi, Papola Vibhooti, Pathak Namita, Rawat Shuveksha
Shri Guru Ram Rai Institute of Technology and Science,
Dehradun 248001, Uttrakhand India

6 September 2013

BIO-ANALYTICAL METHOD DEVELOPMENT, VALIDATION AND TRANSFER BY USING LC-MS/MS – A REVIEW

About Authors:
Satya Lakshmi.B*, P.Raju vel, Dr. P. Venkateswara Rao, Sindhu.G, Nikil Kumar.K
A.M Reddy Memorial College of Pharmacy,
Narasaraopet, AN University, Guntur.
balla.satya03@gmail.com

Abstract:
The reliability of quantitative assays in determination of drugs in biological fluids using High-performance liquid chromatography with Tandem Mass spectrometric determination (LC-MS/MS) detection methods and the integrity of resulting Pharmacokinetic data may not be absolute, in contrary to common perceptions and possible conjectures. The results may be adversely affected by lack of specificity and selectivity due to ion suppression caused by the sample matrix and interferences from metabolites. The advancements in the past few years and new technologies introduced can be used in enhancing LC-MS/MS Bio-analytical method development by reducing matrix effects. This Article reviews Automated Sample preparation and various extraction techniques like liquid-liquid extraction, Solid phase extraction and protein precipitation which plays an important role in sample preparation and detection by LC-MS/MS. Potential drawbacks during method development and validation are pointed out.

5 September 2013

FORMULATION AND EVALUATION OF CETIRIZINE HYDROCLORIDE FAST DISSOLVING ORAL FILMS

ABOUT AUTHORS:
*¹Charugundla Harini,² K. Sudheer kumar
¹Kakadiya University, Warangal
²Bijupatnaik University of Technology & Sciences, Odisha
charugundlaharini@gmail.com

ABSTRACT
The aim of present research was to develop a fast releasing oral polymeric film, with good mechanical properties, instant disintegration and dissolution, producing an acceptable taste when placed on tongue. Solvent casting method was used to prepare oral films. cetirizine hydrochloride an antihistaminic was incorporated to relieve the symptoms of allergic rhinitis. The polymers selected were HPMC 3cps and PVA. Glycerin was the plasticizer used. Eight batches of films with drug were prepared using different combinations of polymer concentration. The resultant films were evaluated for weight variation, content uniformity, folding endurance, thickness, surface pH, tensile strength, % elongation, % moisture absorption, %moisture loss in vitro disintegration and in vitro dissolution. The optimized films have disintegrated within 28-60sec. The percentage release was varying with concentration of polymer. The films made with HPMC3cps 200 mg released 98.5% of drug in 2min, which was the best release amongst all.

5 September 2013

COMPARISON OF NEW DRUG APPROVAL PROCEDURES AND REGULATORY STRUCTURES IN TURKEY AND CANADA

About Authors:
Abhisek Shukla*, Dr. Valluru Ravi
Pharmaceutical Regulatory Affairs group, Dept. of Pharmaceutics,
JSS College of Pharmacy, JSS University,
Sri Shivarathreeshwara Nagar, Mysore-570015, Karnataka, India.
abhishekjsscp@gmail.com

3 September 2013

A REVIEW : SELECTION OF DISSOLUTION MEDIA

ABOUT AUTHOR:
Mr. Ripal Mistry
M.pharm, Indubhai Patel College Of Pharmacy & Research Center,
Dharmaj
Rx.ripalmistry@gmail.com

DEFINATION:

30 August 2013

NATURAL POLYMERS USED IN FLOATING DRUG DELIVERY SYSTEM

ABOUT AUTHOR:
Jeevan Menaria*, Rahul Kumar Garg, Dr. Ashok Dashora
Geetanjali Institute Of Pharmacy,
Udaipur 313001
*jeevanmenaria@gmail.com

22 August 2013

ANTI INFLAMMATORY ACTIVITY OF ZEA MAYS (CORN SILK)

About Author:
Supriyo Karmakar
Department of Pharmacy
Bengal School Of Technology, Hooghly, India
Supriyo.karmakar92@gmail.com

Abstract
Plant materials have been used as medicine for a wide variety of human ailments due to increase cost of treatments, side effects of several allopathic drug and development of resistance to currently used drug for infectious disease. Cornsilk (Zea mays) is an herbal remedy made from stigmas, the yellowish thread-like strands found inside the husks of corn. Cornsilk is used to treat urinary tract infections and kidney stones in adults. Cornsilk also served as a remedy for heart trouble, jaundice, malaria, and obesity.

21 August 2013

CAPSULE FORMATION: FROM CONVENTIONAL TO ADVANCED

ABOUT AUTHORS:
Vivek P. Chavda*, Maunit B. Mehta, Hamir B. Vala, Nirav A. Pandya
Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
Rajkot – 360003, Gujarat (India)
*vivek7chavda@gmail.com

21 August 2013

PHOTOSTABILITY TESTING

ABOUT AUTHOR:
Mr. Vivek P. Chavda, Dr. Moinuddin M. Soniwala
Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
Rajkot – 360003, Gujarat (India)
vivek7chavda@gmail.com

INTRODUCTION^1,2
In recent years, many important initiatives have been undertaken by regulatory authorities and industry associations to promote international harmonization of regulatory requirements. International Conference on the Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) was organized in April 1990 and has as its sole and primary purpose the creation of international standards for the purpose of pharmaceutical research. This process was initiated in order to harmonize the submission requirements for new pharmaceuticals in the three main regions of Europe, the United States, and Japan and to avoid duplication, inefficiencies and delays.

The six cosponsors of ICH were