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  • PharmaTutor
    5 September 2013

    FORMULATION AND EVALUATION OF CETIRIZINE HYDROCLORIDE FAST DISSOLVING ORAL FILMS

    ABOUT AUTHORS:
    *1Charugundla Harini,2 K. Sudheer kumar
    1Kakadiya University, Warangal
    2Bijupatnaik University of Technology & Sciences, Odisha
    charugundlaharini@gmail.com

    ABSTRACT
    The aim of present research was to develop a fast releasing oral polymeric film, with good mechanical properties, instant disintegration and dissolution, producing an acceptable taste when placed on tongue. Solvent casting method was used to prepare oral films. cetirizine hydrochloride an antihistaminic was incorporated to relieve the symptoms of allergic rhinitis. The polymers selected were HPMC 3cps and PVA. Glycerin was the plasticizer used. Eight batches of films with drug were prepared using different combinations of polymer concentration. The resultant films were evaluated for weight variation, content uniformity, folding endurance, thickness, surface pH, tensile strength, % elongation, % moisture absorption, %moisture loss in vitro disintegration and in vitro dissolution. The optimized films have disintegrated within 28-60sec. The percentage release was varying with concentration of polymer. The films made with HPMC3cps 200 mg released 98.5% of drug in 2min, which was the best release amongst all.

  • COMPARISON OF NEW DRUG APPROVAL PROCEDURES AND REGULATORY STRUCTURES IN TURKEY AND CANADA
    5 September 2013
    COMPARISON OF NEW DRUG APPROVAL PROCEDURES AND REGULATORY STRUCTURES IN TURKEY AND CANADA

    About Authors:
    Abhisek Shukla*, Dr. Valluru Ravi
    Pharmaceutical Regulatory Affairs group, Dept. of Pharmaceutics,
    JSS College of Pharmacy, JSS University,
    Sri Shivarathreeshwara Nagar, Mysore-570015, Karnataka, India.
    abhishekjsscp@gmail.com

  • A REVIEW : SELECTION OF DISSOLUTION MEDIA
    3 September 2013
    A REVIEW : SELECTION OF DISSOLUTION MEDIA

    ABOUT AUTHOR:
    Mr. Ripal Mistry
    M.pharm, Indubhai Patel College Of Pharmacy & Research Center,
    Dharmaj
    Rx.ripalmistry@gmail.com

    DEFINATION:

  • NATURAL POLYMERS USED IN FLOATING DRUG DELIVERY SYSTEM
    30 August 2013
    NATURAL POLYMERS USED IN FLOATING DRUG DELIVERY SYSTEM

    ABOUT AUTHOR:
    Jeevan Menaria*, Rahul Kumar Garg, Dr. Ashok Dashora
    Geetanjali Institute Of Pharmacy,
    Udaipur 313001
    *jeevanmenaria@gmail.com

  • ANTI INFLAMMATORY ACTIVITY OF ZEA MAYS (CORN SILK)
    22 August 2013
    ANTI INFLAMMATORY ACTIVITY OF ZEA MAYS (CORN SILK)

    About Author:
    Supriyo Karmakar
    Department of Pharmacy
    Bengal School Of Technology, Hooghly, India
    Supriyo.karmakar92@gmail.com

    Abstract
    Plant materials have been used as medicine for a wide variety of human ailments due to increase cost of treatments, side effects of several allopathic drug and development of resistance to currently used drug for infectious disease. Cornsilk (Zea mays) is an herbal remedy made from stigmas, the yellowish thread-like strands found inside the husks of corn. Cornsilk is used to treat urinary tract infections and kidney stones in adults. Cornsilk also served as a remedy for heart trouble, jaundice, malaria, and obesity.

  • CAPSULE FORMATION: FROM CONVENTIONAL TO ADVANCED
    21 August 2013
    CAPSULE FORMATION: FROM CONVENTIONAL TO ADVANCED

    ABOUT AUTHORS:
    Vivek P. Chavda*, Maunit B. Mehta, Hamir B. Vala, Nirav A. Pandya
    Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
    Rajkot – 360003, Gujarat (India)
    *vivek7chavda@gmail.com

  • PHOTOSTABILITY TESTING
    21 August 2013
    PHOTOSTABILITY TESTING

    ABOUT AUTHOR:
    Mr. Vivek P. Chavda, Dr. Moinuddin M. Soniwala
    Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
    Rajkot – 360003, Gujarat (India)
    vivek7chavda@gmail.com

    INTRODUCTION1,2
    In recent years, many important initiatives have been undertaken by regulatory authorities and industry associations to promote international harmonization of regulatory requirements. International Conference on the Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) was organized in April 1990 and has as its sole and primary purpose the creation of international standards for the purpose of pharmaceutical research. This process was initiated in order to harmonize the submission requirements for new pharmaceuticals in the three main regions of Europe, the United States, and Japan and to avoid duplication, inefficiencies and delays.

    The six cosponsors of ICH were

    1. European Commission,
    2. European Federation of Pharmaceutical Industry Association (EFPIA),
    3. Japanese Ministry of Health (MHW),
    4. Japanese Pharmaceutical Manufacturers Association (JPMA),
    5. Food and Drug Association (FDA), and the Pharmaceutical Research
    6. Manufacturers of America (PhRMA)
  • CURRENT AND FUTURE TREND IN NANOTECHNOLOGY: A REVIEW
    20 August 2013
    CURRENT AND FUTURE TREND IN NANOTECHNOLOGY: A REVIEW

    ABOUT AUTHORS:
    Anjali* , Lakshmi Goswami, Dr. Preeti Kothiyal
    Shri Guru Ram Rai Institute of Technology and Sciences
    Patel nagar, Dehradun
    anjali23mar@gmail.com

    ABSTRACT
    In field of nanotechnology nonmaterial are at the leading edge. Nanotechnology has received a lot of attention with enthusiasm because of its future potential. Their unique size-dependent properties make these materials greater and indispensable in many areas of human activity. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Polymeric nanoparticles have been extensively studied as particulate carriers in the pharmaceutical and medical fields, because they show promise as drug delivery systems as a result of their controlled and sustained release properties, subcellular size, biocompatibility with tissue and cells. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses required. This brief review tries to summarise the most recent developments in the field of applied nanomaterials, nanoparticles, solid lipid nanoparticles, nanocrystals, nanosuspensions, nanoemulsions, in particular their application in biology and medicine, and discusses their commercialisation prospect.

  • TREATMENT OF XENOBIOTICS OF INDUSTRIAL WASTE WATER BY MIXED CULTURED MICROBES
    19 August 2013
    TREATMENT OF XENOBIOTICS OF INDUSTRIAL WASTE WATER BY MIXED CULTURED MICROBES

    About Authors:
    Saptaparna Mukherjee
    Emami Limited, Quality Control
    West Bengal University of Technology
    sapta.muk@gmail.com

  • A REVIEW: FAST DISSOLVING DRUG DELIVERY SYSTEM
    13 August 2013
    A REVIEW: FAST DISSOLVING DRUG DELIVERY SYSTEM

    ABOUT AUTHORS:
    Rahul Ratnakar*1, Lakshmi Goswami2, Dr. Preeti kothiyal
    1Persuing M.Pharma
    2Lecturer/guide
    1,2Shri Guru Ram Rai Institute of Technology & Science,
    P.O. Box - 80, Patel Nagar,
    Dehradun 248001, Uttarakhand, India.
    rhl.ratnakar@gmail.com

    ABSTRACT
    Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance [1]. Mouth dissolving tablets are solid dosage forms containing drugs that disintegrate in the oral cavity within less than one minute the development of mouth dissolving tablets formulation is emerging and gaining popularity because it is easy to administer and leads to better patient compliance [2]. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds’. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab) (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva [3]. MDTs can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients. This is seen to afflict nearly 35% of the general population and associated with a number of conditions, like parkinsonism, mental disability, motion sickness, unconsciousness, unavailability of water etc. To overcome such problems, certain innovative drug delivery systems, like ‘Mouth Dissolving Tablets’ (MDT) have been developed [4].

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