Review Articles

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S. Dhivya*, DR. A. N. Rajalakshmi
Department of Pharmaceutics, Mother Theresa Post Graduate and Research Institute of Health Sciences,  Gorimedu, Puducherry-605006, India.

ABSTRACT:
Design and development of herbal nanoparticles has become a frontier research in the nanoformulation arena. Curcumin is the main bioactive component contained in Curcuma longa, largely employed in traditional medicine. Recently, beneficial properties, useful for prevention and treatment of several disorders, have been discovered for this compound. Although curcumin has shown therapeutic efficacy against many human ailments, one of the major problems with curcumin is its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid systemic elimination. Therefore introduction of nanotechnology provides a solution towards increased bioavailability of curcumin. In this review, the various methods of preparation of curcumin nanoparticles are briefly discussed.

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SUNIL JAIN*, HARVINDER POPLI, GEETA AGGARWAL, MADHU GUPTA
Dept. of Pharmaceutics, School of Pharmaceutical Sciences
Delhi Pharmaceutical Sciences and Research University,
New Delhi -110017

ABSTRACT
It is worldwide accepted that green tea have supernatural property to fight against chronic diseases such as cancer and many more. The presence of polyphenols in green tea is having such property to protect against severe disease and have antioxidant potential. The purpose of this review to explore the beneficial antioxidant potential of green tea with compilation of previously published literature. Green tea is produced from the leaves of the Camellia sinensis plant has provided to be the most popular beverages worldwide. Now people from 160 countries in the world are accustomed to tea drinking although the amount of green tea consumption in worldwide is less than other tea and coffee. Generally, green tea has been found to be superior to black tea in terms of health benefits due to their greater health benefits their demands and popularities are enhanced. The processes used in the manufacture of black tea are known to decrease levels of the monometric catechins to a much greater extent than the less severe conditions applied to other teas. Green tea is accounted for to contain a large number of bioactive fixings which are nearly contributed by polyphenols which assumes a key part of counteractive action and treatment of numerous infections and diseases. The major polyphenols in green tea are catechins, epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). Epigallocatechin gallate is viewed as the most significant active component. This review highlights chapter will highlight the antioxidant activities of green tea that is connected with the high cell reinforcement parts of green tea. This article shows the advantages of green tea for its calming, cancer prevention agent potential and oral human services. Despite the fact that the human clinical information is as yet constrained, this article demonstrates that green tea has its place in both the traditional and elective medicinal groups.

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Sumedha Saxena, Chandan Kumar Singh*, MukeshYadav, Alex Laurel Samson.
Department of Pharmacy, Dr. M.C. Saxena College of pharmacy, Lucknow, (U.P.)
^*chandansingh.skic@gmail.com

ABSTRACT
This review mainly focus on targeted drug delivery to the colon is extremely desirable for local treatment of inflammatory bowel disease such as ulcerative colitis, crohn's disease, amoebiasis, colonic cancer as well as for systemic delivery of protein and peptide drugs. The colon is a site where local delivery allows topical treatment of inflammatory bowel disease and systemic delivery of drug can take place. Treatment of colon can be made effective if the drug can be targeted directly into the colon because drug release and absorption should not be take in abdomen and the small intestine and bioactive agents should not be degraded and to allow drug release into the colon. Drug targeting to the colonic area is not only associated with the treatment of colonic ailment locally but also delivering drugs such as protein and peptide for their systemic effects which are degraded and bioavailability is very depressed due to the instability in the GI Tract.

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VINOTH KUMAR P ¹, *RAJALAKSHMI A.N.¹, STEPHEN P^2
1Department of Pharmaceutics, College Oof Pharmacy, Mother Theresa Postgraduate And Research Institute of Health Sciences, Puducherry-6, India
¹ Department of Pharmaceutics, College of Pharmacy, Mother Theresa Postgraduate And Research Institute of Health Sciences, Puducherry-6, India
² Formulation Research and Development, Sai Mirra Innopharm Pvt Ltd., Chennai, India
*ocusertraji@gmail.com

ABSTRACT:
Orodispersible liquisolid system is the combination of liquisolid technique and orodispersible system. The poor dissolution rate of water insoluble drug is a major drawback for the development of pharmaceutical dosage forms. The oral absorption of drug is most often controlled by dissolution in the gastrointestinal tract. Liquisolid system has been used to enhance dissolution rate of poorly water-soluble drugs. Orodispersible tablets are given in order to provide fast action by disperse in the mouth, without the need of water and make them compliance for paediatric and geriatric patients and to bypass the liver metabolism.

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Kshitij Nuwal, Shailja Jain, Kamal S. Rathore
B.N.I.P.S., UDAIPUR
kshitij.nawal10@gmail.com

ABSTRACT:
The largest, longest study conducted on depression treatments, called the STAR*D trial, found that after people tried four antidepressants over the course of five years, about 70% of them were free of depressive symptoms. That’s a lot of trial and error to end at a place where 30% of patients don’t experience remission at all. The STAR*D trial ended in 2014, and despite a clear hole in the market–and a clear patient need–a golden age of new depression treatments still hasn’t arrived. The anesthetic ketamine could offer hope for people who don't have other depression treatment options. The most recent research on ketamine, as well as a statement from experts on its use published in April 2017, finds the drug works quickly, makes dramatic improvements in mood, and can work on people who haven’t gotten better with other depression treatments.

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Vipul Gandhi^*, Sushil Burle, Satish Kosalge
Hi-Tech College of Pharmacy Chandrapur
Padoli Phata,  Nagpur Highway, Morwa, Chandrapur-442406.
*vipul96gandhi@gmail.com

ABSTRACT
Some of the problems with Un productive relaxing treatments and insufficient repair aptitude in the central nervous system are most troubling problems for few neurological diseases. Providentially, the development of clinically relevant populations of stem cells has provided an opportunity to overcome the failure of endogenous repair systems and substitute new cells into the injured brain. However, there are still several existing difficulties in interpreting into clinical application. In this review, we mainly focus on the stem cell based therapies for Parkinson’s disease and discuss the possible advantages and drawbacks. We hope this review may provide suggestions for viable policies to overcome the current technical and biological issues relatedto the application of stem cells in Parkinson’s disease (Fu et al., 2015).

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D.Visagaperumal*, Justin Ebuka Ezekwem, Hemaprasad Munji, Vineeth Chandy
Department of Pharmaceutical Chemistry,
T. John College of Pharmacy, Bangalore, Karnataka, India
*vishak_dr@yahoo.co.in

ABSTRACT
The review article is focused on studies of Isatin-based Schciff Bases and their biological and pharmacological activities. Isatin-based Schiff base are generally synthesized by condensation of the keto group of Isatin with different aromatic primary amines carrying imine or azomethine (–C=N–) functional group. Isatin Schciff Base possesses numerous biological properties like antitumor, antimicrobial, anti-inflammatory, anticonvulsant, antiviral, anti HIV, antioxidant, CNS depressant activities

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Muthyala Nagavamsidhar*¹, Qadrie ZL.², Suman A.¹
*¹ Department of Pharmacy Practice,
Pratishta Institute of Pharmaceutical Sciences,
Suryapet, Hyderabad, Telangana, India
nagavamsi.muthyala@gmail.com

ABSTRACT:  Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. The WHO has rated migraine amongst the top 20 most disabling life time conditions. Migraine is a pervasive and debilitating, chronic neurological painful disorder, affecting from 15% to 29% of the general population. It is the second most common cause of headache characterized by recurrent episodes of headache and associated symptoms i.e. nausea, sensitivity to light and noise that typically last from 4 to 72 hours which is divided into four phases. Migraine is well explained with three hypothesis i.e., vascular, platelet, central nervous system. It affects people of all groups, sexes, races and social classes around the globe. Migraine can occur due to various trigger factors and can be managed with both pharmacological and non-pharmacological treatment.