Jaipur

About Authors:
Tarun Parashar^1*, Soniya¹, Satyanand Tyagi², Patel Chirag J³, Rishikesh Gupta⁴, Ram Narayan Prajapati^4
1*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248002.
²President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*parashar89tarun@gmail.com, +91-7838447014/08006939831

ABSTRACT:
Heat shock proteins (HSP) are a group of proteins the expression of which is increased when the cells are exposed to elevated temperatures. HSP are present in cells under normal conditions, but are expressed at high levels when exposed to sudden temperature jump or other stress. HSP stabilize proteins and are involved in the folding of denatured proteins. High temperatures and other stresses, such as altered pH and oxygen deprivation, make it more difficult for proteins to form their proper structures and cause some already structures protein to unfold. Left uncorrected, mis-folded proteins form aggregates that may eventually kill the cell. HSB are induced rapidly at highly levels to deal with this problem. HSP have wide clinical applications, they are not only useful as Cancervaccine adjuvant as well as anticancer therapeutics, and also they are useful in agricultural field. The aim of present article is to provide in depth knowledge about clinical indications of these proteins so called as “Heat Shock Proteins”.
An attempt is also made to focus on functions, characteristics, types, qualities, clinical significance as well as brief description of Heatshock proteins.

About Authors:
Satyanand Tyagi*, Patel Chirag J¹, Tarun Parashar², Soniya², Rishikesh Gupta³, Devesh Kaushik⁴
*President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy),
Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers, review articles and short communications. He is member of Editorial Advisory Board for some reputed Pharmacy Journals. He is appointed as an Author for International Pharmaceutical Writers Association (IPWA). (Appointed as an author for the chapters of book on Pharmaceutical Chemistry). His academic work includes 62 Publications (52 Review Articles, 08 Research Articles and 02 short Communications of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 62 publications, 11 are International Publications). His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-302020.
³Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
⁴Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*sntyagi9 @yahoo.com, +91-9871111375/9582025220

ABSTRACT:
Diabetes is usually a lifelong (chronic) disease in which there are high levels of sugar in the blood. Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate, or because the body's cells do not respond properly to insulin, or both. Patients with high blood sugar will typically experience polyuria (frequent urination), they will become increasingly thirsty (polydipsia) and hungry (polyphagia). Cashew nuts have a relatively high fat content, but it's what dieticians consider “good fat.” It's good fat because it has the ideal fat ratio of 1:2:1 for saturated, monosaturated, and polyunsaturated fat.

About Authors:
Manish Jaimini^*, Vishal Joshi
Dept. Of Pharmaceutics, Jaipur college of Pharmacy,
Sitapura, Jaipur (Raj.) 302022
*manishjaimini@gmail.com

ABSTRACT
Novel drug delivery system as a major advance to solving the problems related to the release of the drug at specific site. These systems have several advantages over conventional multi dose therapy. There are various approaches in delivering a therapeutic substance to the target site in a sustained release fashion. One such approach is using microspheres as carriers for drugs. Microencapsulation is used to modify and delay drug release from pharmaceutical dosage forms.  Microspheres efficiently utilized in controlled delivery of many drugs but wastage of drug due to low drug entrapment efficiency is the major drawback of such micro-particulate system. This review provides brief information about floating microspheres, method of preparations, evaluation and application of microspheres for sustained drug delivery.

About Authors:
Satyanand Tyagi^1*, Patel Chirag J¹, Patel Jaimin¹, Chaudhari Bharat¹, Ram Narayan Prajapati^3
1*President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy),
Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers, review articles and short communications. He is member of Editorial Advisory Board for some reputed Pharmacy Journals. He is recently appointed as an Author for International Pharmaceutical Writers Association (IPWA). (Appointed as an author for the chapters of book on Pharmaceutical Chemistry). His academic work includes 62 Publications (52 Review Articles, 08 Research Articles and 02 short Communications of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 62 publications, 11 are International Publications). His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
²Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
³Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*sntyagi9@yahoo.com, +91-9871111375/09582025220

ABSTRACT:
A Genetically Modified (GM) tomato, or transgenic tomato or genetically engineered is a tomato that has had its genes modified, using genetic engineering. The first commercially available genetically modified food was a tomato engineered to have a longer shelf life. Currently there are no genetically modified tomatoes available commercially, but scientists are developing tomatoes with new traits like increased resistance to pests or environmental stresses. Other projects aim to enrich tomatoes with substances that may offer health benefits or be more nutritious.

Synergy Diagnostics pvt Ltd, a Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.

Synergy Diagnostics pvt Ltd, a Leading Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.

About Authors:
Mr. Satyanand Tyagi*, Patel Chirag J¹, Devesh Kaushik²
*President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic work includes 60 Publications (50 Review Articles, 08 Research Articles and 02 Short Communications of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 60 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*sntyagi9@yahoo.com, +91-9871111375/9582025220

ABSTRACT:
A group of Australian researchers at the Garvan Institute in Sydney have conducted a study indicating how Grb10 protein plays a crucial role in increasing muscle mass during development. Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Over expression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.Scientists have discovered a way to build bigger and stronger muscles without having to lift a finger.

About Authors:
Patel Chirag J^1*, Satyanand Tyagi², Patel Jaimin^1
1Maharishi Arvind Institute of Pharmacy, Department of Pharmaceutics, Jaipur, Rajasthan.
²President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India.
*chirag.bangalore@gmail.com, +918000501871

ABSTRACT:
Now a day about 74% of drugs are taken orally and are found not to be as effective as desired either due to bioavailability problems or degradation of drug in acidic pH of stomach. To resolve such problems, transdermal drug delivery system (TDDS) was emerged. Transdermal drug delivery systems are dosage forms involves drug transport to viable epidermal and dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. Transdermal drug delivery systems, also known as ‘‘patches,’’ are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. This review article provides an overview of TDDS, advantages, limitations, various components of TDDS, methods of preparation, types of transdermal patches, factors affecting transdermal permeation, evaluation parameters and new approaches in TDDS.