The Kerala Public Service Commission is a body created by the Constitution of India.

ANSWERS of Previous PharmaQUIZ-2:

1.C   2.C   3.B   4.A   5.C

6.D   7.D   8.E   9.A   10.B

About Authors:
Priya Pathak, Dr.H.H.Siddiqui*, Mr T.Mehmood
Faculty of pharmacy
Integral University,Lucknow

ABSTRACT
The article is a review on all the methods which have been evolved in recent times for curbing the menace caused by arsenic to our environment and humans. Arsenic poisoning is the most spread problem these days in India,as the main reasons of arsenic poisoning include the wastes being dumped by industries which in turn helps in increasing the amount of arsenic in groundwater. Mostly used method for removal of arsenic is oxidation of As(III) to As(V) and its subsequent removal through adsorption and/or precipitation.Generally alumina is used for adsorption purpose.Many methods have also been evolved for managing the increase of arsenic amount through wastes like Cement Solidification, Dolocrete Encapsulation Technology etc.which have been discussed later in the article. Many low cost technologies are also present like Arsenic removal plant fitted directly with hand pump, Co-precipitation-Sedimentation-Filtration under continuous flow system and use of Domestic filters.These techniques are used in case when large amount of water has to be treated as rest other technologies will become quite costly in this case.Although they cannot help in removing arsenic at large level but can be used in our daily life so that we could control arsenic pollution to some extent.

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About Author:
D. J. Kalena^*, C. N. Patel
Department of Quality Assurance,
Shri Sarvajanik Pharmacy College,
Near arvind baug, Mehsana - 384 001, Gujarat, India

ABSTRACT
Combination therapy of Atorvastatin calcium (AT) and Olmesartan medoxomil (OLM) is used for the treatment of coexisting essential hypertension and hyperlipidemia in adult persons. In the present study a simple, precise, rapid, efficient and reproducible reversed?phase high performance liquid chromatography (RP?HPLC) method has been developed for the simultaneous estimation of AT and OLM present in its tablet dosage forms. Chromatographic separations were carried out isocratically at 30°C ± 0.5°C on a Kromasil C18 Column (5 μm, 250mm x 4.60mm) with a mobile phase composed of Methanol: Acetonitrile: Water (pH 3.65) in the ratio of 50:27:23 % v/v at a flow rate of 1.0 ml/min. Detection is carried out using a UV detector at 260 nm. The retention times for AT and OLM were 5.3 ± 0.5 min and 3.4 ± 0.5 min respectively. The linearity range for AT and OLM were found to be 10?60 μg/ml and 20?120μg/ml with correlation coefficient of 0.996 and 0.999 respectively. The %recovery of the proposed method was found in the range of 98.36-100.91 for AT and 99.27-100.99 for OLM. The relative standard deviations for three replicate measurements in three concentrations of standard solution were always less than 2%. The results of the study showed that the proposed RP?HPLC method is simple, rapid, precise and accurate, which may be useful for the routine estimation of AT and OM in bulk drug and in its pharmaceutical dosage form.

October 2011

ANSWERS QUIZ-1:

1.C   2.A   3.C   4.A   5.B

6.A   7.B   8.B   9.D   10.C

Now onwards you will receive daily quizzes that will summrize your pharma knowledge and also help you to prepare for precious entrances like GPAT, NIPER JEE, MAHE and statewise CET. Test your knowledge and test your skills. This quizzies are started to share knowledge with all pharma people.

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IIT Bombay, set up by an Act of Parliament, was established in 1958, at Powai, a northern suburb of Mumbai. Today the Institute is recognised as one of the centres of academic excellence in the country. Over the years, there has been dynamic progress at IIT Bombay in all academic and research activities, and a parallel improvement in facilities and infrastructure, to keep it on par with the best institutions in the world.

BHEL-Bhopal, one of the major units of BHEL- the Country's premier engineering Organisation and a NAVRATNA PSU which provides world class products and services to the core sectors like Power, Transportation, Transmission, Defence and Electronics sectors, invites applications for its well-equipped 300 bedded Kasturba Hospital from Para-Medical Staff of Indian origin for the following posts on purely Fixed Tenure Appointment basis. Preference will be given to the residents of MP. State.

Winning Pharmaceutical organisation with R&D base, employees are key assets and back bone at Molechem Therapeuticals. We believe that work dedication and quality of our team that makes an organization great. They are always on the lookout for self-driven individuals who take ownership of their responsibilities.

United Biotech has been a trend setter of new standards and is among the fastest growing companies in the Indian pharmaceutical Industry. In a span of 12 years it has established an enviable reputation and track record for adopting latest manufacturing technologies, introducing world-class quality of products, ground breaking Research & Development efforts in association with its foreign counterparts and for setting new standards of customer service.

About Authors:
Kapil Sharma¹*, Subhash Gupta ², Yogesh Sharma¹
1 Yaresun Pharmaceuticals Pvt. Ltd.Jaipur - 302006, Rajasthan, India.
2 Oasis test house ltd.jaipur-302006,
Rajasthan, India.

METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF TORSEMIDE IN TABLET DOSAGE FORM BY RP-HPLC AND UV SPECTROPHOTOMETRY AND COMPARISON OF TWO DEVELOPED METHODS BY USING t-TEST

ABSTRACT
One HPLC and one UV spectrophotometric method have been developed for the determination of torsemide (TRS) in tablet dosage form. The first method is based on determinetion of TRS in tablet dosage form by RP- HPLC method.  Chromatgraphy was carried out on a nucleosil C-18,250 x 4.6 mm column using a mixture of phosphate buffer and methanol  (50:50 v/v)  as the mobile phase at a flow rate of 1.3 ml/min.  Run time was 15 min.  Detection was done at 288 nm and retention time of the drug was 7.05 min.  This method produced linear responses in the concentration range 60-140  µg/ml of torsemide. The accuracy of the method was assessed by recovery studies and was found to be 99.90± 0.41 for torsemide.  The second method is based on the estimation of torsemide in tablet dosage form by UV spectrophotometry using 50% v/v methanol in distilled water.  Beer’s law obeyed over the concentration range 2-26 µg/ml at 288 nm with apparent molar absorptivity of 1.26 x 10⁴.  Both developed methods were found to be applicable for routine analysis of drug in tablet dosage form. The result of the analysis were validated statistically.The results were compared obtained from UV spectrophotometry and HPLC.

About Author:
Rajesh Mujoriya
Sardar patel college of technology,
Balaghat, dis. Balaghat,
MP–481001,INDIA

Abstract
Microspheres offer an excellent solution to creating precise pore sizes in ceramics at reasonable prices.  Polyethylene microspheres offer the added benefit of minimal residue after firing, and the availability in wide size ranges from a few micron up to 1000um (1mm).    Highly spherical microspheres have the added benefit of creating strong pores without any stress risers. Biodegradable microspheres are used to control drug release rates thereby decreasing toxic side effects, and eliminating the inconvenience of repeated injections. Microparticulate carrier system can be administered through different routes such as i.v,ocular,i.m,oral,intra arterial.etc.Each routes has it’s own biological significance, limitation & pharmaceutical feasibility.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output. This university has two campuses, 3 institutes, 16 faculties, 140 departments, 4 advanced centers and 4 interdisciplinary schools.

Govt. of Himachal Pradesh took up initiative in early seventies to set up a CSIR lab to make prudential use of the natural resources of the region. After several levels of discussions a formal request was made by then Chief Minister of HP to Vice President, CSIR in 1982 for initiating the matter, and giving final shape to the proposal.

BIT, Mesra is a "Deemed University" under Sec. 3 of the U.G.C. Act 1956.

Aurobindo Pharma has identified international operations, catering to over 100 countries, as a major engine of growth and expanding global network of marketing and manufacturing operations across countries like China, Brazil, Japan, Netherlands, South Africa, Thailand, UK, USA, Russia, Netherlands and many more which will further expand its international reach.

Biocon is a research-driven, global healthcare company with a strong matrix of capabilities along the biopharmaceutical value chain. Focusing on unmet medical needs in cancer, diabetes and inflammatory diseases, it offers novel therapies on a platform of affordable innovation.