"La Renon" is created out of passion to become a global healthcare company by offering World-class quality pharmaceutical products and services for various critical illnesses and diseases.

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology, Government of India.

GPAT-2012 PAPER

{Answers are on the end page of question Paper}

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Naprod’s vision is to become a world class player in oncology through excellence in innovation, discovery of new manufacturing processes / drug delivery mechanisms and consistently high quality of production. We commenced operations in 1994 with the inauguration of our ultra-modern facility for the production of generics and formulations for oncology and other therapeutic applications.

ABOUT AUTHORS:
YASWANTH ALLAMNENI^1*, NAVYA ALLAMNENI², R AMARNATH¹, T RAMASWAMY CHOWDARY¹, V SATYANARAYANA¹, K VENKATESWARA RAO^1
1Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar, Andhra Pradesh – 509228.
²Department of Pharmaceutical Technology, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Guntur,
Andhra Pradesh, India.
*yaswanthallamneni@gmail.com

ABSTRACT
The main aim of this article was to review the development of ODTs, challenges in formulation, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects.Over the past three decades, orally disintegrating tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Orally disintegrating tablets are also called as orodispersible, quick disintegrating, mouth dissolving, fast disintegrating, rapid dissolving tablets, porous tablets, and rapimelts.Orally disintegrating systems have carved a niche amongst the oral drug delivery systems due to the highest component of compliance they enjoy in patients especially the geriatrics and pediatrics. However, of all the above terms, USP approved these dosage forms as ODTs.  These tablets are distinguished from conventional sublingual tablets, lozenges, and buccal tablets which require more than a minute to dissolve in the mouth. According to the recently issued draft guidance for Industry of orally disintegrating tablets, FDA specifically recommends that, in addition to the original definition for an ODT, ODTs be considered solid oral preparations that disintegrate rapidly in the oral cavity, with an in vitro disintegration time of approximately 30 sec or less according to the united states pharmacopoeia (USP) disintegration method or alternative. ODTs release drug in the mouth for absorption through local oromucosal tissues and through pregastric (e.g., oral cavity, pharynx, and oesophagus), gastric (i.e., stomach) and post gastric (e.g. .small and large intestines) segments of the gastrointestinal tract.

Rajasthan Drugs & Pharmaceuticals Ltd (RDPL) is profit making Central Public Sector Enterprise. The The Company was formed as a joint venture between Central Government with 51% equity share holding and Rajasthan State Industrial Development and Investment corporation Ltd (RIICO) with 49% equity share holding. Rajasthan Drugs and Pharmaceuticals ltd.(RDPL) was incorporated on 02.11.1978 with the objective to supply life saving and other essential drugs.

AKUMS DRUGS & PHARMACEUTICALS LTD is one of the most innovative, productive and research based pioneer organization of India having its registered office at Delhi and various plants in Haridwar, Uttrakhand

Krishna Institute of Medical Sciences (KIMS) welcomes you to the hi-tech hub of Hyderabad. Centrally located on Minister Road, KIMS is where personalised medicare meets modern technology.At KIMS the cream of specialists come together to fulfill a wide range of medical requirements.

Established in 1995 with a capital of 50 lakhs, Mankind at present is a leading pharmaceutical company of India. Our Goal is to help the community to lead healthy life through two parallel objectives: formulating, developing & commercializing medicines, and delivering affordable & accessible medication that satisfy urgent medical needs.

Bhat Bio-tech India Private Limited is specialized in the design development, manufacture and marketing of diagnostic products and Biotechnology based products.

Post: Marketing Representative-(Life Sciences)

About Authors:
Marvinkumar I. Patel^*, Ravi R. Patel
Nootan Pharmacy College,
Visnagar,
Gujarat, India
*patel.marvin62@gmail.com

Abstract:
Dendrimer chemistry was first introduced in 1978 by Fritz Vogtle and coworkers. He synthesized the first “cascade molecules”, today known as dendritic molecules. The dendrimer architecture permits control over properties such as shape, size, density, polarity, reactivity and solubility. Dendrimer density functions and starburst limits can be easily modeled mathematically. Dendrimers have stimulated wide interest in the field of chemistry and biology, especially in applications like drug delivery, gene therapy and chemotherapy. A treatment of Cancer mainly focused on the targeting the active drug molecule at the site without affecting the neighbour cells and dendrimers have this property which is useful in diagnosis and treatment purpose which is a new hope in this area of Cancer treatment.

The Guru Jambheshwar University of Science & Technology, Hisar, was established on October 20,1995 by an Act of the Legislature of the State of Haryana with the objectives 'to

The Solapur District was ruled by various dynesties such as Andhrabhratyas, Chalukyas, Rashtrkutas, Yadavas and Bahamanis. 'SOLAPUR' is believed to be derived from two words 'SOLA'meaning sixteen and 'PUR' meaning village. Thepresent city of Solapur was considered tp be spread over sixteen villages viz.

Naprod’s vision is to become a world class player in oncology through excellence in innovation, discovery of new manufacturing processes / drug delivery mechanisms and consistently high quality of production. We commenced operations in 1994 with the inauguration of our ultra-modern facility for the production of generics and formulations for oncology and other therapeutic applications.