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QUALITY OF WATER FOR PHARMACEUTICAL USE: AN OVERVIEW

About Authors:
YASWANTH ALLAMNENI1*, NAVYA ALLAMNENI2, P DAYANANDA CHARY1, G VIJAY KUMAR3, ARUN KUMAR KALEKAR1, PAVAN KUMAR POTTURI1
1Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar,Andhra Pradesh – 509228.
2Department of Pharmaceutical Technology, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Guntur, India.
3Principal, A.K.R.G college of Pharmacy, Nallagerla, West Godavari, Andhra Pradesh.

*yaswanthallamneni@gmail.com

ABSTRACT
Water is widely used as a raw material, ingredient, and solvent in the processing, formulation, and manufacture of pharmaceutical products, active pharmaceutical ingredients (APIs) and intermediates, compendial articles, and analytical reagents. This review discusses, primarily from a microbiological aspect, the review and evaluation of high purity water systems that are used for the manufacture of drug products and drug substances. It also includes a review of the design of the various types of systems and some of the problems that have been associated with these systems. As with other guides, it is not all-inclusive, but provides background and guidance for the review and evaluation of high purity water systems. The main objective of this review was to provide guidance to the industry on the pharmaceutical use of different grades of water in the manufacture of active pharmaceutical ingredients and medicinal products for human and veterinary use. This guidance is not intended to cover situations where, for example, medicinal products are prepared extemporaneously or where preparations are reconstituted or diluted with water prior to use by pharmacist (eg. Oral antibiotic mixtures) or in the case of veterinary products by the user (eg. Sheep dips).

Advertisement for Engagement of Paramedical Staff in ESIC- Total 34 posts | require Pharmacist (Modern Medicine & Ayurveda), Staff Nurse, Dietician, Lab Technician, Physiotherapist and more

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The Zilha Parishad of Sangali invites applications for post of Pharmacist - Govt Job

The zilha Parishad of Sangali, The establishment of the Zilla Parishad could be regarded as the culmination point in the achievement of the goal of Local Self-Government. Prior to that, local autonomy was enjoyed in different degrees at the district, taluka and village levels. The Local Self-Governing units were provided by the District Local Board and the village panchayats.

SKS Group of Institutions - Sanjay College of Pharmacy invites for post of Asst Professor

SKS Group of Institutions (SKSgi) marked its expansion in Mathura with the start of Sanjay College of Pharmacy (SCP). SCP was established in the year 2007 and is located right along the Delhi-Agra NH#2, 125 Km from Delhi, 20Km from Mathura and 12Km from Vrindavan. Approved by AICTE - New Delhi, under Ministry of HRD, the Govt. of India.

Applications are invited at Regional Medical Research Centre as Research / Technical Assistant - 2 Posts

Applications are invited for purely temporary posts at Regional Medical Research Centre (ICMR), Belgaum under ad hoc project entitled "Documentation of genetic and phytochemical variation and assessement of immunomodulatory and anticancer activities of Gymnema sylvestre (Retz) R.BR & S and newly described species Gymnema kollimalayanum Ramach & M.B. Viswan, From Eastern India and Western Ghats"

Walk in interview in Indian Council of Medical Research | Opening as Research Scientists II, Research Associate, Senior Research Fellows - 5 posts

The Indian Council of Medical Research (ICMR), New Delhi, the apex body in India for the formulation, coordination and promotion of biomedical research, is one of the oldest medical research bodies in the world.

RESISTANCE IN ANTIBIOTICS DEVELOPED : MAINLY USED IN PREGNANCY

About Author:
Shambhavi Singh
B.Pharm (IV) School of Pharmaceutical Science,
Jaipur national university, Jaipur(RAJ.)

*shambhavisingh3111@gmail.com

Abstract
Broad-spectrum antibiotics are prescribed in one third patients for urinary tract infection, and use of third-generation cephalosporins has doubled in the past decade.

Bacteria in pregnancy frequently produce the risk of pyelonephritis, preterm labour, and low birth weight infants. Commonly prescribed antibiotics such as ampicillin (pivampicillin), amoxicillin, fluroqunin, trimethoprim, and sulphonamide are currently associated with development of a high degree of resistance towards most common pathogen responsible for causing urinary tract infection, Escherichia coli. During the past few decades new researches have been made against development of resistance in antibiotic and new drugs are synthesised. The presumption that if a specific drug is safe for the both pregnant woman and the foetus depends on how widely the drug has been used. A recent survey among general practitioners and obstetricians in confirmed that the beta-lactam antibiotic pivmecillinam and ciphalosporins are the most commonly used agents in the treatment of bacteriuria in pregnancy However, a surprisingly high number of physicians reported that they prescribe TMP/SMX during the first two trimesters in spite of resistance of E. coli and possible adverse effects on the foetus.

Opening for Medical Representative ( working in Nephro- Onco Segment need to apply only) in Claris Lifesciences

Claris Lifesciences is one of the largest sterile injectables pharmaceutical companies in India with a market presence in 91 countries worldwide. We primarily manufacture and market products across multiple markets, and therapeutic segments. A significant majority of these products are generic drugs that are capable of being directly injected into the human body and are predominantly used in the treatment of critical illnesses.

Job as Executive Manufacturing in Parenteral Drugs (India)

Parenteral Drugs (India) Limited is one of the leading and fastest growing healthcare company, that has constantly followed a path created by its own will, hard work and determination. PDPL is involved in research, production and manufacturing of pharmaceutical products viz. intravenous infusion, tablets, capsules, liquids syrups, injections etc. Established in the year 1983, PDPL has dedicated itself to the manufacturing of the best quality vital life saving drugs at the lowest possible cost.

Sales positions in Cardiac Superspeciality div @ Gennova Biopharmaceuticals

Gennova Biopharmaceuticals Ltd is a 100% owned subsidiary of Emcure Ltd.
Established in 1983, Emcure was born out of the vision to create a healthcare company that would address the vast healthcare needs. Our commitment and drive have propelled our growth from a single manufacturing facility during the genesis, to a range of world class manufacturing facilities spread across API, formulations and Biotechnology.

Multiple vacancies in Pharmexx India | Require Area Bussiness Manager, Product Specialist, PSR, Professional Relation Incharge, Medical Sales Officer, RBM, Bussiness Officer, Sales Supervisor, Arogya Health Educator, Brand Promotor, MR

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Jobs in Top Pharmaceutical, CRO Institutes | Require B.Pharm, M.Pharm, M.Sc, B.Sc, Ph.D, MBBS, MD in month of march 12

                      March 2012

Anti-inflammatory activity of Methanolic extract of Root of Achyranthes aspera on Carragenin induced rat paw edema

About Authors:
Gourab Saha*1, Akshaya Kumar Malana, Dr. Sambhit Parida2
1. Department of Pharmaceutics, College of Pharmaceutical Sciences, Mohuda, Berhampur – 760002, Orissa, India
2 College of Pharmaceutical Sciences, Mohuda, Berhampur – 760002, Orissa, India

*gourab.pharma2012@gmail.com

Abstract
This study investigated the anti-inflammatory potential of the methanolic extract of Achyranthes aspera Linn. (Amaranthaceae) in male albino rats after intramuscular administration. This was done using the carrageenan-induced paw edema method (acute inflammatory model).Methanolic extract of Achyranthes aspera showed significant anti-inflammatory activity similar to diclofenac and indomethacin.

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Multiple Vacancies in Baidyanath | Require CEO, Works Manager, Sales Manager - 5 posts

One of India's most respected Companies, Shree Baidyanath Ayurved Bhawan (p) Ltd. (Kolkata), popularly known as Baidyanath, is the acknowledged leader of Ayurvedic know-how.

Recruitment for the post of Sr Research Fellow for ICMR sanctioned project @ STES’S Smt. Kashibai Navale College of Pharmacy

Recruitment for the post of Senior Research Fellow (SRF) for ICMR sanctioned project in Department of Pharmaceutical Chemistry at STES’s Smt. Kashibai Navale College of Pharmacy, Pune

Dr. L.H. Hiranandani College of Pharmacy invites for post of Principal

Dr. L.H. Hiranandani College of Pharmacy (Linguistic Unaided Minority Educational Institution) C.H.M College Campus, Near Railway Station, Ulhasnagar - 421 003. The post is open to all. However candidates from any other category can apply for the posl. Reservation for women & disabled persons will be as per rules. Candidate having knowledge of Marathi will be preferred.

Opening for engagement as SRF/Clinical Registrar/Physician in NIH - govt job - 15 posts

National Institute of Homoeopathy is a model Institute conducting Under Graduate and Post-Graduate courses and Research on various aspects of Homoeopathy. The Institute is having hospital comprising Out-Patients' Department and 100 bedded In-Patients Department (being expanded to 250 beds) along with Laboratory Medicine and Diagnostic sections.

Formulation and Evaluation of Oral Soft Jelly Containing Metformin Hydrochloride and Glimepiride

About Authors:
D.K Jain*, G.N Darwhekar, Vikas Gupta
College of Pharmacy, IPS Academy
Indore (M.P)-452012, India
*jaindkj57@yahoo.com

Abstract
Convenience of administration and patient compliance are gaining significant importance in the design of dosage forms. Metformin hydrochloride and Glimepiride are orally administered antihyperglycemic agent, used in the management of non-insulin-dependent (type-2) diabetes mellitus. Difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and pediatrics. Unfortunately, a high percentage of patients suffering from type-2 diabetes are elderly people showing dysphagia. Persons suffering from dysphagia may get choked when they consume liquid formulation, thus to alleviate such problem liquid formulation of high viscosity was prepared. Formulation of oral soft jellies  was carried out using combination of hydrophilic polymers guar gum and pectin. 3 different  concentrations of guar gum (0.3 to 0.5% w/v)  and 2 concentration of pectin were used (0.2 to 0.3% w/v)  respectively. The prepared batches were evaluated for appearance, viscosity, pH, drug content, syneresis, in vitro drug release, and taste masking. The batch with 0.5% w/v guar gum and 0.2% pectin not only showed 80% drug release at 60 min, but all the desired organoleptic properties. The taste masking was carried out using non nutritive sugar and flavors. The optimized batch showed substantial stability when subjected to short term stability study (0-8°C and Room temperature). The problem of dose measurement by patients was outweighed as oral medicated gels are to be packed in unit dose container.

Work as Senior Research Scientist - oncology in Piramal Life Sciences

Piramal Life Sciences Limited (PLSL) is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly known as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL. PLSL has state-of-the-art R&D laboratories built over 200,000 square-feet of space in Mumbai, India and over 300 scientists engaged in drug discovery and development.

Opportunity to work as Professor/Associate Professor and Associate Professor in Sharda School of Pharmacy

Sharda School of Pharmacy managed by Shardaben Education Trust,Pethapur,Dist & Ta-Gandhinagar

Post: Professor/Associate Professor and Associate Professor

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