Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

Advertisement for Engagement of Retired Paramedical Staff The Medical Superintendent invites application only from retired staff (State/ Central/ESIC/Quasi Govt./Municipal Body/ Defense) for the following post:-

Post: Pharmacist

About Authors:
Raj Mukherjee^*, Koyel Sen, Dr. Ketousetuo Kuotsu^**
* Department of Pharmaceutical Technology, Jadavpur University.
** Assistant Professor,
Department of Pharmaceutical Technology,
Jadavpur University.
* rajmukhrje@gmail.com

Abstract:
“Paclitaxel” is a potent mitotic inhibitor acting as anti-neoplastic agent, obtained as complex diterpins, termed “Taxanes” from the barks of Taxus breufolia (Pacific Yew). The oral bioavailability of the drug varies around 6-7% and has a strong protein binding capacity altering between 89% - 98%. Most of these drugs have a central role in metastatic ovarian and breast carcinoma, along with advanced head and neck cancer, small cell lung cancer, esophageal adenocarcinoma, hormone refractory prostate cancer, Kaposi’s Sarcoma and also in the prevention of recurrent narrowing of Coronary Stents. Paclitaxel mainly functions by improvising enhanced stabilization of microtubule polymers during cell division and binds specifically to the beta-tubulin subunits, thus antagonizing disassembly of the key cytoskeletal protein, producing abnormal arrays of microtubules throughout the cell cycle.  Due to the poor aqueous solubility there is a need for the development of alternative formulations of paclitaxel with improved solubility and at the same time devoid of major toxic effects. Various approaches employed so far include cosolvents, emulsions, micelles, liposomes, microsphere nanoparticles, cyclodextrins, pastes, and implants. All these formulations have been prepared with specific aims to enhance bio-stability and  reduce the basic toxic effects of Paclitaxel including low blood count, hair loss, peripheral neuropathy, anthralgias , myalgias, nausea, vommiting,  mouth sores and various hypersensitivity reactions . The drug undergoes extensive CYP-mediated hepatic metabolism (majorly CYP2C8 with specific contributions from CYP3A4), and not more than 10% of a unit dose is excreted in the urine intact. We have tried to answer the probable mechanisms of Paclitaxel and how it can be made more bio-available in order to enhance its anti-cancer activities. Our review revealed the active ingredients that are co-administered with paclitaxel did not improve its functions but blocked the pathways that decreased the function of paclitaxel, since P-glycoproteins itself reduces the accumulation of paclitaxel and might use it as a substrate.

ABOUT AUTHORS:
Shujauddin Hashmi^*,P. Neelkant reddy, S. hafiz ali, B. Kalyani, K. Karna, S. S.Biradar, Abdul kareem
Department of pharmacy practice
H.K.E Society’s Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences,
MR medical College Road, Gulbarga -585105

ABSTRACT
Diabetes mellitus is a chronic and potentially disabling disease which is like a sleeping giant that is ready to awaken and literally sink our health care system. The present study “Pharmacoeconomic evaluation of anti-diabetic therapy” was carried out with an objective to assess estimated direct medical cost of diabetes and its complications. A hospital based prospective observational study was conducted using a prevalence based ‘cost of illness’ method focusing on estimated direct health care cost of diabetes and its complications. A total of 108 type 2 DM patients were enrolled into the study out of which 68 (62.96%) were males and 40 (37.04%) patients were females. The results revealed that, the average cost was the highest for the age group 45-60 years. The costs for patients with complications were substantially higher than those without complications and the costs were found to increase progressively with the increase in number of complications. The study concludes that Diabetes with complications resulted about 2.5 times higher cost, therefore the burden of diabetes and its complications was significant for individual and families, keeping in mind the burden of the disease on individuals as well as the society, the health policy makers should emphasize on initiatives to prevent the disease prevalence, care and counseling to diabetes patients should be done continuously to prevent the progression of the disease and its devastating complications.

VES College of Pharmacy will be Centre of excellence in the field of pharmacy education and research by aligning itself with mission and by implementing the laid down Quality Policy. The institute plans to achieve this by mentoring pharmacy professionals so that they overcome challenges in the health care industry with knowledge, skills, courage, confidence, compassion and integrity.

The Anjuman-I-Islam, Mumbai was founded in 1874 by a small group of devout and progressive Muslims lead by none other than Dr. Badruddin Tyabji, Third President of Indian National Congress and the First Indian Chief Justice of Bombay High Court, with a ‘desire to see the Muslim Community advance in education and social standing’.

Randstad is an international HR service provider servicing world class companies across the globe. Ma Foi Management Consultants was founded in 1992 by Mr.K.Pandia Rajan and the company was acquired in 2004 by Vedior. A leader in the HR industry in India, with 20 years rich history,Ma Foi became a part of Randstad in 2008 as part of global acquisition of Vedior by Randstad.

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The University Institute of Pharmaceutical Sciences of the Panjab University is a premier institution of Pharmaceutical Education and Research in the country. The institute has covered a long and glorious journey of 76 years starting from Lahore in 1944 and finally settling to the present campus in Chandigarh at the foothills of Himachal.

Applications are invited for the position of a Project Assistant in DST-sponsored project in Cell Biology

Applications are invited for the position of a Project Assistant for in DBT-sponsored project: "Characterization of role of miRNA in apoptosis with special focus on mitochondrial specific miRNA" with Dr. Rajesh Singh, Assistant Professor,Cell Biology Group, IIAR.

A leading Pharmaceutical Company requires Medical Representative at all the major HQ's in India.

Post: Medical Representative & Area manager

Sanyog Pharmacy, We are one of the leading chain of retailers and wholesalers in pharmaceutical products with the turnover of nearing Rs 84 crore approx. spread in all the zones of New Delhi and Northern India having warehouse of 20000 sq. ft. and corporate office of 5000 sq. ft. at Sanyog Mansion, B-1, Yadav Park, Nangloi Delhi & registered office at 9 & 10, Express Plaza, 2nd Floor, Local Shopping Centre, Derawal Nagar, Delhi. We even have a fleet of our own cargos to deliver with commitment.

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