Piramal Life Sciences Limited (PLSL) is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly known as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL. PLSL has state-of-the-art R&D laboratories built over 200,000 square-feet of space in Mumbai, India and over 300 scientists engaged in drug discovery and development.
Post: Research Scientist
Job Responsibilities:
* Performing the Physicochemical characterization of NCE's
* Screening of salts for NCE compounds in High throughput salt screening platform
* Identification of polymorphs, hydrates, solvates for NCE and generic compounds
* He/She will be responsible for routine analytical testing (HPLC, X-ray powder diffraction, DSC, TGA, IR, particle size distribution, microscopy, etc.)
* Job would required to closely work with the formulation scientist in selection of polymers for solid dispersion approach through high through put platform
Skills:
* In depth knowledge and hands on experience in XRPD, crystal behaviors
* Knowledge thermal analytical techniques, salt screening, polymorph identification
* Determination of relevant polymorphic forms of NCE molecules
* Evaluation of polymorphic transformations
* Identification of thermodynamic most stable form
* Identification of hydrates and solvates
* Evaluation of different crystallization techniques (cooling, seeding, addition of antisolvent, pH shift, and salt formation)
* Variation of solvent systems (solvent quality, solvent class)
* Determination of proper stirring time and speed
* Assessment of changes in substrate concentration
* Process development in terms of crystal design (size, shape)
* Comprehensive analytical testing (HPLC, headspace GC, X-ray powder diffraction, IR, NMR particle size distribution, microscopy, etc.)
Additional Information:
Experience: 2-3 Year
Location: Goregaon, Mumbai
Education: Ph.D in organic or Physical Chemistry
Industry Type: Pharma/ Biotech/Clinical Research
Functional Area: R&D
End Date: 21st May, 2014
In case you wish to apply to this position, please send us your CV
Applications maybe sent to research.recruitment@piramal.com.
The subject line may read 'Application for RS - PR&D'
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