Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support.

About Authors:
^*DINESH BABU GOTTIPATI¹, SREE DEVI ANANDHAM¹, NANNAPANENI VENKATA BALAKRISHNA RAO².
¹ Department of pharmaceutics, M.E.S.college of pharmacy, Aradeshally gate, Bangalore -562110,India.
² Research and Development Department, Natco Pharma Limited, Kothur.
*babu.dinesh89@live.in

ABSTRACT:
The aim of this study was to evaluate the effect of increasing nifedipine on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine were prepared by wet granulation technique using Crospovidone and croscarmellose sodium (CCS) as super disintegrants as super disintegrants, Flavor and sweetener impart the taste to the formulation. The porous granules were compressed in to tablets by 8mm punch rotary tablet machine. All the formulations were evaluated for weight variation, hardness, friability, content uniformity, wetting time, and disintegration time and dissolution rate. Among the formulations, F9 one containing to be the best acceptable in terms of palatability, fast dissolving tablet having adequate strength. The disintegration time was found to be 56 ± 0.4 seconds, hardness of 4.6 ± g /cm², wetting time of 31sec   and drug release of 99.85 % in 9 mins. All the formulations showed low weight variation. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

Olefia Biopharma Limited, We would like to introduce ourselves as one of the most rapidly emerging FMCG Company in various fields of Pharmaceutical, Cosmetics, Ayurvedics / herbals and biotech.
Olefia Biopharma Limited is utilising MHRA and WHO-GMP Approved manufacturing unit to manufacture various Tablets, Capsule, Syrups, Suspensions and other formulations for its various division viz. Pharmaceutical and Cosmetic i.e. FMCG and exporting to various countries across the Globe.

Applications on plain papers are Invited for the following posts to be filled In the Integrated Campus having the faculties of Engineering, Pharmacy (PCI approved) and Management, AICTE approved, affiliated to Pune University.

Post: Professor, Associate Professor, Assistant Professor

Western Drugs Pvt. Ltd. is working towards excellence since inception in 1989. The Company started production of two bulk drugs viz. Niacin (Nicotinic Acid) and Niacinamide (Nicotinamide) and is committed for total customer satisfaction by providing Quality Product to our customers dealing in Food and Pharmaceutical Industries.
They are certified for their Quality Management System: ISO 9001 : 2000 and honoured with WHO-GMP Certificate.

Polypharm Private Limited, incorporated in 1961, is today a leading manufacturer and supplier of Pharmacopoeial Chemicals, Disinfectant and Germicide Formulations, Acids, Solvents and Laboratory Reagents. It commenced operations in Thane, before moving to its current factory location at MIDC (Maharashtra Industrial Development Corporation) Kalyan, Saravali.