Applications are invited for the position of SRF in ICMR sponsored project: "The study of mitochondrial dynamics during S aureus infection in human epithelial cells" with Dr. Rajesh Singh, Assistant Professor, Cell Biology Group, IIAR.

Post: SRF (One post)

CSIR- OSDD with Vigyan Prasar is conducting a YouTube based short video competition on "The Need of New Drugs for Tuberculosis". All individuals, including students above 18 years of age, educational institutions and organizations are invited to participate in the contest, and win attractive prizes !!!

About Authors:
Amardeep Sharma
Rathi Orthopaedic & research centre,
Ahmedabad, India
amardeep.sharma54@gmail.com
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ABSTRACT:-
The knowledge of breast cancer development and progression has grown in recent years and relatively development of novel therapeutic strategies, but for cancer mortalities in women breast cancer stands at 2^nd position as cause.
In U.S. Approximately 39970 women & 450 men in the U.S. will be diagnosed from the disease in 2011.^[1] Breast cancer is a hormone dependent disease.^[3] Breast cancer occurs when breast epithelial cells grows in abnormal way. HER2/neu, ER, PR, BRCA1, BRCA2 are the well known influencing factors responsible for breast cancer initiation. The major issues that limit the currently available breast cancer treatment are high cost, poor availability and resistance to chemotherapeutic agents. To overcome this problem researchers are working on several novel approaches i.e. “Novel drug targets & Novel target therapies”.
Since from past few years, mammogram is playing a huge role for decreasing incidence rate in developed countries. Breast cancer is adversely affecting the “quality of life” of patients and its impact has been increasing on the Social capital, population structure and economic growth. Need for novel anti breast cancer agent and novel early diagnosis technique is necessary to combat one of the most serious crises facing Human development.

About Authors:
Aman sharma*, Dr. Sunil sharma
Department of Pharmaceutical Sciences,
Guru Jambeshwar University of Science and Technology,
Hisar-125001, Haryana(INDIA)
*amansharma67@rediffmail.com

ABSTRACT
The aqueous extract of the Adansonia digitata (Linn.) leaf was tested for hepatoprotective activity against chemical toxicity with CCl₄ in rats. The aqueous extract exhibited significant hepatoprotective activity and consumption of Adansonia digitata leaf may play an important part in human resistance to liver damage in areas in which the plant is consumed . The mechanism of liver protection is unknown, but could possibly result from triterpenoids, b-sitosterol, b-amyrin palmitate, or/and a-amyrin, and ursolic acid in the leaf.Adansonia digitata leaves are superior in nutritional quality to fruit pulp, and contain significant levels of vitamin A. The leaves are a staple for many populations in Africa, and are eaten fresh or dried. Several plant parts have interesting anti-oxidant and anti-inflammatory properties, and baobab has been used extensively since ancient times in traditional medicine.

The vision of NMIMS University is to define the 21st century technological and management research. Hence the goal for NMIMS University is to encourage excellence in research and publication activities. Research is a precursor to discovery and innovation. The University systems survive on the strength of research i.e. knowledge creation and dissemination system. Realities of the modern world demand interdisciplinary research or research that cuts across the traditional boundaries of discipline.

From a single campus at Clayton with fewer than 400 students, Monash has grown into a network of campuses, education centres and partnerships spanning the globe. With approximately 60,000 students (and 270,000 alumni) from over 170 countries, we are today Australia’s largest university.

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

The vision of NMIMS University is to define the 21st century technological and management research. Hence the goal for NMIMS University is to encourage excellence in research and publication activities. Research is a precursor to discovery and innovation. The University systems survive on the strength of research i.e. knowledge creation and dissemination system. Realities of the modern world demand interdisciplinary research or research that cuts across the traditional boundaries of discipline.

What do you envision for your future? At GE Healthcare, we strive to see life more clearly. Our "healthymagination" vision for the future invites the world to join us on our journey as we continuously develop innovations focused on reducing healthcare costs, increasing access and improving quality and efficiency around the world.

About Authors:
Mr. Satyanand Tyagi*, Patel Chirag J¹, Asheesh Singh²
*President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 52 Publications (44 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 52 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
*sntyagi9 @yahoo.com, +91-9871111375 / 9582025220

ABSTRACT:
Prior studies have suggested that depressed people with evidence of high inflammation are less likely to respond to traditional treatments for the disorder, including anti-depressant medications and psychotherapy. This study was designed to see whether blocking inflammation would be a useful treatment for either a wide range of people with difficult-to-treat depression or only those with high levels of inflammation. The study employed infliximab, one of the new biologic drugs used to treat autoimmune and inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. A biologic drug copies the effects of substances naturally made by the body's immune system. In this case, the drug was an antibody that blocks tumour necrosis factor (TNF), a key molecule in inflammation that has been shown to be elevated in some depressed individuals. Study participants all had major depression and were moderately resistant to conventional antidepressant treatment. Each participant was assigned either to infliximab or to a non-active placebo treatment. When investigators looked at the results for the group as a whole, no significant differences were found in the improvement of depression symptoms between the drug and placebo groups. However, when the subjects with high inflammation were examined separately, they exhibited a much better response to infliximab than to placebo.

About Authors:
Hitesh Chopra*
A.S.B.A.S.J.S.M. College Of Pharmacy Bela Ropar.
chopraontheride@gmail.com

Abstract
The first and the second generation type of dosage forms had been found to have lower efficacy of drug reaching to the targeted tissue this lead to need for third generation drug delivery system which contains the liposomes, microspheres, microcapsules, nanodiamonds etc. with these type of drug delivery system it had been found to have better patient compliance and reduced side effects. The present paper  deals with the same as there is first formation of Metformin double emulsion and then precipitation of the drug from the polymeric solution. In this study challenge was to encapsulate Metformin with high entrapment efficiency by w/o/o double emulsion solvent diffusion technique using non-aqueous processing media. The primary requirement of this method to obtain microsphere is that selected solvent for polymer must be immiscible with non aqueous processing media, so to fulfill the requirement.

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India.

National Institute of Malaria Research (NIMR) was established in 1977 as 'Malaria Research Centre', which was renamed as 'National Institute of Malaria Research' in November 2005. NIMR is one of the institutes of the Indian Council of Medical Research (an autonomous body under Department of Health Research, Ministry of Health & Family Welfare, Govt. of India).

About Authors:
Sahil Jasuja¹*, Mahesh Kumar Kataria¹
1 Department of Quality Assurance,
Seth G.L. Bihani S.D. College of Technical education (Institute of Pharmaceutical Sciences & Drug Research),
Sri Ganganagar, (Raj.), India.
*sahiljasuja@rediffmail.com

ABSTRACT
Regulatory involvement and environmental concerns are causing pharmacists to take a closer look at how their organizations are managing pharmaceutical waste. Each organization should evaluate its current waste management practices in comparison with state regulatory guidelines. Organizations must then develop a comprehensive plan for full compliance through segregation of waste into the appropriate waste streams. The discovery of a variety of pharmaceuticals in surface, ground, and drinking waters around the country is raising concerns about the potentially adverse environmental consequences of these contaminants. Pharmaceutical waste is not one single waste stream, but many distinct waste streams that reflect the complexity and diversity of the chemicals that comprise pharmaceuticals. Pharmaceutical waste is potentially generated through a wide variety of activities in a health care facility, including but not limited to intravenous (IV) preparation, general compounding, spills/breakage, partially used vials, syringes, and IVs, discontinued, unused preparations, unused unit dose repacks, patients’ personal medications and outdated pharmaceuticals. The consistent increase in the use of potent pharmaceuticals, driven by both drug development and our aging population, is creating a corresponding increase in the amount of pharmaceutical waste generated.

About Authors:
Kapil Sharma*, Priyanka sharma
*Yaresun Pharmaceutical Pvt Ltd, Jaipur, India
*pharma_kapil@rediffmail.com

INTRODUCTION
Gas chromatography is a widely used technique for the separation of gaseous and volatile sub which are difficult to separate.The primary limit of s technique is that sample must be capable of being volatilized without undergoing decomposition because of this this technique is replaced by H.P.L.C.It is similar to column chromatography except that the gas is used as the mobile phase instead of the liquid.Here gas as a mobile phase or moving phase is passed through a column a column containing liquid adsorbent coated on inert solid support ,thus the adsorption or partition is possible.Gas solid chromatography(G.S.C) based upon the selective adsorption on solid,so the component of  mixture distributes them selves between the gas phase and adsorbent and the separation is due to adsorptive properties.where as Gas liquid chromatography (G.L.C) is based upon partition between Gas and immobile liquid coated on solid,.so the component of  mixture distributes them selves between the gas phase and liquid adsorbent coated on solid and the separation is due to partition properties¹.

Indian Institute of Chemical Technology, Hyderabad is a premier R&D Institute in India. The Institute had its origin as the Central Laboratories for Scientific & Industrial Research (CLSIR), established in 1944 by the then Government of Hyderabad State. After integration of Hyderabad State with the Indian Union, the laboratory expanded with its growing activities. The main building was formally opened by Pandit Jawaharlal Nehru, the then Prime Minister of India on January 2, 1954.

Centre for Cellular and Molecular Biology, Hyderabad, invites applications from candidates who are bonafide Indian citizens, to pursue research in modern biology leading to a Ph.D. Degree. The projects offered for Ph.D. would be in the broad areas of Cell Biology, Molecular Biology, Genetics, Genomics, Developmental Biology, Nanobiology, Plant Molecular Biology, Protein Structure & Function, Biology of Macromolecules, Biology of Infection, Epigenetics, Chromatin Biology and Bioinformatics.

About Authors:
Dhiren Shah
m.pharmacy
Seth G.L.Bihani S.D.College of Pharmacy, R.U.H.S.
Sri Ganganagar, Rajasthan, INDIA
dhiren.pharmacist@gmail.com

Abstract
A method has been developed for immobilisation of antisera on fresh plastic tubes through an immunochemical bridge. This type of immobilisation has been shown to be more consistent than direct adsorption on plastic. Such immunochemically coated antisera on plastic tube has been used in the development of a noncentrifugation radioimmunoassay. This assay system has been found to be technically as sound as the conventional method.

About Authors:
Mr. Satyanand Tyagi*, Raghvendra¹, Amlan Mishra², Patel Chirag J³, Asheesh Singh⁴
*President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 51 Publications (43 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 51 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders as well as epilepsy.
¹Department of Pharmaceutics, Aligarh College of Pharmacy, Aligarh, U.P, India-202001.
²Department of Pharmacology, Smt. Vidyawati College of Pharmacy, Jhansi, U.P, India-284128.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
*sntyagi9@yahoo.com, +91-9871111375 / 9582025220

ABSTRACT:
The umbilical blood cord being rich in stem cells needs to be preserved by means of a new technique called cryopreservation. The Process whereby whole tissues or cells are preserved by cooling at very low temperatures is known as Cryopreservation. Stem cell cryopreservation is a relatively new phenomenon; it is one way of ensuring the longevity of child’s health. This is done by banking the baby’s umbilical cord blood affluent with stem cells. Stem cells are important as they can grow into tissues, even organs like the heart or liver. What is more, they have the awesome potential to revamp damaged tissues.

Till date, over seventy diseases have been successfully treated with the help of stem cell stored in the cord blood. Research on stem cells has, by no means, abated. Scientists realizing their potential and worth are carrying out intensive research on their uses as well as ways preservation. Before preserving stem cells, a biological test is carried out to eschew the possibility of deadly diseases like various types of Hepatitis or HIV. That done, the cord blood cells are now stored by means of the technique under discussion- Cryopreservation. This technique involves adding a cryopreservant that lets the blood freeze gradually. The blood is frozen to sub-zero degree temperatures so that biochemical reactions or any other dangerous biological that could cause cell death may be arrested. Typically, the cells are stored at temperatures as low as -196, – 156, or – 120 degrees centigrade. Freezing stem cells through cryopreservation at such low temperatures is supposed to ensure their longevity. Let it be known, however, that scientists are still divided over the optimum temperatures as well as the efficacy of the cryopreservation technique itself. The aim of present article is to provide in depth knowledge about this technique of preserving stem cells of child i.e. the technique so called “Cryopreservation”. An attempt is also made to focus how this technique ensures the longevity of child’s health.