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A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION OF PRAVASTATIN IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS

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ABOUT AUTHORS
Grishma Trivedi*, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat
*trivedigrishma18@gmail.com

ABSTRACT
Pravastatin is an inhibitor of HMG-CoA reductase inhibitor which is used as a hypolipidemic agent to reduce cholesterol level. Chemically, 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl disodium phosphate. Pravastatin is a drug of choice for the cardiovascular disease. It reduces the coronary and cerebrovascular morbidity and mortality in middle aged individual. Elevated plasma concentration of C-reactive protein are associated with protein increased cardiovascular disease, long term therapy with pravastatin an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter. This review consist of various analytical methods for the determination of pravastatin in various marketed pharmaceutical formulation of biological fluid. Analytical methods consist of various chromatographic methods, spectrophotometer methods and electrical methods reported for determination of pravastatin.

Walk in interview for B.Pharm, B.Sc, M.Pharm, M.Sc as Medical Coding Executive (50 Opening) in Gebbs Healthcare

GeBBS is a leading provider of healthcare Business Process Outsourcing services to Healthcare Providers (Medical Billing companies, Hospitals, Faculty Practices, ASC’s, LTC’s, etc.) and Pharmacies. We help our clients succeed by leveraging on our domain expertise and technology platforms along with our cost effective approach to global outsourcing.

Post: Medical Coding Executive

Synapse Clinical Research Foundation open for Student Counselor - B.Pharm/BSc/MSc/MBA

Synapse Clinical Research Foundation (SCRF) is a not for profit organization founded to provide patients & their family members, medical & allied healthcare professionals and general public easy access to information on clinical trials currently running in India for different medical diseases.

Post: Student Counselor

Invitation for the post of Ex. Clinical Manager in Novartis

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Post: Ex. Clinical Manager

Walk in interview for M.Pharm as Junior Research Fellow in Kurukshetra University

The Kurukshetra University was established in 1956 as a unitary residential University and its foundation stone was laid by late Dr. Rajendra Prasad, the first President of India. Located in the holy city of Kurukshetra, land of the historical battle of 'Mahabharata' and the great message of Bhagwad Gita, its campus is situated on the western bank of Brahm Sarover (the holy tank) and extends over an area of over 400 acres. Starting with only the Department of Sanskrit, it has grown into a multi-faculty University as one of the premier centres for advanced study and research in the region.

Applications are hereby invited on plain paper from the eligible candidates for one temporary post of Junior Research Fellow (JRF) to work full time under the DST SERB sponsored research project entitled “Design, synthesis, characterization and biological evaluation of anticancer and antiinfective activities of thiazole-based heterocycles”. The details of post are as under:

Post: Junior Research Fellow

Walk in interview for Pharmacist in GSACS - Civil Hospital

Gujarat state is one of the highly industrially developed states in the country. Being an industrialized state, migration of laborers from various parts of India is very high. Mobility and migration of people make them more vulnerable, as a result of separation from spouse and release of social sanctions, leading to high-risk sexual practices and consequently they may contract HIV, which in turn is carried to their spouses and to their children. On the one hand, with an increase in urbanization most of the societies are in transition and the young population is under less social restraint. On the other hand, lower literacy level of rural women, especially in the state and local customs & traditions make women more vulnerable to the infection. Large numbers of women suffer from reproductive tract infections (RTIs), which are mainly due to poor sexual hygiene especially during menstruation and sexually transmitted infections from their spouses.

Post: Pharmacist

B.Pharm/M.Sc candidates invited for JRF posts in DST (SERB) Sponsored Research Project in University of Hyderabad

The University of Hyderabad (UoH), one of the major institutions of higher education in India is largely devoted to postgraduate studies and is widely known for its excellence in research and for its distinguished faculty. Founded in 1974 with Prof. Gurbaksh Singh as its first Vice Chancellor, UoH - also known as Hyderabad Central University or HCU- has emerged as a leading centre of teaching and research. The large campus located near Gachibowli, which is the IT hub of Hyderabad, has immense bio-diversity and is home to over 75 varieties of bird, not to speak of the lakes and rock formations which give the campus a natural beauty.

Post: Junior Research Fellow

Job in BabyJoy IVF Centre for the post of IVF Fertility Specialist

We understand, there cannot be a stronger human emotion than the desire 'to have Your Little One!' "Baby Joy" is our endeavour to be part of your journey towards parenthood. Baby Joy, through its state of the art IVF centre, intends to provide you end to end fertility solutions with warmth & compassion. Baby Joy is one of the largest IVF centres in India with the primary mission to provide Advanced Yet Affordable IVF treatment. It is our vision to set benchmarks in the field of IVF, globally, through cutting edge technology, most advanced treatment protocols, & a highly acclaimed team of doctors, embryologists & support staff.
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Job as Admin Executive in Babyjoy IVF Centre

We understand, there cannot be a stronger human emotion than the desire 'to have Your Little One!' "Baby Joy" is our endeavour to be part of your journey towards parenthood. Baby Joy, through its state of the art IVF centre, intends to provide you end to end fertility solutions with warmth & compassion. Baby Joy is one of the largest IVF centres in India with the primary mission to provide Advanced Yet Affordable IVF treatment. It is our vision to set benchmarks in the field of IVF, globally, through cutting edge technology, most advanced treatment protocols, & a highly acclaimed team of doctors, embryologists & support staff.

Post: Admin Executive

Requires Staff Nurses/Pharmacist (8 Posts) in District De-Addiction and Rehabilitation Society, Pathankot

The advertisement is being issued in accordance with letters nos. 9/64/14-3H6/2300 dt. 16.7.2014, 9/64/2014-3H6/961 dt. 25.7.2014, 9/64/2014-3H6(5H4)'290500'1 dt.19.8.2014 and 9/64/2014-5H4/1251 dt.9.9.2014 of the Department of Health and Family Welfare.Govt, of Punjab.
District De-Addiction and Rehabilitation Society, Pathankot invites application for the following posts on contractual basis for Drug De-Addiction Centres at Pathankot & Narot Jaimal Singh for an initial period of one year.

Post: Staff Nurses/Pharmacist

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Work as Pharmacist in Krishna Medicals

A unique walk-in Retail Pharmacy with seating facility, which has sophisticated facilities like air-conditioned shop floor, computerized work environment and internet connection, which facilitates quick service, maintains the entire medical record of patients for future references and provides a peep into the latest advancement in the medical field.

Post: Pharmacist

Career opportunity for Medical Representative in Soranus Lifesciences, Saurashtra

Soranus Lifesciences is an innovative leading, vertically integrated pharmaceutical formulation company that discovers, develops, manufactures and markets a broad range of healthcare products. Headquartered in the city of Ahmedabad in India, The Company has dedicated research and development department well equipped with the latest equipments and supported by a large pool, of scientists who continuously work towards new pharma products. Soranus Lifesciences Reminisces the Soranus of 1st and 2nd century.

Post: Medical Representative- 1

Opportunity in Govind Ballabh Pant University of Agriculture and Technology for the post of Senior Research Fellow

Applications are invited for Senior Research Fellow from the candidate of the OBC category in a project entitled, “Monitoring of Drug Residues and Environmental Pollutants.” Under out reach programme on Livestock Related Environmental Pollutants, Contamina nts & Toxicants Financed by ICAR. The fellowship is purely temporary and may continue till the duration of the research project. If the candidate from reserve category will not be available, the post will be filled up from General Category.

Post: Senior Research Fellow

Vacancy as Research Assistant for API R&D in A leading US MNC Pharmaceutical- Perrigo

A leading US MNC Pharmaceutical- Perrigo

Post: Research Assistant for API R&D

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No.of post: 2

Vacancy as Associate Scientist/Sr. Research Executive in L'OREAL

For more than a century, we have devoted our energy and our competencies solely to one business: beauty. We have chosen to offer our expertise in the service of women and men worldwide, meeting the infinite diversity of their beauty desires. We are committed to fulfilling this mission ethically and responsibly.

Post: Associate Scientist/Sr. Research Executive

A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION BROMHEXINE HYDROCHLORIDE IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

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ABOUT AUTHORS:
Meera V. Lad1*, Vineet Jain2, Hasumati Raj1
1Department of Quality Assurance,
2Department of Pharmacognosy,
Shree Dhanvantary Pharmacy College, Kim, Gujarat
meeralad235@gmail.com

ABSTRACT:
Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical  and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ionselectiveelectrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.

Pharmacist- Allopathy recruitment (6 Openings) in ONGC | Walk in

Contract basis Pharmacist recruitment in Oil and Natural Gas Corporation Ltd (ONGC)

Post: Pharmacist - Allopathy (General Duty) (LOCALS ONLY)

Faculty position in Shroff S.R. Rotary Institute of Chemical Technology

S R I C T is about finding solutions to social exclusion and disintegration and will look to work with private, public and third sector partners in stimulating cohesion, entrepreneurship, economic development and involvement in neighborhood renewal and regeneration within community of chemical industries at Ankleshwar. The basic academic philosophy of the Shroff S.R. Rotary Institute of Chemical Technology is to focus on Chemical Technology (covering Chemical Engineering and other Chemical Technology Courses) as the Gujarat’s industrial strength lies in these areas besides Chemical Engineering. The other guiding philosophy is to create R & D infrastructure in these areas (including trained manpower) to meet the industrial needs of Gujarat.

Post: Associate Professor, Assistant Professor

Career opportunity for Regional Sales Manager in Origo Pharmaceuticals

Origo Pharmaceuticals Pvt Ltd is a leading company offering a unique range of cosmeceutical products in the Skin Whitening , Anti-ageing and Hair-care segment to its customers across India and the Middle-East. Our objective is to provide superior quality, innovative products that meet the doctor’s and patient’s needs.

Post: Regional Sales Manager- 2

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