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  • PharmaTutor
    29 September 2014

    A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM BY ETHOSOMES

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    ABOUT AUTHORS:
    V. Sujatha*, T. Vishnuvaravidyadhar, M.Parvathi, Suryaprakash Reddy
    *Department of Pharmaceutics,
    Raghavendra Institute of Pharmaceutical Education & Research,
    RIPERK R Palli Cross, Near S.K University, Anantapuramu District, Andhra Pradesh, India
    valmiki.sujatha@gmail.com

    ABSTRACT
    Transdermal drug delivery system is one type of more convenient drug delivery system. Skin acts a barrier for transdermal through drug delivery system. Drug across through stratum corneum by low diffusion process. Drug formulation with elastic vesicle or skin enhances vesicles. Etho sources are the ethanolic phospholipids vesicles and which are having higher rate of penetration through the skin. The purpose of writing this Review on ethosome drug focus on the Ethosomes including their mechanism of penetration. Transdermal drug delivery system was came into existence by more than 30 years ago. Ethosomes are the ethanolic phospholipid vesicles. These are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. Ethosomes enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency etc.

  • A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLE
    26 September 2014
    A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLE

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    ABOUT AUTHORS:
    Monika A. Rana*, Hasumati A. Raj
    Department of Quality Assurance
    Shree Dhanvantary College of Pharmacy,
    Kim, Gujarat, India
    monika92rana@gmail.com

    ABSTRACT
    Levosulpiride is an atypical antipsychotic agent. Levosulpiride is the levo enantiomer of sulpiride. It is a substitute benzamide which is meant to be used for several indications: depression, psychosis, somatoform disorders, emesis anddyspepsia. It blocks the presynaptic dopaminergic D2 receptor. Chemically it is N-[[(2S)-1-Ethylpyrrolidin-2-yl] methyl]-2-methoxy-5 sulfamoylbenzamide. several method such as HPLC in human plasma, area under curve, stability by RP-HPLC is done. The parent drug is given in a dose of 400-1800 mg orally. According to literature survey study of impurity profiling of LIVOSULPIRIDE in presence of intermediate has not been reported.

  • A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION OF PRAVASTATIN IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS
    22 September 2014
    A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION OF PRAVASTATIN IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS

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    ABOUT AUTHORS
    Grishma Trivedi*, Hasumati Raj
    Shree Dhanvantary Pharmacy College,
    Kim, Gujarat
    *trivedigrishma18@gmail.com

    ABSTRACT
    Pravastatin is an inhibitor of HMG-CoA reductase inhibitor which is used as a hypolipidemic agent to reduce cholesterol level. Chemically, 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl disodium phosphate. Pravastatin is a drug of choice for the cardiovascular disease. It reduces the coronary and cerebrovascular morbidity and mortality in middle aged individual. Elevated plasma concentration of C-reactive protein are associated with protein increased cardiovascular disease, long term therapy with pravastatin an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter. This review consist of various analytical methods for the determination of pravastatin in various marketed pharmaceutical formulation of biological fluid. Analytical methods consist of various chromatographic methods, spectrophotometer methods and electrical methods reported for determination of pravastatin.

  • A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION BROMHEXINE HYDROCHLORIDE IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES
    19 September 2014
    A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION BROMHEXINE HYDROCHLORIDE IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

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    ABOUT AUTHORS:
    Meera V. Lad1*, Vineet Jain2, Hasumati Raj1
    1Department of Quality Assurance,
    2Department of Pharmacognosy,
    Shree Dhanvantary Pharmacy College, Kim, Gujarat
    meeralad235@gmail.com

    ABSTRACT:
    Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical  and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ionselectiveelectrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.

  • A REVIEW: ANALYTICAL METHODS FOR DETERMINATION OF CILNIDIPINE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS
    18 September 2014
    A REVIEW: ANALYTICAL METHODS FOR DETERMINATION OF CILNIDIPINE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS

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    ABOUT AUTHORS:
    Farhana V. Buchiya*, Vineet Jain, Hasumati Raj
    Shree Dhanvantary Pharmacy College,
    Kim, Surat, Gujarat
    buchiyafarhana22@gmail.com

    ABSTRACT:
    Cilnidipine is act as a  dual blocker by blocking L- type of calcium channel  present in vascular smooth muscles and  N- type of calcium channel  present in sympathetic nerve  terminal that supply  blood  vessels. Cilnidipine used in treatment of mostly in hypertension and various cardiovascular diseases except in Angina. Cilnidipine used alone or in combination. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of cilnidipine in various pharmaceutical dosage forms and biological matrix were reported.

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  • A REVIEW ON SINGLE USE DISPOSABLE TECHNOLOGY FOR RECOMBINANT PROTEIN MANUFACTURING
    5 September 2014
    A REVIEW ON SINGLE USE DISPOSABLE TECHNOLOGY FOR RECOMBINANT PROTEIN MANUFACTURING

    ABOUT AUTHOR
    Madhusudan P Dabhole
    Group Manager – BioProcess,
    Richcore Life Sciences Ltd, Bangalore, Karnataka, India
    madhav888@rediffmail.com

    ABSTRACT
    The manufacturing of recombinant products by fermentation and purification in stainless steel vessels has seen the transition from small scale to large scale and further to single use disposable technology. The requirement to develop and modulate the process has arisen from the cost and manufacturers need to move the facility on mobile platforms. The review describes the strategies and considerations for Single Use Disposable Technology. Recombinant proteins are widely used for treatment of various diseases and disorders. Single Use Disposable Technology makes it promising to produce and formulate these proteins from bench scale to commercial level in a shorter span of time so that it can reach the physician and patients.

  • ANTACIDS: HEART BURN OTC DRUGS
    28 August 2014
    ANTACIDS: HEART BURN OTC DRUGS

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  • A REVIEW: DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS
    19 August 2014
    A REVIEW: DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS

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    ABOUT AUTHORS:
    Asif I Bhim*, Vineet Jain, Hasumati Raj
    Shree Dhanvantary Pharmacy College,
    Kim, Gujarat, India
    bhimiqbal23@gmail.com

    ABSTRACT:
    Itopride Hydrochloride is a novel, synthesized, gastro prokinetic drug, which stimulates gastrointestinal motor activity through the synergistic effects of dopamine D2-receptor blockade and acetylcholine esterase inhibitors. Chemically, it is N-[[4-[2-(Dimethyl amino) ethoxy] phenyl] methyl]-3, 4-dimethoxy benzamide hydrochloride. Benzamide structure, amide and ether linkages in the drug molecule make it susceptible to degradation. Thus a prokinetic drug like Itopride Hydrochloride by virtue of its efficacy and tolerability could be considered as a drug of first choice and a welcome addition to the drug armamentarium for the symptomatic treatment of NUD (non-ulcer Dyspepsia) and other gastric motility disorders including functional bowel disorders. This review consists of various analytical methods for determination of Itopride Hydrochloride in various marketed pharmaceutical preparation and in biological fluids. Analytical method consists of various spectroscopic methods, chromatographic methods and other methods.

  • SNAKE BITE ITS FIRST AID & ANTI SNAKE VENOM (ASV): DETAILS GUIDELINES
    11 August 2014
    SNAKE BITE ITS FIRST AID & ANTI SNAKE VENOM (ASV): DETAILS GUIDELINES

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    ABOUT AUTHOR:
    Amitava Sinha Ray
    B.Pharmacy, DPM
    RANBAXY LABORATORIES LTD.
    West Bengal, India
    a.amitava.s@gmail.com

    ABSTRACT:
    Snakebite is an injury caused by a bite from a snake. It can be dangerous and life threatening if the snake will venomous. India is the top country having the highest no. of death due to snake bite. Some specific venomous snake is responsible for this death. Till now people are not serious about that. Most of the people don’t know just the first aid of snake bite. After a snake bite most village people are going to unqualified person and quacks for treatment not to hospital, this is one of the most serious causes of death. People should be aware about the sign and symptoms of snake bite and at least the first aid treatment of snakebite. In this type of emergency victim should be admit to nearest hospital and Anti Snake Venom (ASV) is very much necessary to save the patient life.

  • A REVIEW PAPER ON PSYCHIATRY DISORDERS & ITS TREATMENT BY AYURVEDIC APPROACH
    14 July 2014
    A REVIEW PAPER ON PSYCHIATRY DISORDERS & ITS TREATMENT BY AYURVEDIC APPROACH

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    ABOUT AUTHORS:
    Kuntal Pal1, Sampat Kumar Kundu2, Shatabisha Bhattacharjee2, Shounak Roy3
    1Institute of Medical Sciences, Rajiv Gandhi South Campus, Banaras Hindu University, Barkaccha, Mirzapur.
    2Gurunanak Institute of Pharmaceutical Sciences & Technology, Sodepur, West Bengal.
    3Birla Institute of Technology, Mesra, Ranchi, Jharkhand
    sampatkundu001@gmail.com

    ABSTRACT
    Psychiatric disorders are astonishingly common. In any given year, over 25 percent of adults have one or more diagnosable mental disorders, according to the National Institute of Mental Health. For the most part, psychiatric disorders are highly responsive to treatment. There have many ayurvedic plants/medicine which are effectively use for the psychiatric disorders. Ayurveda, being a stream of treatment, can no way ignore the importance of psychic condition of a patient to effectively diagnosis and treat disorders. Medical science admits that the root cause of multiple disorders lies in psychic tensions. Ayurveda too has a well developed branch of psychiatry, which has clinically proven practices of treating mental ailments and also physical problems associated with psychological imbalances. On a psychological level we naturally try to harmonies these problems but if we are not able to it can lead to a mental disorders. The causes are many but often stem from our own way of looking at things and the inability or unwillingness of our mind to process what is happening. Sometimes we just don’t want to let go of a belief or viewpoint. At other times we might be attached to a result and when something comes to challenge this, as life tends to do, we find our mind under stress in trying to work through the issue. On an unconscious level the mind may know what to do but at a conscious level the mind wants to do something else creating a conflict between the inner and outer, or the personality and the soul. The result often manifests as a Mental Disorder or sickness.

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