Review Articles

ABOUT AUTHORS
Diksha A. Narwade*, Dr. A. N. Aher
Department of Pharmacognosy,
MVP samaj college of pharmacy,
Gangapur road Nashik, Maharastra, India
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ABSTRACT
This paper gives the information about the Annona squamosa Linn. (Family: Annonaceae). Phytochemical and pharmacological studies of medicinal plant were performed. The plant is highly used traditionally for curing diverse diseases and disorders. It is locally known as “Sitaphal'' in Hindi. Macroscopical & microscopical studies of leaves have been studied. The phytochemical studies showed the presence of amino acids, terpenes, lipids, steroids, flavonoids, ascorbic acid, tannins, vitamins and alkaloids. The plant has various pharmacological actions such as insecticidal, purgative, laxatives, astringent, anti-inflammatory, antidiabetic, anti-ulcer, anti-oxidant, antimalarial and antibacterial. The reveiw specifically deals with the phytochemical and folkloric medicinal importance of plant.

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ABOUT AUTHORS
Suleman S. khoja * ¹, Dr. L J. Patel ², Sohil S. Khoja ³, Karim R. Panjwani ³, Jagdish Ray^3
1 PhD. Research Scholar, Ganpat University, Mehesana, Gujarat, India
² Faculty of Pharmacy, Ganpat University, Mehesana, Gujarat, India
³ Resource person, Pharmaceutical Quality Assurance, Audit and Compliance, Vapi, Gujarat, India

ABSTRACT
Good documentation constitutes an essential part of the quality assurance system and is key to operating in compliance with GMP requirements. Documentation requirements of maintaining complete, accurate, truthful and verifiable data in all cGXP documents that are needed to be maintained as per regulatory requirements and various Governmental regulations, laws, rules and statutes/acts. Documentation may exist in a variety of forms, including paper-based, electronic or photographic media. Ensure that the Document should be free from error and during any point if error identify then rectify with proper reason for correcting including sign and date. A system should be in place to indicate special observations and any changes to critical data. GMP Document must have predefined retention period and document must be stored in secure and easy to retrieve or easily available as and when required. Batch Processing and Packaging Instruction must be in place and Contemporaneous entry provision must be available. Instruction and procedure for using equipment; instrument must be clear and specific.  Specification with authorization should be available for analysis of Raw Material and Packing Material, Intermediate and Bulk Product, Finished Product.

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ABOUT AUTHORS
Patil N.B.*, Patil K.B., Wagh M.N., Patil A. A.
Department of Pharmacy,
Ahinsa Institute of pharmacy,
Dondaicha Tal-Shindakheda Dist-Dhule, Maharashtra, India

ABSTRACT
Indapamide is the Thiazide like diuretic drug used in treatment of Hypertension, as well as odema, Heart attack, stroke and heart failure in persons with high blood pressure. It is available in market single component and multicomponent formulations. The article summarizes 57 analytical method including the chromatographic method, LC-MS (Liquid Chromatography-mass spectroscopy), GC-MS (Gas chromatography-mass spectroscopy), spectriflurometric and UV Visible spectrophotometry techniques for estimation of   Indapamide in biological samples, bulk and pharmaceutical formulation.

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ABOUT AUTHOR
AK MOHIUDDIN
Faculty of Pharmacy, World University of Bangladesh

ABSTRACT
After liberation, Bangladesh pharma industry was largely dominated by the import dependent MNCs. On or before 1982 ordinance, 75% of the market was dominated by the MNCs and the rest share was with the other 133 local companies. After NDP formulation and the Drug Control Ordinance, there was a dramatic change of reverse. By 1994, a few pharma companies achieved a tremendous growth and they reinvest their profit for faster return. By next decade, Bangladesh is aiming to 30 world class drug manufacturers to establish strong footstep in global pharma market. Bangladesh, as an LDC got exempted from the obligation of patent and data protection in this arena until 2033. Interestingly, Bangladesh already passed across the LDC landmark to a developing country. So, there’s window of opportunity of more than a decade to grow further from that aspect.

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ABOUT AUTHORS
Kajal V. Kosankar*, Dr. A.N. Aher
MVP samaj college of pharmacy, Gangapur road Nashik, Maharashtra, India

ABSTRACT
Ficus racemosa it belongs to family Moraceae syn. Ficus glomerata Roxb. is the major group of angiosperm (flowering plant). They are widely distributed throughout Asia, Africa, America, Australia, Himalayan ranges, Punjab, Khasia Mountain, Bihar, Orissa, Rajasthan, Deccan, China, Indonesia and Malaysia. Udumber is used from ancient time for treating the many diseases. This tree is used traditionally for public health. It is also called yajnodumbara and grows all over the India at different areas. The common name is ‘Audumbar’ and ‘Umbar’ and used in Unani, Ayurveda and Homeopathy. The leaves tender are used in kalasha prokshana it is sprinkle water to different places from a scared copper mug and the bark is used in Homa. In review macroscopically studies, microscopically studies and chemical constituents are studied on different parts of the plant. Traditional uses and pharmacological uses are described, the extraction of leaves, fruit, stem, bark and latex are done due to this the important constituents are isolated in respective solvent like ethanol, methanol, acetone, petroleum ether, ethyl acetate and water. The more information is described below and the people are moving towards ayurvedic preparations.

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ABOUT AUTHORS
Mir Sahidul Ali¹, Souvik Mukherjee², Debayan Roy², Gargi Pal³, Subhajit Makar*^2
1Department of Chemical & Polymer Engineering, Tripura University (A Central   University), Suryamaninagar, Tripura 799022, India.
²School of Basic & Applied Sciences, Central University of Punjab,Bathinda-155110, Punjab, India.
³ Department of Pharmaceutical Sciences and Technology, NSHM Knowledge Campus, Kolkata- 700053, India.

ABSTRACT: Asparagus racemosus (A. racemosus) is a well-known medicinal plant due its various application in Ayurveda. It contains various type of secondary metabolite active natural products (or ingredients) such as steroids, alkaloids, flavonoids, furan derivatives and essential oils. In the present scenario due to growing catastrophic effect of diseases in human life, researchers are trying to stop synthetic drugs by replacing with herbal drugs. Herbal drug treatments are in general used to provide first-line and public health provider, both to persons abode in faraway areas the place it is the only on hand wellness service, and to people residing in bad areas the place it offers the one cheap relief. In this point of view A. racemosus can show a new path of herbal treatment.

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ABOUT AUTHORS
Pushpa latha E*1, Sailaja B2
1,2 Dept. of Pharm. Analysis & Quality Assurance, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Andra Pradesh, India-517502

ABSTRACT
Rizatriptan is a selective serotonin receptor agonist of the 1B and 1D sub types used in the acute treatment of migraine attacks. Effective analytical procedures are required for qualitative and quantitative determination of a drug. An extensive literature survey has been conducted in various analytical and pharmaceutical journals and the analytical methods which were developed and used for estimation of Rizatriptan in single or in combination with other drugs in bulk drugs, pharmaceutical formulations, biological fluids, stability indicating and impurity profiling methods have been reviewed. Various analytical methods used for the estimation of Rizatriptan reviewed in this paper includes Ultraviolet spectrometry, Visible spectrometry, High performance thin layer chromatography, High performance liquid chromatography, Liquid chromatography- mass spectrometry.

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ABOUT AUTHORS
R. Mishra¹, P. Barad¹, N. Patel², N. Patel³*
¹Department of Pharmacy,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat
²Department of Pharmacognosy,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat
³Department of Pharmacology,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat

ABSTRACT
Worldwide cancer is the major cause of death. Almost 8.8 million people died due to different types of cancer such as lung cancer, liver cancer, breast cancer, stomach cancer, blood cancer etc. in 2015. Government of various countries and some private organizations are spending trillions dollars for the research in cancer.  According to report of WHO treatment cost of cancer is approximately US$ 1.16 trillion per year and this amount is increasing per year. Despite of huge work the exact cause of genesis is still unknown. Couples of therapies like chemotherapy, radiation, surgery and targeted therapy are available with some detrimental effect. Now scientists are seeking lead molecule from naturally occurring substances due to high safety margin as compared to current approaches. Natural phytochemicals are prominent strategy for prevention, treating, and curing cancer. There are many phytochemicals from herbs having potent anticancer property. Generally these phytochemicals treat cancer by different mechanisms like augmenting apoptosis, cell cycle arrest, targeting to some specific cancer inducing proteins, increasing cytotoxicity etc. This is our little attempt to gather information of phytochemicals having anticancer property such as Etoposide, Curcumin, Vincristine, etc. with postulated mechanism. Etoposide is effective in lung cancer, ovarian cancer by inhibiting type II Topoisomerase. Various research revealed that Curcumin is effective in different types of cancers by increasing apoptosis and targeting specific gene such as MDM2 oncogene is inhibited through the ETS2 transcription factor by modulation of signaling pathway PI3K/mTOR in breast cancer. Vincristine shows anticancer property by oncogenic EWS-FLI1 fusion protein inhibition which cause G2-M phase cell cycle arrest & reduce tumor. This review depicts few phytochemicals having anticancer property such as Etoposide, Curcumin, vincristine, etc. with possible mechanism.

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ABOUT AUTHORS
S.Sarojini¹, B.Mounika,^2
1Department of Pharmaceutics, Shri Venkateshwara College of Pharmacy, Ariyur, Puducherry, India
²Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda, Telangana, India

ABSTRACT
Muntingia, or JamaicaCherry, is a small, fast growing tree that can reach up to 40 ft. tall at full maturity. The soft leaves are evergreen and have an alternate phyllotaxy. Leaves are dark green on top and light green underneath. The small, white flowers feature yellow stamens in the center. The small, round fruits are abundant, and depending on the variety, have a red or yellow color. Fruits are edible raw or made into jam. The fruit possessed potent anti-inflammatory activity. The flowers have antiseptic and antispasmodic qualities, and are made into medicinal teas. The M. calabura leaves exhibited potential anti-proliferative and antioxidant activities. The present study on Muntingia is to give an overview on traditional uses and pharmacological activity.