Nootan College of Pharmacy

About Authors:
Jigar Modi^*1, Dr. Jayvadan Patel¹, Dr. Hitesh chavda^2
1Nootan Pharmacy College, S.P. Sahkar Vidhyadham,
Kamana Crossing, Visnagar-384 315,
Dist – Mehsana, Gujarat, India.
²Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat, India
*jigo_farmacy@yahoo.com

ABSTRACT:
Generally, controlled release dosage forms used in many applications. Superporous hydrogel is also one of them. It has lot of advantages over conventional hydrogel. Superporous hydrogel having faster swelling due to interconnected highly porous structure. Such other properties like slippery property, their mechanical strength and better foaming process are advantageous over conventional hydrogel. Its unique mechanism for achieving gastric retention, a number of hurdles have to be overcome for any approach to be clinically useful. For example, intra-gastric floating systems require the presence of gastric juice to be effective, and this may not be the case in the fasted state. Mucoadhesive systems can easily lose their mucoadhesive properties by interaction with any materials soluble in gastric juice. In this review, types of superporous hydrogel, their preparation, their characterizations and applications are discussed.

About Authors:
Marvinkumar I. Patel*, Jyoti P. Patel, Ravi P. Patel, Hitesh P. Patel
Nootan Pharmacy College,
Visnagar, Gujarat
*patel.marvin62@gmail.com

Abstract:
Allicin is a novel molecule obtain from garlic. It is a molecule which is biologically active and give a good activity again so many disease in the treatment. It has mainly the virtu of killing the microorganisms which can not be killed by the regular antibiotics. It is not widely used in the pharmafield till today but widely used as food supplement but it has a wide scope to use as a novel tool to treat gastric cancer and microbial infection.

About Authors:
Marvinkumar I. Patel^*, Ravi R. Patel
Nootan Pharmacy College,
Visnagar,
Gujarat, India
*patel.marvin62@gmail.com

Abstract:
Dendrimer chemistry was first introduced in 1978 by Fritz Vogtle and coworkers. He synthesized the first “cascade molecules”, today known as dendritic molecules. The dendrimer architecture permits control over properties such as shape, size, density, polarity, reactivity and solubility. Dendrimer density functions and starburst limits can be easily modeled mathematically. Dendrimers have stimulated wide interest in the field of chemistry and biology, especially in applications like drug delivery, gene therapy and chemotherapy. A treatment of Cancer mainly focused on the targeting the active drug molecule at the site without affecting the neighbour cells and dendrimers have this property which is useful in diagnosis and treatment purpose which is a new hope in this area of Cancer treatment.

About Authors:
Kalpesh N. Patel¹*, Jayvadan K. Patel^2
1 Research Scholar, Jodhpur National University, Jodhpur,
Rajshathan, India
² Department of Pharmaceutical Technology,
Nootan Pharmacy College,
Visnagar (GUJARAT), India.

Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of pyrimethamine and sulphadoxine from tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 215 nm (λmax of pyrimethamine) and 254 nm (λmax of sulphadoxine) in methanol and Method-II first order derivative spectroscopic method involves the measurement of absorbances at two wavelengths 250 nm (λmax of pyrimethamine) and 220.5 nm (λmax of sulphadoxine); The linearity lies between 5-30 µg/ml for both pyrimethamine and sulphadoxine for all the two methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of pyrimethamine and sulphadoxine in bulk and combined dosage form.

About Authors:
RAVIKUMAR R. PATEL¹, Dr. JAYVADAN K. PATEL^2
1 Research Scholar, Jodhpur National University, Jodhpur
² Principal and Professor, Nootan Pharmacy College, Visnagar, Mehsana, Gujarat.

AIM OF PRESENT INVESTIGATION
Now a day most of the pharmaceutical scientists are involved in developing an ideal drug delivery system with an objective of not only curing the disease but also to achieve patient compliance. Approximately 50 % of the drug delivery system available in market is oral drug delivery system. Conventional oral dosage forms provide a specific drug concentration in systemic circulation without offering any control over drug delivery. Over the past three decades, the pursuit and exploration of devices designed to be retained in the upper part of gastrointestinal tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems.