Mehsana

Aabout Author:
Dhirendra C. Patel*
Master of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology,
S.K. Patel College of Pharmaceutical Education and Research, Ganpat University,
Kherva, Mehsana, Gujarat, India.
dhiren.pharmacy@gmail.com

Abstract:
Herbal medicines are very popular in treatment of the asthma in the modern era because of lots of benefits of it like less cost, less side effects, easily available etc. Herbal alternatives to asthma are better way for treatment of asthma. Various herbal medicines recognize that immune system functioning can play a vital role in helping to control the symptoms of asthma and strengthen the body's defenses against environmental allergens. Herbal medicines like ephedra, ginger, chamomile, elderberry, licorice, mullein, stinging nettle etc are very beneficial in asthma. Scientists have found evidence to support herbal's wide range of medicinal actions. These actions include the lowering of cholesterol levels, relief for allergies and asthma etc. Herbs have been used by people for longer than we have been keeping written record. Originally they were found in the wild by the gatherers and used for lots of different things. I light here, the use of herbals in asthma. It aims to tap into the body’s own healing mechanism by transforming the “triggers” of such attacks as part of the remedy. Opinions of different authors are saying that herbal medication is better way for asthma treatment.

About Authors:
K.S.Khatri
S.K.Patel education and research, Kherva,
Mehasana-384001
kkhatri_pharm@yahoo.com

Abstract:
Interest in transdermal drug delivery systems has increased on several fronts over the past several years because of the inherent advantages over the oral delivery such as the avoidance of gastrointestinal absorption, enzymatic and pH associated deactivation. Stratum corneum forms highly lipophilic membrane and provides the greatest resistance to penetration of drugs. A number of chemical and physical permeation enhancement techniques have been investigated. Chemical enhancers represent the most widely studied approach to transdermal drug permeation enhancement but are associated with toxicity, therefore limiting their clinical application. In recent years the emergence of number of physical techniques has expanded the range of drugs that can be delivered transdermally. Promising new technologies involved in enhancing transdermal permeation are Abrasion, Electroporation, Sonophoresis/Phonophoresis, Pressure waves, Iontophoresis, Laser Radiation,Magnetophoresis, Microneedles, Needleless injection and many more. In the present reviewed tried to discuss alternate techniques of enhancing the transdermal transport.

About Authors:
Kalpen N. Patel*, Maulika S. Patel, Divya Thakkar, Manan Patel, Kaushal Raval
Shree Krishna Institute of Pharmacy, Shankhalpur,
Bechraji, Mahesana, Gujarat, India.
*kalpenpharma@gmail.com

ABSTRACT
Sustained releases tablets have been used for reduced the dosing frequency and maintain the plasma drug concentration level within narrow therapeutic range. Aspirin used as antiplatelate agent and Atorvastatin is HMG-CoA reductase inhibitor which lowers the plasma concentration of cholesterol. Here in present study sustained release tablets of Aspirin and Atorvastatin prepared by using cellulose acetate phthalate (CAP) and microcrystalline cellulose (MCC) as a polymers. The sustain release tablet of Aspirin And Atorvastatin were prepared by wet granulation method and were substituted for film coating to mask the spotting from Atorvastatin and for protection from light. From the dissolution profile of F2B2 gives controlling the release up to 12 hrs with required value i.e. - 55.85 % for Aspirin and 54.78 % for Atorvastatin in 4 hrs respectively and 100.70 % for Aspirin and 100.60 % for Atorvastatin in 12 hrs respectively. The result of stability studies of batch F2B2 indicate that it is stable at 400C / 75 % ±0.5 % relative humidity as there was no significant differences observe for dissolution and average drug content data after two months.

About Authors:
Jigar Modi^*1, Dr. Jayvadan Patel¹, Dr. Hitesh chavda^2
1Nootan Pharmacy College, S.P. Sahkar Vidhyadham,
Kamana Crossing, Visnagar-384 315,
Dist – Mehsana, Gujarat, India.
²Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat, India
*jigo_farmacy@yahoo.com

ABSTRACT:
Generally, controlled release dosage forms used in many applications. Superporous hydrogel is also one of them. It has lot of advantages over conventional hydrogel. Superporous hydrogel having faster swelling due to interconnected highly porous structure. Such other properties like slippery property, their mechanical strength and better foaming process are advantageous over conventional hydrogel. Its unique mechanism for achieving gastric retention, a number of hurdles have to be overcome for any approach to be clinically useful. For example, intra-gastric floating systems require the presence of gastric juice to be effective, and this may not be the case in the fasted state. Mucoadhesive systems can easily lose their mucoadhesive properties by interaction with any materials soluble in gastric juice. In this review, types of superporous hydrogel, their preparation, their characterizations and applications are discussed.

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B S Patel Pharmacy College   offers four year B Pharm Degree programme at the undergraduate level with intake of 60 every year..

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About Authors:
Kalpesh N. Patel¹*, Jayvadan K. Patel^2
1 Research Scholar, Jodhpur National University, Jodhpur,
Rajshathan, India
² Department of Pharmaceutical Technology,
Nootan Pharmacy College,
Visnagar (GUJARAT), India.

Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of pyrimethamine and sulphadoxine from tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 215 nm (λmax of pyrimethamine) and 254 nm (λmax of sulphadoxine) in methanol and Method-II first order derivative spectroscopic method involves the measurement of absorbances at two wavelengths 250 nm (λmax of pyrimethamine) and 220.5 nm (λmax of sulphadoxine); The linearity lies between 5-30 µg/ml for both pyrimethamine and sulphadoxine for all the two methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of pyrimethamine and sulphadoxine in bulk and combined dosage form.