Mehsana

About Authors:
Jigar Modi^*1, Dr. Jayvadan Patel¹, Dr. Hitesh chavda^2
1Nootan Pharmacy College, S.P. Sahkar Vidhyadham,
Kamana Crossing, Visnagar-384 315,
Dist – Mehsana, Gujarat, India.
²Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat, India
*jigo_farmacy@yahoo.com

ABSTRACT:
Generally, controlled release dosage forms used in many applications. Superporous hydrogel is also one of them. It has lot of advantages over conventional hydrogel. Superporous hydrogel having faster swelling due to interconnected highly porous structure. Such other properties like slippery property, their mechanical strength and better foaming process are advantageous over conventional hydrogel. Its unique mechanism for achieving gastric retention, a number of hurdles have to be overcome for any approach to be clinically useful. For example, intra-gastric floating systems require the presence of gastric juice to be effective, and this may not be the case in the fasted state. Mucoadhesive systems can easily lose their mucoadhesive properties by interaction with any materials soluble in gastric juice. In this review, types of superporous hydrogel, their preparation, their characterizations and applications are discussed.

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About Authors:
Kalpesh N. Patel¹*, Jayvadan K. Patel^2
1 Research Scholar, Jodhpur National University, Jodhpur,
Rajshathan, India
² Department of Pharmaceutical Technology,
Nootan Pharmacy College,
Visnagar (GUJARAT), India.

Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of pyrimethamine and sulphadoxine from tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 215 nm (λmax of pyrimethamine) and 254 nm (λmax of sulphadoxine) in methanol and Method-II first order derivative spectroscopic method involves the measurement of absorbances at two wavelengths 250 nm (λmax of pyrimethamine) and 220.5 nm (λmax of sulphadoxine); The linearity lies between 5-30 µg/ml for both pyrimethamine and sulphadoxine for all the two methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of pyrimethamine and sulphadoxine in bulk and combined dosage form.

About Authors:
RAVIKUMAR R. PATEL¹, Dr. JAYVADAN K. PATEL^2
1 Research Scholar, Jodhpur National University, Jodhpur
² Principal and Professor, Nootan Pharmacy College, Visnagar, Mehsana, Gujarat.

AIM OF PRESENT INVESTIGATION
Now a day most of the pharmaceutical scientists are involved in developing an ideal drug delivery system with an objective of not only curing the disease but also to achieve patient compliance. Approximately 50 % of the drug delivery system available in market is oral drug delivery system. Conventional oral dosage forms provide a specific drug concentration in systemic circulation without offering any control over drug delivery. Over the past three decades, the pursuit and exploration of devices designed to be retained in the upper part of gastrointestinal tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems.

The college "Saraswati School of Pharmacy" is located at- Ranela, Mahesana. This college runs B. Pharm course in the college campus. The college is run by Shree B. M. Patel Education Trust. This is one of the largest educational campus running professional institutions in the University, to which it is affiliated with. It offers educational course.

About Author:
D. J. Kalena^*, C. N. Patel
Department of Quality Assurance,
Shri Sarvajanik Pharmacy College,
Near arvind baug, Mehsana - 384 001, Gujarat, India

A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of atorvastatin calcium and olmesartan medoxomil in combined dosage forms. The stationary phase used was TLC aluminium plate precoated with silica gel 60F₂₅₄. The mobile phase used was a mixture of acetonitrile: chloroform: methanol: 10% glacial acetic acid (7: 2: 1.5: 0.1 v/v/v/v). The system was found to give compact spot for both atorvastatin and olmesartan (R_f value 0.5±0.01 and 0.76±0.02 respectively). The densitometric analysis of spot was carried out in reflectance mode at 253 nm. The method was validated in terms of linearity, specificity, precision, robustness and accuracy. The calibration curve was found to be linear in the range of 200 to 800 ng/spot for atorvastatin and 400 to 1600 ng/spot for olmesartan. The limit of detection and the limit of quantification for the atorvastatin were found to be 178.239 and 540.11 ng/spot and for olmesartan 40.10 and 121.51 ng/spot, respectively. The proposed method can be successfully used to determine the drug content of marketed tablet formulation.