Pharmacology

About Authors:
A. Srilakshmi, SK. Afsar, B. Priyanka, G. Jyothi Reddy, R.E.Amrutha, B.Jagadeesh babu, C. Raja ram
1. Department of Pharmacology,
P. Rami Reddy Memorial College of Pharmacy,
Kadapa, Andhra Pradesh, India.

ABSTRACT
ALLOPHYLUS SERRATUS is a medicinal plant used for the treatment of various risk factors like analgesia, inflammation, ulcers, and wounds. The aqueous extract of the leaf was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 100, 200 and 400mg/kg body weight reduced significantly the formation of oedema induced by formalin. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 0.05ml of 10% formalin. These results were also comparable to those of ibuprofen, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations.

Established under the Act Of State Government- “The Rajasthan University Of Health Sciences Act, 2005” (Act No. 1 of 2005)”on 25 day February, 2005, the University aims to disseminate and advance knowledge in medical and health sciences.

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The Training and Development effort at Colgate-Palmolive is a direct outcome of the Individual Development Plan and the Business need. The business critical and individual specific needs are identified every year and a training needs inventory is drawn up.

About Authors:
Kapil Patel, Supriya Hazra Das
Department of Pharmacology
Shree Dhanvantary Pharmacy College,
Kim, Surat – 394118,
Gujarat, India

Abstract:  
Peptic ulcer is a condition where benign lesions of gastric or duodenal mucosa occur at a site where the mucosal epithelium is exposed to acid and pepsin, due to imbalance between offensive and defensive factors. Acacia leucophloea, a deciduous tree found throughout India is reported to be used in gastric ulcer in traditional medicine. The present study was undertaken to evaluate the anti-ulcer properties of Acacia leucophloea in pylorus ligation ulcer model in rats. Acacia leucophloea was administered for 7 days and on 8^th day 30 min prior to the induction of ulcers. Pretreatment with Acacia leaucophloea showed significant ulcer protection against pylorus ligation ulcer model as compared to control. Thus, the ulcer protective and healing effects of Acacia leucophloea may be due to its effect on both offensive and defensive factors. The present findings suggest that Acacia leucophloea has antiulcer properties.

Pharmacopoeia Commission for Indian Medicine (PCIM) is an autonomous body established in 2010 with the approval of Govt. of India with an objective to develop Pharmacopoeial standards for Ayurveda, Siddha and Unani drugs and to publish Ayurvedic, Unani and Siddha Pharmacopoeia of India for the promotion of Quality and Safety of ASU Drugs for the furtherance of provisions of Chapter-IV of Drugs and Cosmetics Act-1940 and Rules-1945 of Ayurvedic, Unani and Siddha drugs.

About Authors:
NIKHIL SAXENA, DR.K.R.PARDASANI, DR.USHA CHAUHAN
MAULANA AZAD NATIONAL INSTITUTE OF TECHNOLOGY,
BHOPAL

ABSTRACT
The electro negativity of the drug directly resembles its chemical nature towards the receptor. In order to achieve the desired response, the effective binding of drug is necessary. Based on the Lock key theory, every drug having a specific structure so that it can bind to a specific receptor. But for designing more efficient a new chemical entity for receptor as compared to the main drug, there is a requirement of some structural changes in the drug (ligand) molecules under structure activity relationship concept. 
Here an attempt has been made to develop Insilco approach to make some structural changes on the basis of point mutation (changes occurs at a particular point) in the antiasthmatic drug namely salbutamol.
The effect of this mutation on binding affinity of the molecule is studied using docking energy (energy involved in orientation of one molecule to a second are when bound to each other to form a stable complex) calculations and logp values. Here eight different structures of the drug found are more electronegative as compared to the main drug candidate. Mutation was made at C-3a position in place of hydrogen. These were analyzed for binding affinity with target receptor. The mutated molecules which have high logp values and less energy are selected for further adme properties studies. Thus after prediction all adme properties and toxicity studies of the mutated drugs, the best mutation was bromine in place of hydrogen at C-3a position.