Pharmacology

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About Authors:
Revathy subramani, Anand M., Muralidharan P.
Department of pharmacology,
C.L. Baid metha college of pharmacy,
Thoraipakkam, Chennai 600097,
India

Abstract
Obsessive Compulsive Disorders (OCDs) involve habitual, repetitive behaviors that can be bizarre, disruptive and eventually disabling and it is characterized by intrusive thoughts. Aim of this study is to investigate the methanolic extracts of convolvulus pluricaulis (MECP) action on OCD with animal models by using invivo pharmacological evaluations such as Marble burying behavior, Hole board test, Rota-rod test using mice. These tests are well-accepted paradigm to screen anti-compulsive activity and it also reflects an anxiety-like responses. In this study we used seven groups of mice all the three tests were made on the seven groups. First group serves as control. Second and third groups were treated with 15 mg/Kg and 30 mg/Kg of fluoxetine which is a standard drug and also it is a selective serotonin reuptake inhibitor (SSRIs). Then fourth and fifth groups were treated with 2.5 mg/Kg and 5 mg/Kg of diazepam which is an anxiolytic-sedative drug useful in the symptomatic relief of anxiety and tension states it serves as a negative control. Sixth and seventh groups were treated with 200 mg/Kg and 400 mg/Kg MECP the results show that the MECP can modulate serotonin or dopaminergic levels, which is the major pathway of OCD pathophysiology. Involvement of the serotonergic or dopaminergic receptors for its effect on OCD has been planned based on this study.

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About Author: Rinki Verma (Research fellow)
Institute of Medical science (CEMS)
Banaras Hindu University
Varanasi - 221005

Abstract:
Gallbladder cancer is a comparatively rare cancer and has poor outcome due to their anatomy and location. It has peculiar geographical distribution being common in central and South America, central and eastern Europe, Japan and northern India; it is also common in certain ethnic groups e.g. Native American Indians and Hispanics (Kapoor VK, McMichael AJ ,2003. It is fifteen uncommon cancers in the world with high mortality rate. The diagnosis is made very late due to its silent course. The majority of patients have advanced disease at the time of presentation which carries a poor prognosis. The modes of spread of gall bladder carcinoma are direct, lymphatic, vascular, neural, intraperitoneal and intraductal. Ultra Sound, CT and MRI are helpful in diagnosis and staging of the disease. Surgery remains the mainstay of treatment and chemotherapy has a very limited role.