Pharmacology

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai. Since its inception in 1970, it has been making vigorous efforts to improve the reproductive health of people through research, education and health care services.

Gandhi Institute of  Technology and Management,  popularly known as GITAM was founded in 1980 by an inspired group of eminent intellectuals and industrialists of Andhra Pradesh led by Dr. M.V.V.S.Murthi, Former Member  of  Parliament  and popular philanthropist.   Their mission was to set up a  world-class technology &nbsp

Recruitment applications are invited On-line through the proforma Application to be made available on WEBSITE (apspsc.gov.in) in from 22/02/2012 to 22/03/2012 (Note: 20/03/2012 is the last date for payment of fee) for recruitment to the post of Drug Inspector in A.P. Drugs Control Administration Service.

About Authors:
Richa Sood
CTIPS,Jalandhar,
India.

Abstract:
The renin-angiotensin system (RAS) plays an important role in the pathogenesis and worsening of heart failure(HF). Recently developed class of drug, angiotensin receptor blockers (ARBs) block the RAS at the receptor level, and may therefore provide more complete blockade. Angiotensin II Receptor type 1 antagonists have been widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. Their beneficial effects are related to inhibition of Angiotensin II by blockade of AT1 receptor. Valsartan is an orally active Angiotensin II receptor type 1 antagonist which causes reduction in blood pressure and is used in treatment of hypertension. It was first developed by Novartis and has wide market in the developed and the developing countries.

Pondicherry University is outstanding among the Central Universities in India. Teaching and research are its primary functions as in other Central Universities. In addition, it has also affiliated colleges located in Puducherry, Karaikal, Mahe, Yanam and the Union Territory of Andaman & Nicobar Islands. The Union Territory of Lakshadweep is also expected to have a college affiliated to Pondicherry University in the near future.

A new education era in Shadnagar region has been started when Moonray Institute Of Pharmaceutical Science, founded by Moonray Education Society , established in the year 2008. Eminent educationalists from Hyderabad having a reputed academic track record of 20 years formed the governing body of the College.

ABOUT AUTHORS:
G. JYOTHI REDDY*¹, A. SRILAKSHMI¹, S.SINDHUJA², N.K. SREE¹, SK.AFSAR¹, B.PRIYANKA¹, R.E.AMRUTHA^1
1 Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
² Sri Padmavathi School Of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India

ABSTRACT
The ethanolic leaf extract of Allophylus serratus shown significant (p<0.05) antidiarrheal activity on gastrointestinal motility with  castor oil- induced diarrheal model in rats. The results obtained revealed that the leaf extract possess pharmacological activity against diarrhoea and may possibly explain the use of the plant in traditional medicine. The extract tested at 200 and 400 mg/kg like the standard drug, loperamide significantly inhibited the frequency of defecation droppings compared to untreated control rats. This result is in support of previous claims in respect of antidiarrhoeal herbs.