Tamil Nadu

9 January 2013

Opening for Business Heads in Akumentis Healthcare - High Profile Job

Akumentis have strong back up of world class manufacturing & R&D facilities. The manufacturing facility is 3rd largest in Asia with WHO GMP, ISO 9001, ISO14001, USFDA & UKHMRA certifications. we have 1000 innovative products in pipeline.

Post: Business Heads- Chennai
9 January 2013

Applications are invited for Entrance Examination for admission to Ph.D. Programme (Part Time) in Sri Ramachandra University

Sri Ramachandra University was established in the year 1985 as part of the Sri Ramachandra Education & Health Trust under the leadership of Shri N.P.V. Ramasamy Udayar. Ever since its inception, the institute grew from strength to strength gaining the status of a "Deemed University" in September, 1994 under Section 3 of the University Grants Commission Act, 1956.
6 January 2013

TOTAL PHENOLIC AND FLAVONOID CONTENT OF DIFFERENT EXTRACTS OF INDIGOFERA TINCTORIA LINN

About Authors:
Nagasaraswathi.M*, Rafi khan.P, Aleemuddin.MA, Gopi Chand.K, Nagaprashanthi.Ch
Faculty of Pharmacy, PRIST University,
Thanjavur-614901, Tamilnadu (INDIA)
abdulaleemuddin@gmail.com

ABSTRACT
The importance for medicinal herbs is increasing day by day due to its high availability and lower side effects. The present study investigated the total phenolic and flavonoid content of various extractions of Indigofera tinctoria linn. The total phenolic content was determined by folin-ciocatechu reagent using Gallic acid as standard and total flavnoid content by aluminium chloride assay using Quercetin as a standard. The present study showed the ratio of phenolic and flavonoid content in different extracts of Indigofera tinctoria linn. Aqueous extract showed the more flavonoid and phenolic content in comparision with other extracts.
26 December 2012

Franco-Indian Pharmaceuticals invites Regional Sales Managers, Area Sales Managers, Trainee Medical Representatives

Franco-Indian Pharmaceuticals Pvt. Ltd., a name that stands for quality and innovation, is one of the major players in the Pharmaceutical Industry in India.
Our innovative, value added products improve the quality of life of people and ease their sufferings and help them to enjoy, longer, healthier and more productive lives.
23 December 2012

NATIONAL FACILITY ON DRUG DEVELOPMENT invites M.Pharm and Ph.D as Research Associate, Junior Research Fellow

Anna University Chennai Regional Office Tiruchirappalli (Formerly Anna University Tiruchirappalli) has been established as a Annal University Chennai Regional Office Tiruchirappalli by the Government of Tamilnadu. The Regional Office is functioning from 01-08-2012 at Tiruchirappalli, which is famously known as Rock Fort city. The Regional Office is situated 17Kms away in the main highway of Tiruchirappalli to Pudukkottai.
22 November 2012

FORMULATION AND EVALUATION OF CINITAPRIDE TABLETS AS FLOATING DRUG DELIVERY SYSTEM

About Authors:
S.Dinesh*, M.Senthil Kumar, Ashok kumar, Hariharan, jenish, Marshal joseph
Annai veilankanni’s pharmacy college
saidapet, chennai – 600 015.
Tamil nadu, pin:600015
*dinesh.pharmacy@gmail.com

ABSTRACT
Cinitapride1-2, chemically4-amino-N[3-(Cyclohexan-1-yl-methyl)-4-piperidinyl]-2-ethoxy-5-nitrobenzamide has the molecular formula C₂₁H₃₀N₄O₄ and molecular weight 402.49 g.Cinitapride is a drug that has against action to the serotoninergic 5-HT₂ and D₂ dopaminergic receptors that has been indicated in the gastro esophageal reflux and in the functional disorders of gastrointestinal motility treatment, The present study was aimed to formulate and evaluvate the tablets containing Cinitapride based on floating technique in order to increase gastric retention time, Total 9 formulation (F1-F9)were done using 3 different polymers like (HPMC k4m, HPMC e15m and HPMC k100m ). The formulations prepared were subjected to dissolution tests for 12 hrs, Among all the 9 formulation formulation (F5) were able to efficiently control Cinitapride release over a time period of 12 hrs. Thus the results of the current study clearly indicate, a promising potential of the floating tablet as an alternative to conventional dosage form.
21 November 2012

FORMULATION AND EVALUATION OF FLOATING TABLETS USING ALFUZOSIN HYDROCHLORIDE AS A MODEL DRUG

About Authors:
Jenish.R*, M.Senthil kumar, Dinesh, Ahokkumar, Marshel, Hariharan
Annai veilankanni’s college of pharmacy
Saidapet, Chennai-600015
Tamilnadu
*jenishnathan@gmail.com

ABSTRACT
Alfuzosin is a non-subtype specific alpha(1)-adrenergic blocking agent that exhibits selectivity for alpha(1)-adrenergic receptors in the lower urinary tract. Inhibition of these adrenoreceptors leads to the relaxation of smooth muscle in the bladder neck and prostate, resulting in the improvement in urine flow and a reduction in symptoms in benign prostate hyperplasia. Alfuzosin also inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. The alfuzosin of the present investigation is designed to retain in the stomach and deliver the drug alfuzosin for longer periods of time. The developed floating provides increased absorption of the alfuzosin at a rate such that effective plasma levels can be achieved and maintained for a prolonged duration. Formulations 6 displayed drug release considered in 0.1N HCL and Formulation 6 shows better drug release in dissolution profile.
11 November 2012

STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR CINACALCET HYDROCHLORIDE API

About Authors:
Gautam Kumar
SRM college of pharmacy, SRM University
Chennai 600 033.
gautamsinghsrmcp@gmail.com

Abstract
The aim of the present work to develop validated RP-HPLC method which determines stress stability and concentration of Cinacalcet hydrochloride in synthetic mixture as per ICH guidelines. Separation was performed using Camag Linomat V semi Automated sample applicator with TLC Scanner III. Stationary Phase consisting of TLC plates (Merck) pre coated with silica gel 60F₂₅₄ on Aluminum Sheets was used. Mobile phase comprising of Methanol: Water: Glacial acetic acid (5:5:0.2v/v/v) was used. All the system suitability parameter was found within the range. The method was extensively validated for specificity, linearity, accuracy, precision, recovery, limit of quantitation and detection. The Cinacalcet hydrochloride was found to be highly labile to alkaline and acid hydrolysis compared to oxidation. Chromatographic peak purity results indicated the absence of co-eluting peaks with the main peak of Cinacalcet, which demonstrated the specificity of assay method for estimation of Cinacalcet in presence of degradation products. The proposed method can be used for routine analysis of Cinacalcet in quality control laboratories.
8 November 2012

HBL invites Deputy Manager - Formulation, Production, QA, QC, Regulatory Affairs, Animal House

HLL Biotech Limited (HBL) is a 100% subsidiary of HLL Lifecare Limited, a Mini Ratna Schedule B Central Public Sector Enterprise under the Ministry of Health & Family Welfare. HBL is setting up a vaccine complex at Chengalpett, Chennai for manufacturing of Bacterial and Viral Vaccines & developing a strong R&D base for vaccine technologies within the country.
5 November 2012

PREPARATION OF VILOXAZINE SUSTAINED RELEASE DRUG DELIVERY SYSTEM BY USING ETHYLCELLULOSE, CARBOPOL, SODIUM ALGINATE, HYDROXY PROPYL METHYL CELLULOSE & GUAR GUM

About Authors:
D. HariHaran*, M. Senthil kumar, M. Ashok Kumar, S. Dinesh & R.Jenish.
Annai Veilankanni’s College of Pharmacy,
81, V.G.P. Salai, Saidapet, Chennai-600015.
*haran_pharma@yahoo.com

ABSTRACT
The present study behind this work is to find to prepare sustained release tablets of Viloxazine by compression method. First of all to formulate Viloxazine sustained release tablets using the Ethylcellulose, Carbopol, Sodium Alginate, Hydroxy propyl methyl cellulose & Guar gum under ratio’s like 1:1, 1:1, 1:1,1:1,1:1 . Five batches were made in various polymers of ethylcellulose, carbopol, sodium alginate,hydroxy propyl methyl cellulose & guar gum is used by keeping the drug as constant. Then evaluation of Viloxazine sustained release tablets was carried out for characteristics like drug content in tablet, UV analysis. In vitro release starts from 1hr and up to 24hrs. It shows the percentage of gradual drug release as 17.80%, 27.65%, 35.12%, 45.16%, 51.20%, 57.42%, 61.30%, 66.32%, 72.08%, 77.15%, 81.32%, 84.48% & 98.20% against the label claim as 40mg.