Tamil Nadu

About Authors:
Rambabu.CH*, V. V. V. S. P. Apparao, Miss. M.  Muthulakshmi, V. Ananth.
aPG-Student, Department Of Pharmaceutical Analysis,
KMCH College of Pharmacy,
Kalapatti Road, Coimbatore– 641 048, INDIA.
*ramgepharma@gmail.com

ABSTRACT:
At present, simultaneous determination of drugs in the combination dosage forms has been enjoying renaissance in the field of pharmaceutical analysis. Paracetamol, a classical antipyretic in combination with a novel antispasmodic drug, drotaverine hydrochloride provides a synergistic effect in the treatment of spasms. From the reviewed literature, it was simultaneous uv-spectrophotometric methods have not yet been developed for the determination and quantification of paracetamol and drotaverine hydrochloride. The λmax of paracetamol is 257 nm and that of drotaverine hydrochloride were scanned and found to be 308 nm, 352 nm. Both paracetamol and drotaverine hydrochloride were found to have significant absorbance of the λmax   of each other and total absorbance was equal to the sum of the absorbance of paracetamol and drotaverine hydrochloride individually measured. So the present study involves the uv-spectrophotometric method development for the simultaneous determination of paracetamol and drotaverine hydrochloride by using simultaneous equations method. The mean % recoveries from this method were found to be 100.76% and 100.17% for paracetamol and drotaverine hydrochloride respectively proving that the method is accurate.

About Authors:
Segu Sairam*, Mulla Mahaboob Basha, S Ananda Thangadurai, V Kranthi kumar
Swamy vivekanandha college of pharmacy, dept. Of pharmaceutical analysis,
Elayampalayam, tiruchengode – 637205.
*Sairampharma2020@gmail.com

ABSTRACT
A simple, sensitive and specific method reverse phase - high performance liquid chromatography (RP-HPLC) have been developed and validated for the estimation of Temozolomide in its Pharmaceutical dosage form.
Estimation of Temozolomide by using RP-HPLC coupled with UV
An isocraticREVERSE PHASE - HIGH PERFORMANCE LIQUID CHROMATOGRAPHY method was developed and validated for the estimation of Temozolomide in its Pharmaceutical dosage forms. The separation of the analytes was performed on aDevelosil ODS MG.5 (150×4.6mm),5µm, with mobile phase containing (0.5% w/v glacial acetic acid) named as Solution-A  :  Methanol  [90 : 10, v / v] was used. The flow rate was 1 ml min^-1 and separation was monitored by UV detection at 254 nm. Chromatogram showed peak at a retention time of 7.306 ± 0.009 min. validation of the method for linearity and range, intra-day and inter-day precision, accuracy, specificity, recovery, ruggedness, robustness and limits of detection and quantification were obtained as 0.598 µg / ml and 1.81 µg / ml respectively. The calibration plot was linear from 20-60 µg ml^-1 and the correlation coefficient was 0.999.The proposed method is fast, accurate and precise for the quantitative determination of Temozolomide capsules.

About Authors:
*Anton Vinoth.T , Prof .K. Nagarajan , Mr. Manikandan
Department of Pharmacy practice, K.M College of Pharmacy,
Madurai, Tamilnadu
*vinoth.anton@gmail.com

ABSTRACT:
Mood disorders (affective disorders) are among the most common mental disorders encountered in clinical practice and divided into bipolar disorders and depressive disorders. The essential feature of these disorders is a major disturbance in mood. Depression is common, affecting about 121 million people world wide. At its worst depression can lead to suicide, a tragic fatality associated with the loss of about 85000 lives every year. By the year 2020, depression is projected to reach the second Major depression is among the most common mental disorders encountered in clinical practice. The problems associated with depression can become chronic or recurrent and lead to substantial impairment in an individual’s ability to take care of his or her everyday responsibilities. At its worst depression can lead to suicide, a tragic fatality associated with the loss of a large number of lives every year. Depression is the leading cause of disability as measured by YLDs and the leading contributor to the global burden of diseases (DALYs) in 2000.

The present study is done as it is the role of a clinical pharmacist to evaluate the efficacy and safety of the drugs acting through specific antidepressant mechanisms and to assess the possibility of matching patient symptom profile with antidepressant mechanism to achieve more rapid response or greater efficacy.

The aim of the study is tocompare the efficacy of Citalopram and Escitalopram in the Major Depressive Disorder Patients during the first 8 weeks (acute phase) of treatment.

About Authors:
Swathi sree Karumuri^*, Venkata Naveen Kasagana
Department of Pharmaceutics,
Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam,
Sivakasi - 626 130, Tamilnadu, India
*swathi.karumuri2011@gmail.com

Abstract:
New drugs pursuing novel delivery technologies with the objective of improving drug safety, efficacy and site Targeting in a cost effective way has been a challenging area of work for researchers. Their eminent work in the field of Novel technology has introduced many drug delivery methods to fulfil the requirements of pharmaceutical manufacturers and customers. Multiunit particulate systems (MUPS) are novel MDDS techniques that have gained importance, not only because of their ability to control drug release, but also for the modified drug-release profiles they facilitate. Similarly Acoustic targeted drug delivery (ATDD) is a method that uses ultrasound energy to enhance the transport of molecules into and/or across specific tissues. P.L.E.A.S.E. (Painless Laser Epidermal System) is a transdermal delivery device that uses a special laser source to create micro pores in the skin through which high molecular weight drugs are delivered painlessly in a highly controlled and accurate fashion. Oral delivery of insulin with increased lipophilicity across the gastrointestinal epithelium by the application of Eligen technology. Development of nanorobots with biosensors for medical target identification and drug delivery plays a prominent role in the diagnosis and treatment of Diseases. Gene delivery technology that turn off or on gene responsible for causing diseases like cancer and diabetes. The present article describes how Novel Drug delivery fulfils the Patient Needs on a Global Level and forms a key technology in the field of pharmaceuticals.

About Authors:
Venkata Naveen Kasagana*, Swathi sree Karumuri
Department of Pharmaceutics
Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam,
Sivakasi - 626 130, Tamilnadu, India.
*naveen.kasagana@gmail.com

Abstract:
In the recent past global pharmaceutical markets has involved in developing the new Novel and Advanced drug delivery systems in a safe & cost effective manner. This resulted in the introduction of a variety of Controlled and Targeted drug delivery methods with ease of administration and patient compliance. The transition that took place by the introduction of nano technology in the field of pharmacy leads to the development of many intelligent drug delivery systems like Nano Beacon and Mini Beacons, Trojan horse Nano particles, MEMS & NEMS (Micro and Nano Electromechanical Systems). Cochleate delivery vehicles “A novel lipid-based system” represent a unique technology platform for oral and systemic delivery of drugs. BEMA (Bio Erodible Muco Adhesive Disc) drug delivery technology for prolonged acting action has contribution to the novel approach. Also a much awaited Non-injected insulin formulation “Nasal Insulin spray”, as a vaccine and also in the treatment of Type-II diabetes, provided a shift in the development of drug delivery systems. Duocap (Capsule-in-a-capsule), Electro capsule, Light up delivery monitoring technology (LDMT) are some of the controlled & targeted oral drug delivery systems, which provides a new way of formulating poorly soluble compounds and monitor the release rate of the drug. Apart from briefly describing the above technologies, the article includes the upcoming system of using Air as a barrier for Controlled release and application of medical devices as drug and their contribution to the World of pharmacy.

The Central Council for Research in Homoeopathy (CCRH), New Delhi, an autonomous body of Department of AYUSH, Ministry of Health & Family Welfare, Govt. of India intends to engage the following categories of personnel. The persons selected will be liable for posting in its peripherals Institutes/Units located through out the country. The engagement will be purely on contract basis and selection will be made through Walk-in-Interview:

Our Client is a reputed MNC requires freshers (B.Sc/B.Pharma/D.Pharma) as Medical Representatives for Chennai H.Q.

Post: Medical Representative

A leading top mnc pharma " requires “experienced medical representatives only” to launch their division in south region ( tamilnadu, karnataka, kerala, & andhrapradesh) at every district wise. male graduate in any discipline preferably in science. one must be dynamic,challenging & skillful, and age must not cross 26 years. candidates must have good communication skills in english & in their local regional language . candidates must show original documents at the time of interview.