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Thermogravimetry

About Authors:
Jatin  Patel*
Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
*Patelj313@yahoo.com

ABSTRACT:
Thermogravimetry
is a branch of physical chemistry, materials research, and thermal analysis. It is based on continuous recording of mass changes of a sample of material, as a function of a combination of temperature with time, and additionally of pressure and gas composition.

It includes different types of Thermogravimetric analysis. In this article types, Instrumentation, Procedure, Application are priscribed.

Application are invited from Ph.D/M.Pharm/M.Sc for RA/PDF; Project Fellow; Technical Assistant; Field Assistant in National Center for Natural Resources - 26 posts

Pt. Ravishankar Shukla University is Chhattisgarh's largest and oldest institution of higher education, founded in 1964, and named after the first chief minister of erstwhile Madhya Pradesh. The University has a sprawling campus in the western part of the capital of Chhattisgarh, Raipur. The campus of University is spread in 207 acres of land. There are Twenty-Nine teaching departments in the University. Out of which six departments buildings have been constructed recently.

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The National Centre for Cell Science (NCCS) took birth as National Tissue Culture Facility in March 11, 1986 with a mandate of basic research, teaching & training, and as a national repository for cell lines/hybridomas etc. The centre is located in the midst of academically enriched environment of University of Pune campus, Pune.

STABILITY-INDICATING RP- HPLC METHOD FOR ANALYSIS OF SITAGLIPTIN IN THE BULK DRUG AND IT’S PHARMACEUTICAL DOSAGE FORM

About Authors:
V.DEEPTHI *, POORNIMA.Y, DR.G.DEVALA RAO, T.SANDEEP REDDY
Department of Pharmaceutical Analysis,
K.V.S.R.Siddharthacollege of pharmaceutical sciences,
Vijayawada-520010, India.
*deepthi759@gmail.com

ABSTRACT
A novel stability-indicating RP-HPLC method has been develop and validated for quantitative analysis of Sitagliptin in the bulk drug and in its pharmaceutical dosage forms using Hypersil–BDS- C18 column (250x4.6mmi.d, 5µ particle size) with 10mM Phosphate buffer (PH-3.5): ACN 60:40%v/v as isocratic mobile phase enabled separation of the drug from its degradation products. UV detection was performed at 260 nm. The method was validated for linearity, accuracy (recovery), precision, sensitivity, ruggedness and robustness. The linearity of the method was excellent over the range 10–60μg/ml (correlation coefficient 0.999). The limits of detection and quantification were 0.21 and 0.640μg/ml, respectively. Recovery of Sitagliptinfrom the pharmaceutical dosage form ranged from 99.99 to 100.05%.

Sitagliptin was subjected to stress conditions (Hydrolysis (acid, base), oxidation,thermal and photo degradation) and the stressed samples were analysed by use of the method. Degradation was observed in acid, base, and 30% H2O2. The drug was stable under the other stress conditions investigated. The degradation products were well resolved from main peak. The forced degradation studies prove the stability indicating power of the method.

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To trace the history of Jadavpur University is to trace a part of India’s freedom movement, at least from the Swadeshi Movement onwards. It was 1905 -1906. Bengal stood divided. The times were feverish.
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PYRROLE, FURAN, THIOPHENE DERIVATIVES & PHARMACOLOGICAL ACTIVITIES: A REVIEW

About Authors:
C.P.Meher*, S.P.Sethy, M.Madhavi
*Asst. Professor
Maheshwara Institute of  Pharmacy,
Chitkul, Patancheru, Medak, A.P
*chaitanyameher84@gmail.com

ABSTRACT:
Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs).Very important part of above is the heterocyclic-chemistry. Now a days so many investigation are carried out for developing new chemical entities having suitability for human life. A lot of research work is going on presently for development of new heterocyclic derivatives.The present review article is concern with the three, five-membered heterocyclic compound pyrrole, furan & thiophene  derivatives that show diverse pharmacological activities.

PHYSICAL STABILITY TESTING OF DRUGS AND DRUG PRODUCTS

About Authors:
L.D.Budania
Seth G. L. Bihani S. D. College Of Technical Education,
Institute Of Pharmaceutical Sciences & Drug Research, Gaganpath,
Sri Ganganagar, Rajasthan 335001
*ldbudania@gmail.com

ABSTRACT:
Stability is an essential quality attribute for drug products. If there is any functionally relevant quality attribute of a drug product that changes with time, this evaluation checked by pharmaceutical scientist and regulators who quantify drug product stability and shelf life. The rate at which drug products degrade varies dramatically. E.g. radiopharmaceutical products. Since the evaluation of the stability of drug is highly specialized and esoteric nature. Drug stability concerns about drug product safety, efficacy, and quality, found it to appropriate. Stability studies are done through the regulatory agencies such as FDA and HPB (health protection branch).

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EFFECT OF PRUNUS AMYGDALUS (BATSCH) IN DIFFERENT MODELS OF ULCER

About Authors:
Devendra Kumar1,Pragya Seth2
Department of Pharmaceutical technology,
1Sri Satya Sai collage of Pharmacy Bhopal,
2Lakshmi Narain College of Pharmacy, Bhopal
*guptadevendra15@gmail.com

Abstract
The present work describes the effect of methanolic extract of Prunus amygdalus (batsch.) on pylorus ligation and Ethanol-induced gastric ulcer models in Wistar rats. The present study provides a strong evidence of antiulcer activity of Prunus amygdalus extract against gastric lesions. The antiulcer activity is recognized by a reduction in acid-secretary parameters like total and free acidity, gastric volume and ulcer score suggesting that acid inhibition accelerates ulcer healing, thereby strengthening of mucosal barrier. In this present study it shows significant protection for Hexosamine in all treated groups in comparison to negative control group. Inthe LPO results it was observed that there was significance level difference in negative control group and all other group that indicates that lipid peroxides enzyme was higher in vehicle treated group. Ulcer score was determined by the counting of spots and severity of damage in stomach part by any moiety such as ethanol. Single drug treatment (200 mg/kg and 400mg/kg of P.A.E.) was effective up to a significant level (P<0.05) in compare to negative control group.Volume of gastric juice indicate the secretions of gastric fluid and it is higher in negative control group and all drug treated group was effective in relation to negative control group in significance level (P <0.05).

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INDIAN CITATION INDEX: A NEW WEB PLATFORM IN THE CHEMICAL AND PHARMACEUTICAL SCIENCES

About Authors:
LaxmiChand  Sharma*, Deepak Kumar Jha
*Information Analyst- Chemical & Pharmaceutical Section
Knowledge Foundation Society (DIVAEnterprises), B -9 NarainaVihar, New Delhi-110028
*laxchandsharma@gmail.com

Abstract:
The development of Indian citation index (ICI) is necessary for chemical, pharmaceutical and life sciences. On the basic of ICI our country provide the realistic image in the world. For getting more details related to the journal’s citations there is more searching facilities such as search types of quick search, advanced search, cited reference search and subject scope and competition search. It is provide awareness about the Indian citation index, a new web platform and their type searches for knowledge professionals and information professionals who indulged in chemical and pharmaceutical information searching.

NANOTECHNOLOGY IN MEDICINE

About Authors:
P.Ramanujaiah*, Dr M.Purushothaman, Hemalatha
Vasavi institute of pharmaceutical sciences, Kadapa
*rama.mpharm@gmail.com

Abstract:
The application of nanotechnology to drug delivery has currently more than 20 Nanoparticles therapeutics are in clinical use, validating the ability of Nanoparticles to improve the therapeutic index of drugs. In addition to the already approved Nanoparticles, numerous other Nanoparticles platforms are currently under various stages of preclinical and clinical development, including various liposomes, polymeric micelles, dendrimers, quantum dots, gold Nanoparticles, and ceramic Nanoparticles. With continued research and development efforts, nanotechnology is expected to have a tremendous impact on medicine for decades to come.

ROLE OF CHROMATOGRAPHY IN EVALUATION OF HERBAL DRUGS: A SHORT REVIEW

About Author:
Alimuddin Saifi
N.K.B.R. College of Pharmacy & Research Centre,
Meerut
asaifi2005@gmail.com

Abstract
Herbal drugs are accepted as important therapeutic agents for the treatment of many diseases. The development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Pharmacognostical analysis of medicinal herbs remain challenging issues for analytical chemists, as herbs are a complicated system of mixtures. Analytical separation techniques for example high performance liquid chromatography (HPLC), gas chromatography (GC) and mass spectrometry (MS), High Performance Thin Layer Chromatography (HPTLC) etc. among the most popular methods of choice used for quality control of raw material and finished herbal product.

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