Cadila Pharmaceuticals Ltd., one of the largest Indian pharmaceutical companies has presence in 90 countries across the globe catering to over 45 therapeutic areas. The company has one of the best R&D setup in India which forms the backbone of our state-of-the-art manufacturing facilities in India and abroad, approved by various regulatory authorities including USFDA, MHRA (UK).

Candidates who possess the qualification mentioned below may attend the WALK IN INTERVIEW on 05.12.2011 between 9.00 AM to 12.00 PM with all original certificates, including community certificate and recent passport size photograph. The selected candidates will be working under the DBT project entitled “Characterization of the bacterial toxins isolated from soil samples for the control of mosquito vectors”.

Health biotech is a company that promises good health for all by providing quality medicines at affordable prices and committed to care the people for keeping good health. Health Biotech has won many accolades in the domestic and international pharmaceutical domain.

About Authors:
Kataria Sahil,Middha Akanksha, Sandhu Premjeet
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA

ABSTRACT
Method validation is the process used to confirm that the analytical procedure employed for a specific test is suitable for its intended use. Results from method validation can be used to judge the quality, reliability, and consistency of analytical results; it is an integral part of any good analytical practice. When extended to an analytical procedure, depending upon the application, it means that a method works reproducibly, when carried out by same or different persons, in same or different laboratories, using different  reagents,  different  equipment etc.  In  this  review  article  we  discussed  about  the  strategy  and  importance  of  validation  of  analytical  methods.

About Authors:
D.Ramadevi and S.Ganapaty*
Department of Pharmacognosy and Phytochemistry,
College of Pharmaceutical Sciences, Andhra University,
Visakhapatnam -530 003, India

Abstract
The fusidic acid(ent-16α-acetoxy-3β-dihydroxy-4β,8β,14α-trimethyl-18-nor-5β,10α-cholesta-(17z)-17(20),24-dien-21-oic acid) together with known compounds β-sitosterol, 2-methylanthraquinone, scopoletin, betulinic acid, corchoroside –A and cannogenol  from  the root extract of Corchorus olitorius. Out of these compounds, 2 - methyl anthraquinone and fusidic acids were new to the genus Corchorus and reported for the first time from C.olitorius. The triterpenoid antibiotic fusidic acid was  obtained earlier from a fungi (Fusidium coccineum) , is now reported from the plant C.olitorius.  Occurance  of coumarins in Corchorus genus are rare, but the author could isolate scopoletin, a coumarin from this species.

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India.

IIP is located on 6 acres of land at village Sadavali, about 3 Kms from Devrukh city. The campus includes Administrative area, Instructional Area, Laboratories, Library and Residential buildings etc. in an area admeasuring 5000 Sq.Mtrs. This Institution is a fully developed residential Pharmacy Institute. At present there are over 100 students studying in the Institute.

Established in 1978, "Cachet Pharmaceuticals Pvt. Ltd" is engaged in the manufacturing and marketing of finished pharmaceutical formulations & nutraceuticals in, INDIA and Overseas. The group company ranks among the top 5 pharmaceutical companies in the Indian Pharmaceutical Industry.

Institute of Genomics & Integrative Biology (IGIB), one of the premier constituent establishments of Council of Scientific and Industrial Research (CSIR), is carrying out research and development in the areas of genomics, molecular medicines, bioinformatics and environmental biotechnology. The Institute has played pivotal role in genomics and integrative biology through R & D partnerships and in collaboration with medical institutes, universities and the industry.

Tech Mahindra is part of the US $7.1 billion Mahindra Group, in partnership with British Telecommunications plc (BT), the world’s leading communications service provider. Focused primarily on the telecommunications industry, Tech Mahindra is a leading global systems integrator and business transformation consulting organization.

ANSWERS of Previous PharmaQUIZ-11:

1.D    2.D    3.B    4.D    5.A

6.C    7.A    8.B    9.D    10.C

About Authors:
Dr. A. K. Pathak, Parul Sengar, Kamlesh Kumar*
Department of Pharmacy, Barkatullah University
Bhopal, M. P.

Abstract
A Quantitative Structure Activity Relationship study on a Series of 40 molecules of (4-Quinolylhydrazone compounds) with anti-tubercular activity analogues was made using combination of various physicochemical descriptors (Thermodynamic, electronic and spatial). Several statistical expressions for 2D QSAR & 3D QSAR were developed using stepwise partial least square (PLS) regression analysis and K-Nearest neighboring molecular field analysis (K-NNMFA) respectively. The studies on 2D-QSAR, suggested the four descriptors T_C_C_2, T_C_N_4, Surface area excluding P & S, SsCH3E-index, and H donor count were common and highly contributed the activity. 2DQSAR model developed using partial least square regression approach. Negative logarithmic value of (MIC) was taken as dependent variable and selected discriptors were taken as independent varable. The analysis resulted in the following 2D-equation suggest that, MIC50 = [+0.1587 T_C_C_2- 0.0593 SsCH3E-index- 0.1395 T_C_N_4+ 0.3888 H-Donor Count -3.1556], n =26; Degree of freedom = 22; r² = 0.75; q² = 0.67; F test = 22.63;  r² se = 0.20 ; q² se = 0.23; pred_r² = 0.46 ; pred_r² se = 0.24, a H-donor group at Ar, is important for guiding the design of a new molecule. 3DQSAR model developed using K-nearest neighbour method (training set =33 and test set = 7). The best model derived by the method have q2 = 0.51, q2_se = 0.25, Predr2 = 0.71, pred_r2se = 0.16, n=33, k Nearest Neighbor is 2, Degree of freedom =28. The steric and electrostatic descriptors at the grid points, E_916 (0.1865, 0.3006); S_591 (-0.2851, -0.2580); S_1027 (-0.3273, -0.3090); S926 (30.000, 30.000) plays important role for design of new molecule. 3DQSAR analysis of series of 4-Quinolylhydrazone compounds informed that electropositive and less bulky group increases the biological activity.

ANSWERS of Previous PharmaQUIZ-10:

1.D    2.A    3.C    4.A    5.A

North-Eastern Hill University was set up by an Act of Parliament and notified on 19th July 1973.

NATIONAL BRAIN RESEARCH CENTRE (NBRC), Manesar-122 050, Gurgaon, requires a Junior Research Fellow in the project funded by Department of Biotechnology, Govt of India

The Regional Medical Research Centre for Tribals(RMRCT) at Jabalpur  was established in 1984, under the aegisof the Indian Council of Medical research(ICMR), New Delhi, which is an autonomous body under  the Department of Health Research, Ministry of Health and family Welfare, Government of India, New Delhi. The centre is planning, executing and monitoring the regional health problems of the tribal, in and around central India. Training is being imparted to local expertise for communicable diseases.

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

About Authors:
Dr.Vivek Srivastav (Ph.D)
Maxcure drugs & Pharmaceuticals Ltd.
B-7, Laxmi Tower-II, Block-C, L.S.C.
Saraswati Vihar, Delhi-110034

Gout is a kind of arthritis that occurs when uric acid builds up in the joints. Acute gout is a painful condition that typically affects one joint. Chronic gout is repeated episodes of pain and inflammation, which may involve more than one joint. Gout is a medical condition usually characterized by recurrent attacks of acute inflammatory arthritis—a red, tender, hot, swollen joint. The metatarsal-phalangeal joint at the base of the big toe is affected most often (condition also known as podagra¹), accounting for half of cases. Other joints, such as the heels, knees, wrists and fingers, may also be affected. Joint pain usually begins over 2–4 hours and during the night. The reason for onset at night is due to the lower body temperature then. Other symptoms that may occur along with the joint pain include fatigue and a high fever

About Author:
Anuradha Kaplish
M. Pharmacy (Drug discovery and drug development)
University Institute of Pharmaceutical Sciences, Panjab University,
Chandigarh-160014, India

1. INTRODUCTION
A peptic ulcer is a hole in the gut lining of the stomach, duodenum, or esophagus. A peptic ulcer of the stomach is called a gastric ulcer; of the duodenum, a duodenal ulcer; and of the esophagus, an esophageal ulcer. An ulcer occurs when the lining of these organs is corroded by the acidic digestive juices which are secreted by the stomach cells. Peptic ulcer disease is common, affecting millions of Americans yearly. The medical cost of treating peptic ulcer and its complications runs in the billions of dollars annually. Recent medical advances have increased our understanding of ulcer formation [1,2].