Institute of Genomics & Integrative Biology (IGIB), one of the premier constituent establishments of Council of Scientific and Industrial Research (CSIR), is carrying out research and development in the areas of genomics, molecular medicines, bioinformatics and environmental biotechnology. The Institute has played pivotal role in genomics and integrative biology through R & D partnerships and in collaboration with medical institutes, universities and the industry.

Tech Mahindra is part of the US $7.1 billion Mahindra Group, in partnership with British Telecommunications plc (BT), the world’s leading communications service provider. Focused primarily on the telecommunications industry, Tech Mahindra is a leading global systems integrator and business transformation consulting organization.

ANSWERS of Previous PharmaQUIZ-11:

1.D    2.D    3.B    4.D    5.A

6.C    7.A    8.B    9.D    10.C

About Authors:
Dr. A. K. Pathak, Parul Sengar, Kamlesh Kumar*
Department of Pharmacy, Barkatullah University
Bhopal, M. P.

Abstract
A Quantitative Structure Activity Relationship study on a Series of 40 molecules of (4-Quinolylhydrazone compounds) with anti-tubercular activity analogues was made using combination of various physicochemical descriptors (Thermodynamic, electronic and spatial). Several statistical expressions for 2D QSAR & 3D QSAR were developed using stepwise partial least square (PLS) regression analysis and K-Nearest neighboring molecular field analysis (K-NNMFA) respectively. The studies on 2D-QSAR, suggested the four descriptors T_C_C_2, T_C_N_4, Surface area excluding P & S, SsCH3E-index, and H donor count were common and highly contributed the activity. 2DQSAR model developed using partial least square regression approach. Negative logarithmic value of (MIC) was taken as dependent variable and selected discriptors were taken as independent varable. The analysis resulted in the following 2D-equation suggest that, MIC50 = [+0.1587 T_C_C_2- 0.0593 SsCH3E-index- 0.1395 T_C_N_4+ 0.3888 H-Donor Count -3.1556], n =26; Degree of freedom = 22; r² = 0.75; q² = 0.67; F test = 22.63;  r² se = 0.20 ; q² se = 0.23; pred_r² = 0.46 ; pred_r² se = 0.24, a H-donor group at Ar, is important for guiding the design of a new molecule. 3DQSAR model developed using K-nearest neighbour method (training set =33 and test set = 7). The best model derived by the method have q2 = 0.51, q2_se = 0.25, Predr2 = 0.71, pred_r2se = 0.16, n=33, k Nearest Neighbor is 2, Degree of freedom =28. The steric and electrostatic descriptors at the grid points, E_916 (0.1865, 0.3006); S_591 (-0.2851, -0.2580); S_1027 (-0.3273, -0.3090); S926 (30.000, 30.000) plays important role for design of new molecule. 3DQSAR analysis of series of 4-Quinolylhydrazone compounds informed that electropositive and less bulky group increases the biological activity.

ANSWERS of Previous PharmaQUIZ-10:

1.D    2.A    3.C    4.A    5.A

North-Eastern Hill University was set up by an Act of Parliament and notified on 19th July 1973.

NATIONAL BRAIN RESEARCH CENTRE (NBRC), Manesar-122 050, Gurgaon, requires a Junior Research Fellow in the project funded by Department of Biotechnology, Govt of India

The Regional Medical Research Centre for Tribals(RMRCT) at Jabalpur  was established in 1984, under the aegisof the Indian Council of Medical research(ICMR), New Delhi, which is an autonomous body under  the Department of Health Research, Ministry of Health and family Welfare, Government of India, New Delhi. The centre is planning, executing and monitoring the regional health problems of the tribal, in and around central India. Training is being imparted to local expertise for communicable diseases.

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

About Authors:
Dr.Vivek Srivastav (Ph.D)
Maxcure drugs & Pharmaceuticals Ltd.
B-7, Laxmi Tower-II, Block-C, L.S.C.
Saraswati Vihar, Delhi-110034

Gout is a kind of arthritis that occurs when uric acid builds up in the joints. Acute gout is a painful condition that typically affects one joint. Chronic gout is repeated episodes of pain and inflammation, which may involve more than one joint. Gout is a medical condition usually characterized by recurrent attacks of acute inflammatory arthritis—a red, tender, hot, swollen joint. The metatarsal-phalangeal joint at the base of the big toe is affected most often (condition also known as podagra¹), accounting for half of cases. Other joints, such as the heels, knees, wrists and fingers, may also be affected. Joint pain usually begins over 2–4 hours and during the night. The reason for onset at night is due to the lower body temperature then. Other symptoms that may occur along with the joint pain include fatigue and a high fever

About Author:
Anuradha Kaplish
M. Pharmacy (Drug discovery and drug development)
University Institute of Pharmaceutical Sciences, Panjab University,
Chandigarh-160014, India

1. INTRODUCTION
A peptic ulcer is a hole in the gut lining of the stomach, duodenum, or esophagus. A peptic ulcer of the stomach is called a gastric ulcer; of the duodenum, a duodenal ulcer; and of the esophagus, an esophageal ulcer. An ulcer occurs when the lining of these organs is corroded by the acidic digestive juices which are secreted by the stomach cells. Peptic ulcer disease is common, affecting millions of Americans yearly. The medical cost of treating peptic ulcer and its complications runs in the billions of dollars annually. Recent medical advances have increased our understanding of ulcer formation [1,2].

About Authors:
Honey Jain, Neha Batra
School of Pharmaceutical Sciences,
Jaipur National University,
Jaipur

ABSTRACT
The family Cyperacea includes approximately 3000 species of which about 220 species are identified as weeds and of which 42% of these weeds are in the genus Cyperus. Both purple nutsedge (Cyperus rotundus L.) and yellow nutsedge (C. esculentus L.) are problem weeds in many parts of the world. Nutsedges originate from tropical and subtropical areas. . The plant produces rhizomes, tubers, basal bulbs and fibrous roots below ground, and rosettes of leaves, scapes, and umbels above ground.  C. rotutdus consists of rhizome and stolon having a number of wiry roots, stolon 10-20 cm long having a number of rhizomes, crowded together on the stolons, rhizomes bluntly conical and vary in size and thickness.The rhizomes are initially white and fleshy with scaly leaves and then become fibrous, wiry, and very dark brown with age. Purple nutsedge is readily distinguished from yellow nut sedge and other sedges by its purplish brown spikelets and scaly or wiry rhizomes that often bear chains of tubers.Phytochemical studies have shown that the major chemical components of this herb are polyphenol, flavonol glycoside, alkaloid, saponins, sesquiterpenoids and essential oil. Rhizome of the plant is used in fever,arthritis,diuretic, nervine tonic, treatment of diarrhea and dysentery ,leprosy, bronchitis, amenorrhea, and blood disorders. Leaves and seeds are rich in volatile oil and act on digestive system. Fruits are used as carminative , diuretic tonic, stomachic. Oil is fungicidal and bactericidal.

The Institute of Microbial Technology (IMTECH) is a constituent R&D establishment of the Council of Scientific and Industrial Research (CSIR). Applications for Scientific positions for following positions are invited by the institute, which is engaged in research in many different areas of modern biological sciences and microbe-related biotechnology, with special emphasis on research and development of an interdisciplinary nature :

The Institute of Bioresources and Sustainable Development (IBSD) is one of the autonomous institutes under the Department of Biotechnology (DBT), Ministry of Science & Technology, Govt. of India. The objective of IBSD is to develop and utilize the rich bioresources of the Northeastern Region of the country through the application of modern tools of biology and biotechnology.

Exotic Naturals is a Natural Products R&D company. We develop novel plant products for use in human healthcare and crop health. Since it was founded in 1994, Exotic Naturals has served the needs of the Dietary Ingredients, Herbal Supplements, Phytopharmaceutical and Biopesticide industry in N. America, Europe and Asia-Pacific.

ANSWERS of Previous PharmaQUIZ-9:
1.C    2.C    3.C    4.B    5.B
6.C    7.B    8.B    9.A    10.D

ANSWERS of Previous PharmaQUIZ-8:

1.A    2.B    3.A    4.D    5.B

Cipla known for its innovative pharmaceutical products backed by latest in technology and creative marketing practices, is enjoying a commanding position among the top pharma companies in the country.
Several specialised therapeutic divisions and promising new products have been launched and many more are in the pipeline.