Hindustan Aeronautics Ltd. (HAL), a Navratna Central Public Sector Undertaking, is a premier Aeronautical Company of South East Asia with 20 Production / Overhaul / Service Divisions and 10 co-located R&D Centres spread across the country.

About Authors:
Sandhu Premjeet¹, 2,Rathore Devashish², Kataria Sahil¹ , Middha Akanksh^1
1Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
² School of Pharmaceutical Sciences, RGPV University campus,
Bhopal, M.P, INDIA

ABSTRACT
The blood – brain barrier (BBB) has always presented a challenge to scientists for brain drug targeting . the BBB evolved in such a way that it protects the brain from various foreign substance such as neurotoxins. This mechanism makes the BBB an insurmountable . This mechanism makes BBB an insurmountable barrier for numerous highly essential drugs , including antibiotics, cytostatics and other CNS active drug Drugs may be administered directly into the CNS or administered systematically (e.g. by intravenous injection) for targeted action in the CNS. The major challenge to CNS drug delivery is the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. Various strategies that have been used for manipulating the blood-brain barrier for drug delivery to the brain include osmotic and chemical opening of the blood-brain barrier as well as the use of transport/carrier systems. Other strategies for drug delivery to the brain involve bypassing the BBB. Various pharmacological agents have been used to open the BBB and direct invasive methods can introduce therapeutic agents into the brain substance. It is important to consider not only the net delivery of the agent to the CNS, but also the ability of the agent to access the relevant target site within the CNS. Various routes of administration as well as conjugations of drugs, e.g. with liposomes and nanoparticles are considered. Some routes of direct administration to the brain are non-invasive such as transnasal route whereas others involve entry into the CNS by devices and needles such as in case of intrathecal and intracerebroventricular delivery.

About Authors:
Anil kumar
Jubilant chemsys Limited, Noida-201301
Babu Banarsi Das National Institute of Technology and Management
Akhilash Das Nagar, Lucknow

Abstract
Presence of moisture influences chemical stability, crystal structure, powder flow, compaction lubricity, dissolution rate, and polymer film permeability in solid dosage forms and lead to growth of microorganisms, change in thixotropy in semi-solid dosage forms. Moreover, unit operations obviously depending on the amount and state of water present are also influenced by it. Therefore, moisture influences the properties of individual active ingredients and excipients, and it is essential to characterize the effect of moisture on these individual components. This article lay emphasis on determination of moisture by various methods and illustrates the changes induced by moisture on several product and process attributes

ANSWERS of Previous PharmaQUIZ-25:

1.A    2.C    3.C    4.B    5.B

6.C    7.C    8.D    9.C    10.A

The All India Institute of Ayuveda, Sarita Vihar, New Delhi, is a newly established Institute for undertaking multi-disciplinary research and teaching in related subjects for standardization, quality control and scientific validation of Ayurveda drugs and therapies.
The Institute is headed by a Director, the post of which carries the pay scale of Rs.37400-67000- NPA (PB- 4 Grade Pay Rs. 12000) plus allowances like H.R.A., T.A. etc as admissible.

About Authors:
Kaushal Chovatiya, D.R. Mundhada
Agnihotri College of Pharmacy, Wardha,
Maharashtra, India.

Abstract:
Cancer is the second leading cause of death worldwide. Conventional cancer therapies cause serious side effects and, at best, merely extend the patient’s lifespan by a few years. Cancer control may therefore benefit from the potential that resides in alternative therapies. The demand to utilize alternative concepts or approaches to the treatment of cancer is therefore escalating. There is compelling evidence from epidemiological and experimental studies that highlight the importance of compounds derived from plants “phytochemicals” to reduce the risk of colon cancer and inhibit the development and spread of tumors in experimental animals. More than 25% of drugs used during the last 20 years are directly derived from plants, while the other 25% are chemically altered natural products. Still, only 5-15% of the approximately 250,000 higher plants have ever been investigated for bioactive compounds. The advantage of using such compounds for cancer treatment is their relatively non-toxic nature and availability in an ingestive form. An ideal phytochemical is one that possesses anti-tumor properties with minimal toxicity and has a defined mechanism of action. As compounds that target specific signaling pathways are identified, researchers can envisage novel therapeutic approaches as well as a better understanding of the pathways involved in disease progression. Plant derived compounds have played an important role in the development of several clinically useful anticancer agents. Several anticancer agents including taxol, vinblastine, vincristine and topotecan are in clinical use all over the world. A number of promising agents such as combrestatin, betulinic acid and silvesterol are in clinical or preclinical development.An attempt has been made to review some medicinal plants used for the prevention and treatment of cancer and recent state of development of anticancer drugs regarding Natural Products.

It is a dynamic, fast growing, ethical, systematic & marketing oriented co. with a vision of becoming a force to reckon within the pharmaceutical industry & known for its successful introduction of innovative concepts/products in various segments.

ANSWERS of Previous PharmaQUIZ-24:

1.B    2.A    3.B    4.D    5.B

6.B    7.C    8.C    9.D    10.B

MIOT Hospitals, A leading Multi-Speciality Hospital in India known for its adoption of Professional standards, both Nationally and Internationally.
Being the leading centre for Orthopaedics and Orthopaedic Research, MIOT Hospitals has the World Class Specialties in the field of Joint Replacement Surgeries, Orthopaedics and Trauma Care. MIOT also has specialized centre for Nephrology, Thoracic & Cardio Vascular Care, Neurology and Neuro Surgery, Paediatric Cardio Surgery and many other specialties.

One of the fastest Growing Company that will have its presence on PAN India basis within 2years, currently having its operations in Northern and Western part of India.We believe in providing best working environment to our employees and help you succeed in your personal and professional Life. We are rapidly growing pharmaceutical company and only needs people with right attitude.

ANSWERS of Previous PharmaQUIZ-23:

1.A    2.D    3.D    4.C    5.B

6.A    7.C    8.D    9.D    10.B

Panacea Biotec is a leading research based Health Management Company, with an annual turnover of approx. Rs. 830 Crores. We are engaged in research, development, manufacture & marketing of Vaccines, Bio-Pharmaceuticals and Pharmaceuticals (Rx & OTC) of international quality and Health Services. All Panacea Biotec plants are accredited by international agencies and they follow current Good Manufacturing Practices, as per WHO guidelines.We offer stimulating work environment & a career that spells growth.

Application are invited from eligible candidates for the selection of a suitable candidate on deputation/short term/contract for a period of 5 years or upto the date of retirement of the incumbent, whichever is earlier, for the post of Director in National Institute of Unani Medicine(NIUM), Bangalore an autonomous organization under the administrative control of the Department of AYUSH, Ministry of Health and Family Welfare, New Delhi in the Pay Scale of Rs.37400-67,000 with Grade Pay of Rs.10000 + NPA and other usual a

ANSWERS of Previous PharmaQUIZ-22:

1.B    2.B    3.A    4.B    5.C

6.C    7.A    8.C    9.C    10.B

The Graduate Pharmacy Aptitude Test (GPAT 2012) would be conducted under the aegis of National Monitoring Committee, All India Council for Technical Education, New Delhi by The Maharaja Sayajirao University of Baroda, Vadodara, as per AICTE guidelines.

ANSWERS of Previous PharmaQUIZ-21:

1.C    2.A    3.B    4.D    5.B

6.C    7.C    8.D    9.B    10.B

The setting up of a separate Department of Biotechnology (DBT), under the Ministry of Science and Technology in 1986 gave a new impetus to the development of the field of modern biology and biotechnology in India. In more than a decade of its existence, the department has promoted and accelerated the pace of development of biotechnology in the country. Through several R&D projects, demonstrations and creation of infrastructural facilities a clear visible impact of this field has been seen.