CSIR-Central Drug Research Institute, Lucknow is a premier R&D Institute under the aegis of the Council of Scientific and Industrial Research (CSIR), New Delhi which is an autonomous body under Department of Scientific and Industrial Research, Government of India.

1942 saw nationalistic fervor reaching new peaks as the nation struggled for Independence. It was about the same time that a young man, Mr. Amratlal, struggled to face the might of the pharmaceutical multinationals. Through his untiring efforts was born the Bombay Tablet Company.

About Authors:
Jenish.R*, M.Senthil kumar, Dinesh, Ahokkumar, Marshel, Hariharan
Annai veilankanni’s college of pharmacy
Saidapet, Chennai-600015
Tamilnadu
*jenishnathan@gmail.com

ABSTRACT
Alfuzosin is a non-subtype specific alpha(1)-adrenergic blocking agent that exhibits selectivity for alpha(1)-adrenergic receptors in the lower urinary tract. Inhibition of these adrenoreceptors leads to the relaxation of smooth muscle in the bladder neck and prostate, resulting in the improvement in urine flow and a reduction in symptoms in benign prostate hyperplasia. Alfuzosin also inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. The alfuzosin of the present investigation is designed to retain in the stomach and deliver the drug alfuzosin for longer periods of time. The developed floating provides increased absorption of the alfuzosin at a rate such that effective plasma levels can be achieved and maintained for a prolonged duration. Formulations 6 displayed drug release considered in 0.1N HCL and Formulation 6 shows better drug release in dissolution profile.

About Authors:
A.Tamil Selvan*, R.Suresh¹, D.Benito Johnson², R.Suresh Kumar³, R.Venkatanarayanan⁴, L.Sivakumar⁵
Department of Pharmacology
Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad – 97
1-4RVS College of Pharmaceutical Sciences, Sulur, Coimbatore- 641402
⁵SKM Siddha and Ayurvedha Company (India) Limited, Erode - 638104.
*tamilselvanpharmacologist@gmail.com

ABSTRACT
In this study, polyherbal extract of Cycas circinalis, Nardostachys jatamansi and Artemisia absinthium ethanolic fraction was explored for its antidepressant property using Forced swim test (FST) and Tail suspension test (TST). Many of its individual constituents have been used for central nervous system (CNS) activities but no systematic work was carried on this combination. In this study its effect on depression was explored in rats. For this purpose the plants part were extracted by successive solvent extraction by Soxhylation. Ethanolic extract was chosen for the pharmacological evaluation, based upon the phytochemical and instrumental analysis. The ethanolic extract was subjected to FT-IR analysis for finding the possible number and nature of function groups present in it. Also the extract was analysed by HPLC for the number possible phytocompounds/phytoconstituents present, which may directly or indirectly involve in the brain neurochemical activity. Acute and Subacute toxicity study revealed the dose upto 2000mg/kg the extract had not toxic symptoms and no mortality. The therapeutic dose was found to be 200mg/kg and there was no toxic damage to liver and kidney observed in subacute toxicity study. The ethanolic extract of the polyherbal combination exhibited significant (P<0.001) antidepressant activity  as indicated by its ability to decrease swim stress and tail suspension induced immobility time in rats as compared with that standard Fluoxetine. As well as restoring biogenic amines to normal level that was altered by the swim stress and tail suspension test in whole rat brain assay by HPTLC method. The result indicates this polyherbal combination can be a potential candidate for .managing depression. However further studies are required to confirm the exact therapeutic efficacy.

Walk-in-Interview for filling of the following catagories of the Contractual Post under ZSS of Dhenkanal District.

Post: MPHW(M)

Ordnance Factory Ambajhari, Nagpur is a premier factory in the family of 40 Ordnance Factories. Its corporate office is ORDNANCE FACTORY BOARD located at KOLKATA. The factory is engaged in the manufacture of Ammunition Hardware viz Shells,Cartridge cases,Fuzes & Primers,Castings & Extrusion of Special Al. Alloys and Fabrication of Floating & Mannually Launched Assult Bridges.

Intra Labs is involved in the manufacturing and marketing of Pharameceutical Formulations - Therapeutic and Prophylactic since 1981. We have GMP accredited and manufacturing facility specialities patented in accordance with WHO norms. Our Company has a wide range of Marketing Network throughout the country to cadre with easy accessibility to our clients.

The JNU campus is a microcosm of the Indian nation, drawing students from every nook and corner of the country and from every group and stratum of society.

Applications are invited on the prescribed application form for admission to the Ph.D Programme in the following disciplines

Engineering, Management, Computer Applications, Mathematics, Home Science, Mass Communication, Chemistry, Pharmacy, Library Science

Post: Pharmacist on Contractual basis

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology, Government of India.

About Authors:
Kalpesh Ashara
Registered Pharmacist S.K.R.I.Medicines Centre, Rajkot, Gujarat, India,
M.Pharm Semester-I Student of B.K.Mody Govt.Pharmacy College Rajkot,
Department of Pharmaceutics GTU, Gujarat, India.
kalpeshashara@yahoo.com, kalpeshshr5@gmail.com*

Abstract:
Spectrophotometry is an attractive method for PKa determination in very diluted aqueous solution about 10^-5 to 10^-6M provided that the compound possesses P^H dependent light absorption due to the presence of a chromospheres in proximity to the ionization centers. Traditionally 6 to 8 aliquot solutions of samples in identical concentrations but with different P^H values are prepared & their absorption spectra are registered at single wavelength. This series of solutions can be generated by either preparing the sample in buffer solutions of known P^H or titrating the sample solution e.g. alkalimetry. Then half the absorbance of maximum plotted on graph & interpolated on x-axis that will give value of P^H is Pka  & negative Antilog of that value at base 10 give value of ka i.e. Dissociation Constant (Pka=-logka). This exercise is carrying out in below assignment.

Health Management and Research Institute (HMRI) is one of the leading non-profit organisations, working towards improved access and quality of healthcare services for all. For its operations in Pune, applications are invited for the following positions from suitable candidates.

Post: Health Advice Officer

Indira Institute of Pharmacy (IIP) is a Degree Pharmacy College established and run by Prabodhan Shikshan Prasarak Sanstha (PSPS). PSPS is a registered charitable trust established with a view to promoting education in the state. The trust is registered under the Bombay public trust act 1950 with the charity commissioner office at Ratnagiri. The college i.e. IIP is approved by AICTE & PCI, New Delhi, Recognized by Directorate of Tech. Education (DTE), Maharashtra and affiliated to University of Mumbai.

The Birla Institute of Technology & Science, BITS Pilani is an all-India Institute for higher education. The primary motive of BITS is to "train young men and women able and eager to create and put into action such ideas, methods, techniques and information". The Institute is a dream come true of its founder late Mr G.D.Birla - an eminent industrialist, a participant in Indian freedom struggle and a close associate of the Father of Indian Nation late Mr. Mohandas Karamchand Gandhi (Mahatma Gandhi).

Guru Gobind Singh Indraprastha University is a dynamic growth oriented organization established to facilitate and promote studies and research in emerging areas of higher education with focus on professional education. The University imparts education in the field of Engineering, Science, Technology, Humanities & Social Sciences etc. at Graduate, Post-Graduate, and Doctorate Level under its various Schools.

Birla Institute of Technology (Deemed University u/s 3 of UGC Act 1956) is one of the premier institutes imparting education and conducting research in the fields of Engineering, Management, Architecture and Pharmaceutical Sciences.