The origin of Banasthali is unique in more ways than one. Banasthali  owes its existence neither to the zeal of an educationist, nor to that of a social reformer. It is also not the creation of a Philanthropist's purse. It has arisen like the fabled phoenix from the ashes of a blossoming flower Shanta Bai that had withered before its bloom. It is a spontaneous filling up of the vacuum caused by Shantabai's death.It was on October 6, 1935 that Smt.

The Himalaya Drug Company was founded in 1930 by Mr. M. Manal with a clear vision to bring Ayurveda to society in a contemporary form and to unravel the mystery behind the 5,000 year old system of medicine. This included referring to ancient ayurvedic texts, selecting indigenous herbs and subjecting the formulations to modern pharmacological, toxicological and safety tests to create new drugs and therapies.

About Authors:
Kapil Sharma*, Priyanka sharma**
*Yaresun Pharmaceutical Pvt Ltd,India
**M.sc. Student, Rajasthan, India
*pharma_kapil@rediffmail.com

1. INTRODUCTION
The mammalian intestinal tract contains a complex and diverse society of both pathogenic and non pathogenic bacteria. Most research to date has focused on the mechanism by which pathogenic bacteria achieve their detrimental effect. However, more recent research has unveiled a glimpse into the mechanism of action and potential therapeutic role of indigenious non pathtogenic microorganisms (probiotic).
Probiotic, prebiotic, and synbiotic are moving from snake oil into the mainstream of medical therapy. This evolution has been facilitated by our ever increasing understanding of the mechanism of action of these agents and by the development of molecular method for analyzing and identifying complex bacterial community within the mammalian intestine.^{1, 2}

The University Institute of Pharmaceutical Sciences of the Panjab University is a premier institution of Pharmaceutical Education and Research in the country.

NIPER, Rae Bareli at ITI campus, Rae Bareli under the mentoring Institute of Central Drug Research Institute, Lucknow invites applications for engagement of following position on purely temporary basis on contract initially for a period of 1 year which can be extended further. The selected candidates shall have no claim for regularization against any regular post either in NIPER or CDRI.

The University Institute of Pharmaceutical Sciences of the Panjab University is a premier institution of Pharmaceutical Education and Research in the country.

Company is engaged in manufacturing and marketing of speciality and high quality pharmaceutical formulations and healthcare products.

Post: QC Chemist

“ELICO” The name which pioneered and gave new meaning and direction to the word Analytical Instrumentation in India and electronics in state of Andhra Pradesh, and this word “Electronics” has now become the identity of Hyderabad. The company commenced its operations in 1959 slightly more than a decade after Independence of Country. It was a time when there were very few players nationally in the technology arena and none locally.

Lyka Labs Limited is committed to creating a better tomorrow for India. Maintaining a core competency in Lyophilization, allows Lyka Labs to supply Freeze Dried Drugs in sufficient quantities with the right quality. Lyka strives to manage this business in an ethical and transparent manner.

Post: Production Executive

A State-of-the-Art manufacturing facilities and has a strong position in the Softgel industry. Company's primary focus has been customizing drug delivery solutions for the healthcare industry. They have world class manufacturing facilities which have been accredited by U.K. MHRA, Australian TGA, WHO GMP, Ministry of Health (UAE, Jordan, Kenya, Malaysia, Iran, SriLanka, Vietnam, Thailand etc.), NAFDAC Nigeria & others and a packaging facility in Dubai Free Trade Zone.

Pharmaceutical company producing a wide range of quality, affordable generic and branded formulations and APIs for the developed and developing markets of the world.

Post: MR/MT

About Authors:
Satinder Kumar
Manav Bharti University,
Solan (H.P)
skcrock87@yahoo.in

Abstract:-
Validation is the most recognized and important parameter of GMPs. This article provide introduction about the process validation of pharmaceutical manufacturing process and its importance according to The U.S. Food and Drug Administration (FDA). This work is to present an introduction and general overview on process validation of pharmaceutical manufacturing process. Quality cannot be ensured by sampling, testing, release of materials and products. Quality assurance techniques must be used to build the quality into the product at every step and not just tested for at the end. Process validation of a process will ensure production of drug of reproducible quality. In pharmaceutical industry, Process Validation performs this task to build the quality into the product because according to ISO 9000:2000, it had proven to be an important tool for quality management of pharmaceuticals.

A service oriented export trade company specialized into overseas distribution and manufacturing of pharmaceutical formulations, active pharmaceutical ingredients and related chemicals. Right since the inception of this company since 1985 we are involved in the same activity. With changing times, the pharmaceutical industry has grown from traditional products to far more high technology areas of manufacturing including biotech products. Along with this growth has come responsiblity of quality products.

Shri Pethaljibhai Chavda is a leading educationalist and industrialist of Junagadh district who has devoted his life for the pious purpose of providing education and 'Sanskaras' to the future of the country. As he strongly believes that education echoes the moral and knowledge of the country. He has dedicated the best of his life years for the development of the education and made efforts to embody values in the students.

About Author:
Brijesh Borad,
The University of London Metropolitan University,
London, UK
borad_brijesh@yahoo.com

Abstract :-
Breast cancer is widely spreaded type of cancer in women and responsible for high number of cancer death in women. Taxol has been already approved to be used for breast cancer by FDA. There have been several studies on the anti tumor activities of Vitamin E Succinate (VES) as complementary and alternative medicine. In present study, we investigated the cytotoxic effect of taxol-VES combination on MCF-7 breast cancer cell lines in comparison with taxol alone. MCF-7 cells are preffered because of higher sensitivity to estogens. MCF-7 cells were sub cultured in according to specifications of aseptic conditions by incubating at 37^οC and 5%CO2. Cells were seeded in 24 well plate with culture medium and different concentration of different drug regimen ( taxol alone, VES alone, taxol-VES combination) for 72hrs. Cell viability can be checked by MTT cell viability assay. MTT assay uses a MTT dye which acts as a substrate for viable cell reductase enzyme. This enzyme reduces MTT yellow dye to purple colour formazan which is in proportional to viable cell eventually. The intensity of purple colour was measured by measuring absorbances at 570nM using spectrophotometer. The results of the study were plotted as %cell viability Vs concentration for each of three drug regimen. IC50 values for each drugs were calculated. Graphical and statistical analysis of results concluded that taxol-MCF combination has more inhibitory effect on MCF-7 breast cancer cell lines when treated for 72hrs in comparison with taxol alone and statistical analysis had concluded that results were significant enough to accept clinically to use in stratagic breast cancer therapy management.