ABOUT AUTHORS:
A.Anil kumar, K.Surekha, M.Sujatha Kumari
Department of Pharmaceutics
Vikas college of pharmacy, Vissannapeta, 521215
*anilkumar.adi@gmail.com
ABSTRACT:
The objective of the present study of Diclofenac sodium was to treat inflammatory bowel disease in colon. Treatment for IBD is a long term therapy the colon drug delivery system of Diclofenac sodium to the colon provides the following benefits. Avoidance of first pass metabolism, to target local site. The tablet formulation of Diclofenac sodium provides time controlled release to treat the nocturnal symptoms of pain in colon. The formulation is administered in the night at 10 pm the action will be start early morning 3’0 clock Symptoms that are experienced in early morning hours should be avoided to maintain the lag period of drug release 5hrs. To maintain lag time the best method is pulsein cap drug delivery system and it is high expensive, poor in vivo correlation. Due to cost effectiveness and poor in vivo correlation we preferred to target colon as tablet dosage form. In the present study, the polymer selected as Guargum. Granules were prepared by wet granulation technique using Guargum in different ratios (drug: polymer) FG1 (1:0.25), FG2(1:0.5), FG3(1:0.75), FG4(1:1), FG5(1:1.25). To perform the interaction studies by IR spectra studies. To study the influence of polymer concentration on the Diclofenac sodium release from tablets. The prepared tablets were evaluated for different physical parameters and dissolutions studies were performed in 3 dissolution mediums like 0.1N hydrochloric acid for 2hr, pH 7.4 for 3hr, pH 6.8 up to 24hrs. Among all these formulations FG4 formula (1:1) showed 98% up to 24 hrs drug release. The release mechanisms of all formulations are diffusion controlled conformed from higuchis plot, thus the present study concluded that drug and guar gum (1:1) ratio for fulfill to target local site for colon drug delivery system.