Pharmaceutics Articles

About Authors:
Dharmendra Kumar*, BhanuPriya, S.K Gupta
*Department of Pharmaceutical Technology,
Meerut Institute of Engineering and Technology,
Meerut, Uttar Pradesh, India, 250005
*rvnimiet@gmail.com

Abstract.
The aim of this research work was replaced the tablet or injection of Domperidone by using domperidone nasal gel forrmulations. In research, day to day newer novel drug delivery comes for various drugs nasal gel drug delivery system one of them. Purpose of this study is formulating a nasal gel of Domperidone by using natural mucoadhesive agent extract from Dellinia Indica. In vitro drug release study carried out by using Franz-diffusion cell and excised bovine nasal membrane,characterisation was also found to be better in comparison to the HPMC and carbapolsynthetic polymers. Dellinia indica has valuable properties as a mucoadhesive agent because it is considered to be biocompatible, biodegradable and non-toxic. In future nasal gel formulations replace tablet/injection of Domperidone.

ABOUT AUTHORS:
A.Anil kumar, K.Surekha, M.Sujatha Kumari
Department of Pharmaceutics
Vikas college of pharmacy, Vissannapeta, 521215
*anilkumar.adi@gmail.com

ABSTRACT:
The objective of the present study of Diclofenac sodium was to treat inflammatory bowel disease in colon.   Treatment for IBD is a long term therapy the colon drug delivery system of Diclofenac sodium to the colon provides the following benefits. Avoidance of first pass metabolism, to target local site. The tablet formulation of Diclofenac sodium provides time controlled release to treat the nocturnal symptoms of pain in colon.  The formulation is administered in the night at 10 pm the action will be start early morning 3’0 clock Symptoms that are experienced in early morning hours should be avoided to maintain the lag period of drug release 5hrs. To maintain lag time the best method is pulsein cap drug delivery system and it is high expensive, poor in vivo correlation. Due to cost effectiveness and poor in vivo correlation we preferred to target colon as tablet dosage form. In the present study, the polymer selected as Guargum. Granules were prepared by wet granulation technique using Guargum in different ratios (drug: polymer) FG₁ (1:0.25), FG₂(1:0.5), FG₃(1:0.75), FG₄(1:1), FG₅(1:1.25). To perform the interaction studies by IR spectra studies. To study the influence of polymer concentration on the Diclofenac sodium release from tablets. The prepared tablets were evaluated for different physical parameters and dissolutions studies were performed in 3 dissolution mediums like 0.1N hydrochloric acid for 2hr, pH 7.4 for 3hr, pH 6.8 up to 24hrs. Among all these formulations FG₄ formula (1:1) showed 98% up to 24 hrs drug release. The release mechanisms of all formulations are diffusion controlled conformed from higuchis plot, thus the present study concluded that drug and guar gum (1:1) ratio for fulfill to target local site for colon drug delivery system.

ABOUT AUTHORS:
Manish Goswami, U.K.Singh, Rajat Kumar
Kharvel subharti college of pharmacy (swami Vivekanandsubharti University) Subhartipuram,
N.H-58, Meerut By Pass Road,
Meerut, uttarpradesh- 250001, India.
*manish.revosys88@gmail.com

ABSTRACT:
The desire of improved palatability in orally administered products has prompted thedevelopment of numerous formulations with improved performance and acceptability. Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last fewdecades, and the field has become a rapidly growing area in the pharmaceutical industry. Theunique property of mouth dissolving tablet is that they are rapidly disintegrating and/ordissolving and release the drug as soon as they come in contact with saliva, thus obviate therequirement of water during administration. this review also provides the detailed concept of some unique patents; technologiesdeveloped and marketed formulations of Mouth Dissolving Tablets(MDTs).The present investigation was undertaken with a view to develop mouth-dissolving tablets which offer a new range of product having desired characteristics and intended benefits. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The basic approach used in development of MDT is the use of super disintegrants like Crosslinked carboxymethyl cellulose (Croscarmellose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. whichprovide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva.