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  • PharmaTutor
    12 May 2013

    A REVIEW : APPROACH IN DENTAL DRUG DELIVERY SYSTEM

    ABOUT AUTHORS:
    Badola Ashutosh,* Nishu Sharma
    Shri Guru Ram Rai Institute of Technology & Science ( SGRRITS ),
    Dehradun 248001, Uttarakhand , India
    *ashutosh.badolam.pharma@gmail.com

    ABSTRACT:
    Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluate sustained release dental films containing drug in a non-biodegradable polymer for targeted delivery of the drug. The polymer ethyl cellulose was used in the formulation of dental films. The dental film was then evaluated for various parameters like thickness, folding endurance, and weight variation, and content uniformity, in vitro and in vivo study. Drug release profile of the dental film showed that the film exerted an initial burst release followed by a sustained release of the drug and the drug release was well above the minimum inhibitory concentration throughout the time of study. The release data obtained were subjected for release kinetics study. The study suggested that the non-biodegradable based dental film is a potential local drug delivery device for the treatment of periodontitis.

  • NUTRACEUTICALS
    10 May 2013
    NUTRACEUTICALS

    ABOUT AUTHORS:
    Miss Apoorva Bhatnagar1, Dr. S. C. Mahajan2
    1Mahakal institute of pharmaceutical studies,  
    2Director at Mahakal Institute of Pharmaceutical Studies,
    Ujjain (m.p.)  456010
    *apy1590bhtngr@gmail.com

  • COLON TARGETED DRUG DELIVERY SYSTEM- A NOVEL APPROACH : A REVIEW
    8 May 2013
    COLON TARGETED DRUG DELIVERY SYSTEM- A NOVEL APPROACH : A REVIEW

    ABOUT AUTHORS:
    Neha singh*1, Chandana Majee2
    1.M.Pharm ( Department of Pharmaceutics)
    2.Assistant Professor, Departmrnt of pharmaceutical chemistry.
    Noida Institute of Engineering and Technology, Noida
    *neha8april@gmail.com

  • IMPURITY PROFILE: - STUDY A BETTER WAY FOR QUALITY CONTROL OF PHARMACEUTICALS PRODUCTS
    7 May 2013
    IMPURITY PROFILE: - STUDY A BETTER WAY FOR QUALITY CONTROL OF PHARMACEUTICALS PRODUCTS

    ABOUT AUTHORS:
    *Ramchandra Gupta2, Prabhakar Sharma2, Prakash Pandey2, Pratik Jain1, Ajay Shukla3
    1Department of Pharmacognosy,
    2Department of Pharmaceutics,
    3Department of Pharmaceutical Chemistry

  • DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND LEVOCETRIZINE DIHYDROCHLORIDE IN BULK AND TABLET DOSAGE FORMULATION.
    5 May 2013
    DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND LEVOCETRIZINE DIHYDROCHLORIDE IN BULK AND TABLET DOSAGE FORMULATION.

    ABOUT AUTHORS:
    Gohel Bhavika A*, Patel Bhavna A, Parmar Sharddha J, Mital Sondagar M, Jadav Alpa V
    P G Department of Pharmaceutical Sciences, Sardar Patel University,
    V. V. Nagar, Gujarat
    *pharma.bhavika@gmail.com

  • MICRONEEDLES BASED TRANSDERMAL DRUG DELIVERY
    3 May 2013
    MICRONEEDLES BASED TRANSDERMAL DRUG DELIVERY

    About Author:
    Pooja Mittal
    School of Pharmacy and Emerging Sciences,
    Baddi University of Emerging Sciences and Technology,
    Baddi H.P
    pooja.mittal@baddiuniv.ac.in

  • A REVIEW ON MARKETING OF OTC DRUGS
    30 April 2013
    A REVIEW ON MARKETING OF OTC DRUGS

    ABOUT AUTHORS:
    Md. Yaqub Khan*, Poonam Gupta, Dr. Dipendu Goswami, Bipin Bihari, Vikas Kumar Verma
    Saroj Institute of Technology & Management,
    Ahimamau P.O. Arjunganj Sultanpur  Road,
    Lucknow  -226002
    *khanishaan16@yahoo.com

  • A REVIEW ARTICLE ON NANOPARTICLE
    29 April 2013
    A REVIEW ARTICLE ON NANOPARTICLE

    ABOUT AUTHOR:
    Shalu Shukla
    M.Pharmacy
    Bahra University
    shukla5828@gmail.com

    ABSTRACT
    The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Interestingly pharmaceutical sciences are using nanoparticles to reduce toxicity and side effects of drugs and up to recently did not realize that carrier systems themselves may impose risks to the patient. The kind of hazards that are introduced by using nanoparticles for drug delivery are beyond that posed by conventional hazards imposed by chemicals in classical delivery matrices. For nanoparticles the knowledge on particle toxicity as obtained in inhalation toxicity shows the way how to investigate the potential hazards of nanoparticles. The toxicology of particulate matter differs from toxicology of substances as the composing chemical(s) may or may not be soluble in biological matrices, thus influencing greatly the potential exposure of various internal organs. This may vary from a rather high local exposure in the lungs and a low or neglectable exposure for other organ systems after inhalation. However, absorbed species may also influence the potential toxicity of the inhaled particles. For nanoparticles the situation is different as their size opens the potential for crossing the various biological barriers within the body. From a positive viewpoint, especially the potential to cross the blood brain barrier may open new ways for drug delivery into the brain. In addition, the nanosize also allows for access into the cell and various cellular compartments including the nucleus. A multitude of substances are currently under investigation for the preparation of nanoparticles for drug delivery, varying from biological substances like albumin, gelatin and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles. It is obvious that the potential interaction with tissues and cells, and the potential toxicity, greatly depends on the actual composition of the nanoparticle formulation. This paper provides an overview on some of the currently used systems for drug delivery.

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  • PULSATILE DRUG DELIVERY SYSTEM AND RECENT ADVANCES: A REVIEW
    26 April 2013
    PULSATILE DRUG DELIVERY SYSTEM AND RECENT ADVANCES: A REVIEW

    ABOUT AUTHORS:
    Bhaskar Ingole, Shradha Tiwari*
    SSS. Indira College of pharmacy,
    Vishnupuri, Nanded
    *Shraddha.life10@gmail.com

    ABSTRACT:
    Pulsatile drug delivery aims to release drugs on a programmed pattern means at appropriate time and/or at appropriate site of action. Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance These systems are designed according to the circadian rhythm of the body. Pulsatile release of the drugs is used where a constant drug release is not desired.Gastric retentive systems, systems where the drug is released following a programmed lag phase, chronopharmaceutical drug delivery systems matching human circadian rhythms, multiunit or multilayer systems with various combinations of immediate and sustained-release preparation, are all classified under pulsatile drug delivery systems. On the other hand, site-controlled release is usually controlled by factors such as the pH of the target site, the enzymes present in the intestinal tract and the transit time/pressure of various parts of the intestine. In this review, recent patents on pulsatile drug delivery of oral dosage forms are summarized and discussed.

  • AN OVERVIEW: AQUEOUS FILM COATING TECHNOLOGY ON TABLETS
    26 April 2013
    AN OVERVIEW: AQUEOUS FILM COATING TECHNOLOGY ON TABLETS

    About Authors:
    Parmar Krutin D.1*, Pandya Kirtan B.2, Gajjar Alpesh M.3, Zala Shivraj D.3, Kela Amit N.1, Nathani Hitesh S.    1
    1*    C. U. Shah College of Pharmacy and Research, Wadhwan city, Surendranagar, Gujarat, India.
    2     Shree Balaji pharmacy college, Jaipur, Rajasthan, India.
    3    Shree V.B. Manvar college of pharmacy, Upleta, Gujarat, India.
    *krutinkp@gmail.com

    Abstract:
    Tablet coating is perhaps one of the oldest pharmaceutical processes still in existence. Earlier, Sugar coating was adopted for pharmaceutical as from confectionary industry. But as it was tedious process and required skilled manipulation, film coating was started to be preferred over sugar coating.  Development of film coating was mainly based on solutions of different polymers in various organic solvents. All these solvents are toxic in nature. Nobody ever was concerned about the problems like material cost, toxic effects due to coating or pollution etc. In today's competitive business environment, any cost saved will improve the market viability and success of any product. Therefore, left with no other choice but to eliminate the use of organic solvents and to start using water as the solvent system for tablet coating.
    The main focus of this review is, to study various aspects of aqueous based film coating.

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