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5 October 2016

Differentiate between PMR and 13 CNMR

Q.3. (b) How will you simplify complicated splitting pattern in PMR? Differentiate between PMR and 13 CNMR.
Ans.3. (b)Introduction:
The complete analysis of a compound is frequently made difficult, when signals overlap and as a result, useful information is often buried due to complexity of the spectrum. In a spectrum several signals may overlap as is the case, e.g., of closely related methylene groups in a molecule. In such a situation an intense, broad and compulsory unresolved signal, termed the methylene envelope may appears between δ 1-2. Another cause of complexity is where a coupling constant is comparable with the chemical shift different between the coupled protons. For these problems following techniques may use to solve them.

5 October 2016

How will you differentiate between first order and non-first order PMR spectra

Q.3.(a) How will you differentiate between first order and non-first order PMR spectra
Ans.3. (a)First order spectra:

For a spectrum to be first order, the frequency difference (∆v, in Hz) between any two coupled resonances must be significantly larger than the coupling constant that relates them. A first-order spectrum has ∆v/J > -6^3.
First-order resonances have a number of helpful characteristic, some of which are related to the number individual coupling, n:

5 October 2016

National Seminar on Price Regulations: Impact on Accessibility & Industry Perspective at Delhi

Considering the Indian population, the country's economic condition including the unequal distribution of wealth and particularly, the overall health issues faced by a substantially high number of people, the government is very active in ensuring equitable distribution and availability of medicines and medical technologies at fair prices. In respect of the price control of drugs, the central government acts through the National Pharmaceutical Pricing Authority (NPPA), a body that was set up in 1997 especially for this purpose.

Read more about Janssen present New Phase 3 Data In Treatment of Moderate to Severe Plaque Psoriasis

Janssen Research & Development, LLC (Janssen) announced findings from the first of three pivotal Phase 3 studies evaluating guselkumab, a subcutaneously administered anti-interleukin (IL)-23 monoclonal antibody in late-stage development for the treatment of adults with moderate to severe plaque psoriasis.

Read more about European Commission grant transfer of Alprolix® marketing authorisation to Sobi™

Swedish Orphan Biovitrum AB (publ) (Sobi™) announces that the European Commission (EC) has approved the transfer of the marketing authorisation for Alprolix® (eftrenonacog alfa), a recombinant clotting factor therapy developed for the treatment of haemophilia B, from Biogen[i] to Sobi, making Sobi the marketing authorisation holder (MAH) in the EU.

Read more about Aralez Pharma acquire rights to Toprol-XL tablets in US from AstraZeneca

AstraZeneca has entered into an agreement with Aralez Pharmaceuticals Trading DAC, a subsidiary of Aralez Pharmaceuticals Inc., for the rights to branded and authorised generic Toprol-XL (metoprolol succinate) in the US. Toprol-XL is a beta-blocker medicine for the control of hypertension (high blood pressure), angina (chest pain) and heart failure. It was first approved in the US in 1992.

Read more about Yoshinori Ohsumi : Nobel Prize Winner for Medicine

This year's Nobel Laureate discovered and elucidated mechanisms underlying autophagy, a fundamental process for degrading and recycling cellular components.

The word autophagy originates from the Greek words auto-, meaning "self", and phagein, meaning "to eat". Thus,autophagy denotes "self eating". This concept emerged during the 1960's, when researchers first observed that the cell could destroy its own contents by enclosing it in membranes, forming sack-like vesicles that were transported to a recycling compartment, called the lysosome, for degradation. Difficulties in studying the phenomenon meant that little was known until, in a series of brilliant experiments in the early 1990's, Yoshinori Ohsumi used baker's yeast to identify genes essential for autophagy. He then went on to elucidate the underlying mechanisms for autophagy in yeast and showed that similar sophisticated machinery is used in our cells.

Read more about Sanofi Pasteur received approval for Dengvaxia® dengue vaccine

Sanofi Pasteur, the vaccines global business unit of Sanofi, announced Dengvaxia® dengue vaccine has now received its 11th marketing approval, four of which granted from Regulatory Authorities recognized by the World Health Organization (WHO). To date the vaccine is approved in Mexico, The Philippines, Brazil, El Salvador, Costa Rica, Paraguay, Guatemala, Peru, Indonesia, Thailand and Singapore.

4 October 2016

Faculty Recruitment at NMIMS University

The vision of NMIMS University is to define the 21st century technological and management research. Hence the goal for NMIMS University is to encourage excellence in research and publication activities. Research is a precursor to discovery and innovation. The University systems survive on the strength of research i.e. knowledge creation and dissemination system. Realities of the modern world demand interdisciplinary research or research that cuts across the traditional boundaries of discipline.

Post : Faculty

4 October 2016

Job as QC Officer in reputed Pharma company - Client of Nurture consultancy - 08 Posts

We are hiring for an QC Officer/Executive for a Reputed Pharmaceutical Industry (Formulation) in Nashik location.