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  • PharmaTutor
    13 September 2012

    PREPARATION AND EVALUATION OF BIODEGRADABLE ALBUMIN MICROSPHERES OF DICLOFENAC SODIUM

    About Authors:
    Renu1*, Shashi Kant2*, Rajendra Yadav3, Amit Kumar Tyagi4
    1Faculty of Pharmacy, Shivdan Singh Institute of Technology and Management, Aligarh (U.P)
    2Jubilant Chemsys Ltd, Noida,
    3Department of Pharmaceutical Sciences, Gurukul Kangri University Haridwar, 
    4Department of Chemistry, Meerut College, Meerut (U.P)
    *shashi.pharma83@gmail.com

    ABSTRACT :
    Diclofenac is currently the eighth largest-selling drug and the most frequently used NSAID (Non-steroidal anti-inflammatory drug) in the world, since its introduction in Japan in 1974. Diclofenac is among the better tolerated NSAIDs. Only major adverse effect of Diclofenac is that it causes direct and indirect irritation of the gastrointestinal tract (GIT). To reduce the side effects on gastrointestinal tract (GIT) and to improve therapeutic efficacy of Diclofenac, it can be formulated in polymeric microspheres.
    The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible to target drugs and provide controlled release. Diclofenac sodium (DS), is a potent drug in the NSAID group having non-steroidal, anti-inflammatory properties, and is widely used in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. In this present study, it was aimed to prepare microsphere formulations of DS using a natural biodegradable polymer as a carrier for administration to extend the duration period of the dosage form. Microsphere formulations of DS which were prepared were evaluated in vitro for particle size, yield value, encapsulation efficiency, surface morphology, and in vitro drug release.

  • Vertigo Management – Mapping prevalence and treatment. Understanding once a day preparation usage and place in therapy.
    11 September 2012
    Vertigo Management – Mapping prevalence and treatment. Understanding once a day preparation usage and place in therapy.

    About Authors:
    Indraneel sinha*, Mr. Sanjay sahai, Mr. Sunil jajoo, Mr. Abhijeet bhatkar
    Post graduate diploma in pharmaceutical management,
    Indian institute of health management research,
    jaipur
    *indraneel.sinha.999@gmail.com

    COMPANY PROFILE
    Sun Pharmaceuticals was set up in 1983 and the company started off with only 5 products to cure psychiatric illness.  Sun Pharma is best known worldwide as the manufacture of specialty Active Pharmaceuticals Ingredients (API) and formulations.

    However, the company is also concerned with chronic treatments such as cardiology, psychiatry, neurology, gastroenterology, diabetology and   respiratory ailments. Active Pharmaceuticals Ingredients (API) includes peptides, steroids, hormones, and anti?cancer drugs and their quality is internationally approved. Mr. Dilip S. Shanghvi is the Executive Chairman and Managing Director of Sun Pharma and Mr. Kamalesh H. Shah is the secretary.

  • SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND AMLODIPINE IN RAW MATERIAL AND IN COMBINED TABLET DOSAGE FORM BY RP-HPLC
    10 September 2012
    SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND AMLODIPINE IN RAW MATERIAL AND IN COMBINED TABLET DOSAGE FORM BY RP-HPLC

    About Authors:
    Kapil Sharma*1, Subhash Gupta 2
    1 Yaresun Pharmaceutical Pvt. Ltd.,India.
    2 Oasis test house ltd. Jaipur-302006, Rajasthan, India.
    *pharma_kapil@rediffmail.com

    ABSTRACT
    A method for simultaneous estimation of Atorvastatin (ATVS) and Amlodipine (AMLD) in raw material and in combined tablet dosage form has been developed. The method employs the application of RP-HPLC. Chromatgraphy was carried out on a nucleosil C-18,250 x 4.6 mm column using a mixture of phosphate buffer and methanol  (50:50 v/v)  as the mobile phase at a flow rate of 1.3 ml/min.  Run time was 15 min.  Detection was done at 245 nm and retention time of ATVS was 6.97 min and 3.96 min of AMLD.3  This method produced linear responses in the concentration range 20-140 µg/ml and 10-70 µg/ml for ATVS and AMLD respectively. The accuracy of the method was assessed by recovery studies and was found to be 100.54± 0.19 and 100.08±0.80 for ATVS and AMLD respectively.The procedure was successfully applied for the simultaneous determination of both drugs in laboratory prepared mixture of raw material and in market available tablet dosage form. Results of the analysis were validated statistically so that it can be used for routine analysis of ATVS and AMLD in combined tablet dosage form.4-6

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