Review Articles

About Authors:
Birajdar Shivprasad M.*, Mulaje S.S., Patil B.R., Sorde M.B., Dr.Bhusnure O.G.
*Maharashtra College of Pharmacy, Department of Quality Assurance, Nilanga-413521,
Dist. Latur (Maharashtra) India
*birajdar100@gmail.com

Abstract:
Production Planning & Control is an important aspect & separate department for any production oriented pharmaceutical industry. The basic objective of the manufacturing organization is to make the products. Thus the production is the nucleus or the centre of entire business operations. It must be emphasized, however, that on signal system of forecasting, preplanning, planning and control is suited to all industrial enterprises, no matter how well it may meet the needs of this on that special company. PPC functions look after the manufacturing activities.

About Author:
Kambham Venkateswarlu
Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
The term superbug is a nonspecific word that is used to describe any microorganism that is resistant to at least one or more commonly used antibiotics. Some authors restrict its use to microorganisms resistant to two or more antibiotics.

The most common bacteria described as superbug are the following:
* MRSA (Staphylococcus aureus strains resistant to multiple antibiotics)
*  VRE (Enterococcus species resistant to vancomycin)
*  PRSP (Streptococcus pneumonia strains resistant to penicillin)
*  ESBLs (Escherichia coli and other Gram-negative bacteria resistant to antibiotics such as cephalosporins and monobactams)

Emerging superbugs may be multiple drug resistant Clostridium difficile, VRSA (vancomycin resistant S.sureus) and NDM Escherichia coli (New Delhi metallo-beta-lactamase resistant E.coli).

About Author:
Kambham Venkateswarlu
Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
It is the branch of medicine that involves introducing new cells into a diseased tissue to trigger the body’s ability to heal itself.
Cell therapy includes stem cell therapy, which means harvesting, transplantating or implanting stem cells in order to make healing mechanisms available in the diseased or damaged tissue itself. These stem cells may be harvested from the body of the mature adult from specialized sites where it is available such as the marrow of large bones or they may be preserved stem cells, harvested from the Umbilical cord blood or cord tissue at the time of that person’s birth.
They may also be from another donor. If the donor of the stem cells is the same as the patient in whom it is transplanted, it is called autologous cell therapy. If the donor is a different person, it is called allogenic stem cell therapy.

About Authors:
Sharma Monish*, Kumar Bhupender, Bhardwaj Sudeep
Seth G.L Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research.
Sri Ganganagar, Rajasthan (INDIA)
*monish28sharma@gmail.com

ABSTRACT :
During the recent past, a dramatic rise in the use of herbs and herbal remedies has been witnessed in many parts of the world.  While such products had been used with apparent safety in traditional societies for many centuries, when they are being combined with pharmacological agents, posses the possibility of potential interaction between the two groups of substances. In this situation, herb-allopathic drug interaction is an important factor to be measured because there is always a chance to get undesirable therapeutic effect of the prescribed allopathic drug, as like allopathic (prescription) drugs. Herbal medicines also have different pharmacokinetic and pharmacodynamic properties which ultimately lead to produce therapeutic responses, but sometimes cause adverse actions and/or drug-herbal interactions. Drug interaction refers to the situation where two or more separate drugs have been absorbed into the body and their effects are affected by each other, i.e. the effects are increased or they produce a new effect that neither produces on its own. The aim of this article is to highlight the interactions between herbal remedies and prescribed drugs.

About Authors:
Lohithasu Duppala^*1, Madhu priya Damuluri¹, Anil kumar vadda^2
1GITAM Institute of Pharmacy, GITAM University, Pharmaceutics, visakhapatnam, Andhra Pradesh, India-530045.
²AVANTHI Institute of pharmaceutical sciences, pharmacology, visakhapatnam, Andhra Pradesh, India-530045.
^*lohithasu@gmail.com, anilkumar.vadda@gmail.com

ABSTRACT:
COX-2 (Cyclooxygenase-2) is a selective inhibitor of non-steroidal anti-inflammatory drug (NSAID). Cyclooxygenase -2, an enzyme responsible for inflammation and pain. Celecoxib, Rofecoxib, valdecoxib, Parecoxib are class of COX-2 inhibiting drugs. COX-2  inhibitors have been revealed to reduce the occurrence of cancers and pre-cancerous growths. Celecoxib, cox-2 inhibitor isused to prevention of polyp formation in Familial Adenomatous Polyposis (FAP). COX-2 inhibitors like celecoxib, Rofecoxib, valdecoxib, Parecoxibare currently being studied in  cancer treatment and other targets. This review highlights the COX-2 inhibitors with special emphasis on their role in various kinds of cancer prevention and other targeted therapy. COX-2 inhibitors in cancer chemotherapy and neurological diseases like Parkinson and Alzheimer’s diseases still continues to attract researches on the development of COX-2 inhibitors.

About Authors:
Kambham Venkateswarlu
Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
The International Conference on Harmonization of technical requirements of pharmaceuticals for human use was established in 1990 as a tripartite venture representing regulatory bodies and research based industry. The major aim of ICH is to provide a forum for constructive discussion on the real and perceived differences in technical requirements for the registration of new chemical entities. Other objectives are: To achieve greater harmonization in the interpretation and application of technical guidelines for the registration of new active substances or products obtained by biotechnology by its members; to improve the efficiency of global drug development; to reduce redundant studies; and to improve pharmacovigilance activities and quality assurance.

About Author:
Kambham Venkateswarlu
Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
The diet is selection of food eaten by an individual. A balanced diet is essential for health. It provides the appropriate amounts of all nutrients in the correct proportions to meet body requirements.
An essential nutrient is substances that cannot be made by the body and must be supplied through the diet. Foods are described as carbohydrate or protein because they contain a higher proportion of one or the other. A balanced diet contains all nutrients required for health in appropriate proportions and is normally achieved by eating a variety of foods.