Fresher Post Graduate in Pharmacy / Chemistry invited as Associate Scientist in CavinKare

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals.

Biocon is a research-driven, global healthcare company with a strong matrix of capabilities along the biopharmaceutical value chain. Focusing on unmet medical needs in cancer, diabetes and inflammatory diseases, it offers novel therapies on a platform of affordable innovation.

bioCampus, GVK Biosciences is leading Informatics Services provider with wide range of Products and Services across the R&D value chain. Considered a market leader in the development of MANUALLY curated databases, GVK BIOs databases on SAR, PK/Tox and other areas are widely used in the industry and their utility have been well documented in the scientific literature.

The National Brain Research Centre (NBRC) was established by the Department of Biotechnology, Ministry of Science & Technolgy, Government of India, in November 1997 as a fully funded autonomous research institute in the area of neuroscience and brain. The Centre was registered as an Society in June 1999 under the Registration of Societies Act.

About Authors:
ATUL KABRA^* , PREMAL KAPADIA
Department of Pharmacology,
G.H.B Pharmacy college,
Aniyad, Gujarat
* atul.kbr@gmail.com

ABSTRACT:
The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

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About Authors:
¹Shashi Kant^*, Satinder Kumar,
Research Scholar Department of Pharmacy.
²Dr. Bharat Prashar
HOD & Associate professor,
Department of Pharmaceutical Sciences,
Manav Bharti University, Solan (H.P)
* shashi_ranaute@yahoo.in

Abstract:
In this general overview, we discussed about dentifrices, types of dentifrices, formulation, evaluation and its recent trends. There have been many dentifrices produced over the years, many focusing on marketing strategies to sell products, such as offering whitening capabilities. The most essential dentifrice recommended by dentists is toothpaste which is used in conjunction with a toothbrush to help remove food debris and dental plaque.

Translational Health Science and Technology Institute (THSTI) an initiative of Department of Biotechnology, Government of India and International AIDS Vaccine Initiative (IAVI), USA are seeking Principal Investigators for their new joint collaborative program to accelerate and advance HIV vaccine research and development.

Wipro Infotech is the leading strategic IT partner for companies across India and Middle East - offering integrated IT solutions. We plan, deploy, sustain and maintain your IT lifecycle through our total outsourcing, consulting services, business solutions and professional services.

The Guru Jambheshwar University of Science & Technology, Hisar, was established on October 20,1995 by an Act of the Legislature of the State of Haryana with the objectives 'to facilitate and

Sorbead India is an ISO 9001 accredited fast growing organization engaged in manufacturing & exports of "Adsorbents & Desiccants" The company is in explosive growth phase and is looking for personnel for its various divisions. We are looking for dynamic & result oriented achievers who have abilities to take challenges. Following are recent openings for our Vadodara Office:

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North Eastern Railway has issued notification against recruitment of 65 various vacancies under Special Recruitment Drive against Physically Handicapped Quota. Eligible candidates may apply through prescribed application format on or before 06-08-2012. Other details like age limit, educational qualification, application fee details, selection process and how to apply are given below

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Aurobindo Pharma had gone public in 1995 by listing its shares in various stock exchanges in the country. The company is the market leader in semi-synthetic penicillin drugs. It has a presence in key therapeutic segments like SSPs, cephalosporins, antivirals, CNS, cardio-vascular, gastroenterology, etc.

Abbott India Limited is a subsidiary of Abbott Laboratories, USA, a global, iversified health care company devoted to the discovery, development, manufacture and marketing of pharmaceutical, diagnostic, nutritional and hospital products. The company now employs approximately 70,000 people and markets its products in 130 countries worldwide.

Applications are invited from CSIR-UGC JRF/ ICMR-JRF/ DBT-JRF/ DST inspired fellows for position of JRF in Immunology

Post: JRF in Immunology

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Abbott India Limited is a subsidiary of Abbott Laboratories, USA, a global, iversified health care company devoted to the discovery, development, manufacture and marketing of pharmaceutical, diagnostic, nutritional and hospital products. The company now employs approximately 70,000 people and markets its products in 130 countries worldwide.

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia.

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu.

About Authors:
Purbajit Chetia*, Manash Pratim Pathak, Prerona Das
Deptt. of Pharmacology,
Himalayan Pharmacy Institute, Majhitar,
Rangpo, E- Sikkim(737132)
*purbasiv@yahoo.com

ABSTRACT:
A free radical is an atom or group of atoms that contains at least one unpaired electron and can easily bond with another atom or molecule, causing a chemical reaction. Free radical is essential for body’s normal physiological functions. But when produced in excess quantities it can causes damage to the cells of the body. Human body generates pro-oxidants in the form of ROS and RNS which are effectively kept in check by the various levels of antioxidant defense. However, when it gets exposed to adverse physicochemical, environmental or pathological agents this delicately maintained balance is shifted in favor of pro-oxidants resulting in ‘oxidative stresses’. It has been implicated in the etiology of several human diseases including Rheumatoid Arthritis (RA) and in the process of ageing.At high concentrations, ROS can be important mediators of damage to cell structures, nucleic acids, lipids and proteins in case of the patients those who are suffering from RA. The hydroxyl radical is known to react with all components of the DNA molecule, damaging both the purine and pyrimidine bases and also the deoxyribose backbone.  Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and tissue around the joints with infiltration of macrophages and activated T cells. The pathogenesis of this disease is linked predominantly with the formation of free radicals at the site of inflammation. The review is focusing the evidences concerning the involvement of free radicals in Rheumatoid Arthritis and their relationship to specific pathophysiological events.