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Spectrophotometric Methods for Simultaneous Estimation Of Pyrimethamine And Sulphadoxine In Bulk Drug And Pharmaceutical Formulations

About Authors:
Kalpesh N. Patel1*, Jayvadan K. Patel2
1 Research Scholar, Jodhpur National University, Jodhpur,
Rajshathan, India
2 Department of Pharmaceutical Technology,

Nootan Pharmacy College,
Visnagar (GUJARAT), India.

Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of pyrimethamine and sulphadoxine from tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 215 nm (λmax of pyrimethamine) and 254 nm (λmax of sulphadoxine) in methanol and Method-II first order derivative spectroscopic method involves the measurement of absorbances at two wavelengths 250 nm (λmax of pyrimethamine) and 220.5 nm (λmax of sulphadoxine); The linearity lies between 5-30 µg/ml for both pyrimethamine and sulphadoxine for all the two methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of pyrimethamine and sulphadoxine in bulk and combined dosage form.

Vacancies in INDIAN MEDICINES PHARMACEUTICAL CORPORATION LIMITED (A Government of India Enterprise) - 3 posts

The Company (Manufacturing Ayurvedic and Unani Medicines) having obtained drug licence from licensing authority (G.M.P.

Walk in for Multiple Openings in Span Diagnostics | Requirement in QC, R&D, Analytical Development Chemist, QMS, Packaging and Validation areas

Career in MARC as ZBM, RBM, ABM, FSO, SALES-ADMIN | Walk in Interview

Marc is a fast growing pharma company with comprehensive multi segment range of quality products under ISO 9002, WHO GMP Certification & having its own Manufacturing Plants.
A Reputed & Professionally Managed Pharmaceutical Company require Professionals for their New Division ACENTRIA (Pharma Div.) & REOX (Cardio Diabetic & CNS Div.)

Professor/Associate Professor and Asst. Professors required in Dev Bhoomi Group Of Institutions

DBIPR is situated in separate premises in Dev Bhoomi Campus Dehradun. The Institute offers AICTE & PCI Approved Four Year B.Pharmacy and 2 Year M.Pharmacy(Pharmacology) Courses Affiliated to Uttrakhand Technical University, Dehradun.

Post: Professor/Associate Professor and Asst. Professors

Require General / Deputy General Manager - Sales, Zonal Sales Manager {West Region} in Centaur Pharma

Centaur Pharmaceuticals is among the few, fully integrated pharmaceutical players in India with major presence in formulations, API, contract research and contract manufacturing, with exports to over 60 countries. On the domestic front, Centaur Pharmaceuticals is among India's Top Pharmaceutical players with six brands ranking first in respective therapeutic segments.

Vacancies as Pharmacist. Gr.II in Kerala Public Service Commission - 3 posts

The Kerala Public Service Commission is a body created by the Constitution of India.

Walk in for the post of Research Associate in National institute of Nutrition

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr.

Need for Professional And Social Change In Pharmaceutical Education

About Authors:
Gedam V.K., Chikhle R.V.
University Department of Pharmacutical Sciences,
Rashtrasanta Tukdoji Maharaj
Nagpur University,
Amravati road, Nagpur-440033,
M.S.,India

ABSTRACT
The natual sciences simply do not provide adequate tools or perspective.They need to be supplemented with knowledge from disciplines that deals with people and system. The social development has always been closely interlinked with healthcare achievements. Therefore Pharmacy education and practice has significant impact on health improvement of nation.The pharmacist represent the third largest professional group in the world which works in community a member of  healthcare team and have special responsibilities for safe use of medicines.
In India, profession of Pharmacy is yet to boom to its fullest extent. Here Pharmacist performs job of mere drug seller only and does not practice Pharmacy independently.In developed countries in addition to traditional dispensing Pharmacist monitor the health and progress of patient and provide patient care outcomes and accordingly their education curriculum is designed.
This paper seeks a need for professional and social change in pharmaceutical education system for achieving the  desired status of pharmacist in our country. The standard of education must be evaluated for strengthening of education and profession.

Submitted by admin on 19 January 2012
DEAR SIR/MADAM I AM B.PHARMA GRADUATE WITH 2 YEAR PHARMA SELLING EXP AND ALSO DONE MBA THROUGH DISTANCE.I WANT TO KNOW.HOW I WILL ENTER INTO PMT DEPART.WHAT ARE THE SKILL AND THINGS REQUIRE FOR THIS DEPART.I AM WAITING YOUR POSITIVE REPONSE.PLEASE ANYBODY GIVE ME THE ANSWER OF THIS QUESTION.?????????/
RANBAXY invites applications through WALK IN INTERVIEW for the posts of Front Line Sales Professionals

Ranbaxy, India's largest pharmaceutical company having a presence in Anti Infective, Respiratory, Pain Management, Derma, Ortho, Intensive Care, CNS, Oncology, Nephrology, HIV, CV, Urology and Gastro segments in India.
As a part of the expansion drive and ongoing requirements we are looking for young, dynamic and committed Front Line Sales Professionals in Mumbai and rest of Maharashtra.

Work in J. B. Chemicals & Pharmaceuticals as Officer in Formulation & Development - 4 posts

J. B. Chemicals & Pharmaceuticals Ltd. (JBCPL), known to many as Unique Pharmaceutical Laboratories is one of India's leading global pharmaceutical companies. The company manufactures and markets a wide range of pharmaceutical formulations.

Post:  Officer in Formulation & Development

Submitted by admin on 18 January 2012
Forums

Government of Maharashtra shall conduct a single combined “Common Entrance Test” MHT-CET-2012 for all Health Sciences, Engineering and Pharmacy degree courses for the academic year 2012-2013. The said Common Entrance Test will be held on Thursday, 10th May 2012. Detailed program regarding issue of application forms and information brochures will be announced later.

Job in i3 global for the post of Manager - Medical Writing

i3 is a full-service Clinical Research Organization (CRO) focused on five therapeutic areas: Oncology; Cardiology; The Central Nervous System; Respiratory and Infectious Diseases; and Endocrinology and Metabolic diseases. Therapeutic specialization drives all aspects of business in this global CRO - from project staffing and talent management to quality initiatives.

Antibacterial Activity of Mussa acuminata Colla- medium (Interest to Wild Edible Plants of Tribal People of Tripura)

About Authors:
Jyotirmoy Das Choudhury, Dr. Biplab De,
Department of Pharmaceutical Chemistry.
Regional Institute of Pharmaceutical Science and Technology. Abhoynagar, Agartala,
Tripura(W)

INTRODUCTION
Nature always stands as a golden mark to exemplify the outstanding phenomenon of symbiosis. The biotic & abiotic elements of nature are all interdependent. The plants are indispensable to man for his life. The knowledge of drug has accumulated over  thousands of years as a result of man’s inquisitive nature so that today we posses many effective means of ensuring health care.
In the part, almost all the medicines used were from the plants, the plant being men’s only chemist for ages. The history of medical plants dates back to RIG VEDA, perhaps the oldest repository of human knowledge, which was written in about 4500-1600 B.C. then there is the Ayurveda which given us detail accounts of many herbal drugs. Most of the medicinally active substance are identified in the 19th & 20th centuries was used in crude form. But now in modern days we use to take drug in the form of dosage form.

A REVIEW ON WOUND HEALING AGENTS OBTAINED FROM NATURAL SOURCES

About Authors:
Saravana Kumar K, Ramesh Y*,  
Department of Pharmaceutics,
Seshachala College of Pharmacy,
Tirupathi – Chennai High way,  
Puttur-517 583,  Chittoor (dist),
A.P., India

Abstract
Plants and their extracts have immense potential for the management and treatment of wounds. Wound healing is complicated process that involves four phases: (i) coagulation begins immediately after injury, (ii) Inflammation which begins within hours, (iii) Proliferation which begins within days, (iv) Remodeling up to period of week, months, up to year. The phyto medicine for wound healing are not only cheap and affordable but are also purportedly safe as hypersensitive reactions are rarely encountered with the use of these agents. Mainly these crude drugs are obtained from various climatic conditions Collection, cultivating, Harvesting & Isolation of active ingredients to treat various types of diseases.

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WALK IN INTERVIEW : Opening of Junior Research Fellow in IHBT - 2 posts

Govt. of Himachal Pradesh took up initiative in early seventies to set up a CSIR lab to make prudential use of the natural resources of the region.

Quantitative Estimation of Piperine in Ayurvedic Formulations by HPTLC

About Authors:
Ujjwal S. Yeotkar*, Mahendra Nimbhorkar, Tushar A. Deshmukh, Vijay R. Patil
Department of Pharmacognosy,
Tapi Valley Education Society’s,
Hon’ble, Loksevak Madhukarrao Chaudhari College of Pharmacy,
North Maharashtra University,
Faizpur- 425 503,
Maharashtra, India.

ABSTRACT
Churna are important group of formulation used by Ayurvedic physicians to treat various types of diasease. Trikatu and Pimpali churna, as per Ayurvedic literature is used for the treatment of resperatory disorders. In the present study,an attempt has been made to develop a HPTLC  method of quantitative estimation of marker compound, piperine in laboratory prepared authentic formulation and a marketed formulation of Trikatu and Pimpali churna. The stationary phase used was precoated silica gel G 60 F 254 plates. The mobile phase containing n- Hexane-ethyl acetate, (5:5 v/v ), was used to separate the spot of Piperine. Plates were developed to a distance of 8 cm at room temperature. Spectrodensitometric scanning was performed by TLC scanner III (CAMAG) in absorbance mode at the wavelength of 339nm. The  Rf  values of  piperine was 0.44± 0.02. The method was validated in terms of Linearity, Accuracy and  Precision. The linearity curve found to be linear in between 200–900 ng/spot. The limit of Detection (LOD) and limit of Quantification (LOQ) were found to be  1 ng and  3 ng respectively. The mean results from % Recovery was found to be, laboratory formulation contain 85.13% and 83.47% while the commercial formulation shows 96.65%, and 90.32% respectively. The proposed method can be used to determine Piperine from Ayurvedic formulations.

A STUDY ON ANTIULCER ACTIVITY OF ACACIA LEAUCOPHLOEA BARK EXTRACT IN PYLORUS LIGATED RATS

About Authors:
Kapil Patel, Supriya Hazra Das
Department of Pharmacology
Shree Dhanvantary Pharmacy College,
Kim, Surat – 394118,
Gujarat, India

Abstract:  
Peptic ulcer is a condition where benign lesions of gastric or duodenal mucosa occur at a site where the mucosal epithelium is exposed to acid and pepsin, due to imbalance between offensive and defensive factors. Acacia leucophloea, a deciduous tree found throughout India is reported to be used in gastric ulcer in traditional medicine. The present study was undertaken to evaluate the anti-ulcer properties of Acacia leucophloea in pylorus ligation ulcer model in rats. Acacia leucophloea was administered for 7 days and on 8th day 30 min prior to the induction of ulcers. Pretreatment with Acacia leaucophloea showed significant ulcer protection against pylorus ligation ulcer model as compared to control. Thus, the ulcer protective and healing effects of Acacia leucophloea may be due to its effect on both offensive and defensive factors. The present findings suggest that Acacia leucophloea has antiulcer properties.

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