DRIED BLOOD SPOT SAMPLING TECHNIQUE IN QUANTITATIVE ANALYSIS OF SMALL MOLECULES- A REVIEW
ABOUT AUTHORS:
Bhimavarapu Ramya Reddy*1, Bhavna Priyasri S2
*1Department of Pharmaceutical Analysis, A.M Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India
2Department of Pharmaceutical Engineering, New Jersey Institute of Technology, New Jersey, U.S.A.
ramyareddy.bh@gmail.com
ABSTRACT:
Dried blood spots (DBS) as an attractive alternative to conventional venous plasma sampling in many pharmaceutical companies and clinical laboratories, different analytical approaches have been developed to enable automated handling of DBS samples without any pretreatment. DBS offers a number of advantages over conventional blood collection. As a less invasive sampling method, DBS offers simpler sample collection and storage and easier transfer, with reduced infection risk of various pathogens, and requires a smaller blood volume. DBS-LC-MS/MS has emerged as an important method for quantitative analysis of small molecules. This technique is Widely used to screen for metabolic problems in newborn babies, PK studies. The objective of this review is to describe the analytical concepts of current direct DBS techniques along with DBS sample collection, processing and storage and to present their advantages and disadvantages.
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