About Author:
ATUL KABRA*, NITIN PATEL
Department of Pharmacology
G.H.B Pharmacy college,
Aniyad, Gujarat
* atul.kbr@gmail.com

ABSTRACT:
The antiulcer effect of aqueous fruit extract of Zizizphus jujuba was studied in ethanol induced ulcer model in rats. The extract dose of 50 mg/kg, 100mg/kg, 200 mg/kgproduced significant inhibition of gastric lesion induced by ethanol. The extarct reduced ulcerative lesion, gastric volume, total acidityin ethanol induced ulcer model.The result obtained suggesting that extract possesses significant antiulcer activity. 

Juggat Pharma, Pharmaceutical Division of Jagdale Industries Limited is one of the fastest growing and high performing pharmaceutical marketing company with a global presence based at Bangalore, Karnataka. We provide an ideal environment for highly qualified and committed professionals to pursue their career Under the expansion plan, we are looking for 'Marketing Professionals' in Gujarat/Rajasthan/Madhya Pradesh.

A cosmeceutical division of Origo Pharmaceuticals Pvt. Ltd. Cosmonova objective is - Beautiful you. We believe in bringing super specialty innovative cosmeceuticals products for discovering the beauty from inside. Beauty is our business and Orinova is on mission to serve every fraternity who is into bringing beauty especially Dermatologist / Cosmetologist / Trichologist, etc with specialized products.

Natural Remedies, a pioneer in phytopharmaceuticals is today credited with integrating scientific approach to search medicines and health supplements ensuring purity, safety and affordability.

The National Brain Research Centre (NBRC) was established by the Department of Biotechnology, Ministry of Science & Technolgy, Government of India, in November 1997 as a fully funded autonomous research institute in the area of neuroscience and brain. The Centre was registered as an Society in June 1999 under the Registration of Societies Act.

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology,

DENMARC REMEDIES; delhi based pharmaceutical company having operations in Delhi & Haryana. We are looking for Fresher/ Experienced medical representative / Territory Executive for Delhi who are energetic and ready to take challenges.

Post: MEDICAL REPRESENTATIVE/TERRITORY EXEC.

About Author:
Patel Sanjay P
Sanjeevan College Of Pharmacy,
Behind Shyam Sarovar Township,
Jaipur-Agra Highway,Dausa-303303,Rajasthan
sanonly4frdz@gmail.com,sanjay_411987@yahoo.com

1.Abstract
Aceclofenac is a drug with narrow therapeutic index and short biological half-life, so can achieve steady state concentration rapidly. This study was aimed at developing and optimizing niosomal formulation of aceclofenac in order to improve its bioavailability as compare to liposomes.This niosome is prepared by modified ether injection technique. In this span 60 & span 20 is used as non ionic surfactants. Different 6 formulation are prepared, In this NFS-1 to 3 formulation are prepared using the span 60 & NFS-4 to 6 are prepared using span 20 along with different proportion of cholesterols. Because of the presence of nonionic surfactant with the lipid, there is better targeting of drugs to tumor, liver and brain. In evaluation study, the effect of the varying composition of non ionic surfactant and cholesterol on the properties such as drug entrapment efficiency, drug content, particle size & shape and drug release were studied. Moreover, the release of the drug was also modified and extended over a period of 72 h in all formulations. NSF-3 emerged as the most satisfactory formulation. Further, release of the drug from the most satisfactory formulation NSF-6 was evaluated through dialysis membrane to get the idea of drug release. The mechanism of dug release was governed by K- Peppas model. In all the niosomes prepared with spans, as the concentration of surfactant increased drug entrapment efficiency increased. Among the spans, span 60 having high phase transition temperature (gel to liquid transformation) and having critical packing parameter (CPP) ranging from 0.5 to 1 entrap drug molecule without any cholesterol. The only drawback of span 60 vesicles was rapid leakage of drug from the vesicle because of high phase transition temperature. In all the cases the best fit model was found to be Peppas with ‘n’ value between 0.65 to 0.73 suggesting the non fickian (anomalous) release mechanism for the drug i.e., erosion followed by diffusion controlled. Formulation NSF-6 showed high entrapment efficiency (96.07%±0.35), particle size (4.22±0.47μm) and drug release (87.21%) over 72 h. Hence it was considered to be good niosomal formulation with greater bioavailability.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences.

GVK Biosciences (www.gvkbio.com) is leading Informatics Services provider with wide range of Products and Services across the R&D value chain. Considered a market leader in the development of MANUALLY curated databases, GVK BIOs databases on SAR, PK/Tox and other areas are widely used in the industry and their utility have been well documented in the scientific literature. For more information please log into www.gvkbio.com

About Authors:
Sriharsha Vardhan
SRM College of Pharmacy,
Chennai, Tamil Nadu
sriharshavardhan.51@gmail.com

ABSTRACT
The present study is formulating Rabeprazole modified release beads (Immediate and Time, Pulsatile Release) and to target the release of the drug in intestine and to avoid stability related problems. Preparation of immediate release (IR) Rabeprazole beads has done by drug layering process and barrier coated beads by providing an enteric coating membrane on IR beads. Timed release beads has done by providing a Film coating for IR and lag time coating for TPR (Timed, Pulsatile Release)  on enteric coated beads. Encapsulation Process and evaluation of enteric coated IR and TPR beads has done by physical evaluation and chemical evaluation. Stability studies have done for best quality Rabeprazole IR and TPR enteric coated beads formulations. Based on the results Formulation 3 and Formulation 9 were selected as the best formulation developed for Rabeprazole Dual Drug Release Capsules.

RASA Life Science Informatics, a Bio-Chemoinformatics company based in Pune, provides unmatchable training facilities to students and professionals in Life Science Informatics. We are now launching a 100% Job oriented Training program, Academic & Industrial Projects to enable anyone and everyone to get trained and get placed.

Post: Business Development Executive

BRAWN, with its inception barely 21 years back(1988) has today evolved into a fully integrated, healthcare group, marking its presence in India and dotting various major markets across the globe. With its claim of quality and certified with ISO 9001:2000, 13485, WHO : cGMP, BRAWN is proud to possess product registration with major health and govt. institutions throughout India and in many other countries worldwide.

Processing over 10 million tests a year, catering to more than 10,000 Laboratories, Hospitals, Nursing homes and 20,000 Consultants; and with 29 years of experience delivering accurate reports, Metropolis has also earned the reputation of being Indias only multinational chain of diagnostic centers with presence in the UAE, Sri Lanka, Mauritius, Bangladesh, Nepal and South Africa.

About Authors:
Pritesh R. Patel^*, Priyank Patel, Jagath Pillai, Nilesh Darji, Bhagirath Patel
Department of Pharmaceutical Chemistry,
Sat Kaival College of Pharmacy, Sarsa,
Ta & Dist: Anand (Gujarat), India-388365
*prit.pharma@gmail.com

ABSTRACT
As part of ongoing studies in developing new antimicrobials, a novel series of 4-acetamido-N-(substituted 1, 3-benzothiazol-2-yl) benzenesulphonamide and N-(substituted 1, 3-benzothiazol-2-yl)-4-(substituted aryl diazenyl) benzenesulphonamide were synthesized in order to determine their antibacterial and antifungal activity. The synthesized compounds were tested in vitro against two Gram-positive bacteria like Staphylococcus aureus, Bacillus subtilis; two Gram-negative bacteria like Escherichia coli, Pseudomonas aeruginosaand one fungal strain Candida albicans in comparison with standard drugs. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antibacterial and antifungal activity against the tested microorganisms. The compounds with a 6-chloro (SK5b), 7-chloro-6-fluoro(SK5d) and 6-nitro (SK5e) on 2-amino benzothiazole ring possessing azo linkage showed better antimicrobial activity; almost similar or less to that of standard drugs thus they could be promising candidates for novel drugs. The novel heterocyclic derivatives were characterized by Physical characterization (Melting point, TLC) and different Spectroscopy techniques (IR, ¹H NMR and Mass spectroscopy).

Atul Ltd is a member of Lalbhai Group, one of the oldest business houses of India, with interests mainly in textiles and chemicals. The Group is strongly committed to serve the society in the fields of education, health as well as culture.

Pegasus Farmaco India Pvt Ltd is a quality driven pharmaceutical manufacturing and marketing company with an over a period of 16 years. Pegasus Farmaco has two state of the art manufacturing units for manufacturing quality formulations in Tablets, Capsules, Ointments forms. Apart from its ethical marketing of its own brands with an established marketing and distribution setup, the company has also rich experience in offering Contract manufacturing Services.

About Authors:
Rakesh Bhatia*
School of Pharmaceutical Sciences,
Department of Pharmaceutical Chemistry,
Jaipur National University,
Jaipur-302025 (Rajasthan), India
*rakesh.mpharm1304@yahoo.com

Abstract
Chemical synthesis data and their biological screening have provided a vast amount of experimental data. As a result of that, availability of large amount of biological data information through molecular biology has made drug discovery and development a more complex method. To combat these problems, Quantitative structure-activity relationships (QSAR) emerged as a very useful tool in drug design. QSAR has been applied extensively and successfully over several decades to find predictive models for activity of bioactive agents. QSAR have brought revolution in drug discovery process by thedevelopment of mathematicalrelationships linking chemical structures and pharmacological activity in quantitative manner of series of compounds. Description of the molecular structure, electronic orbital reactivity and the role of structural and steric components has been the subject of mathematical and statistical analysis. Computational drug design method in QSAR is a rapidly growing field which is now a very important component in the discipline of medicinal chemistry. Virtual filtering and screening of combinatorial libraries have recently gained attention as methods complimenting the high-throughput screening and combinatorial chemistry. These chemoinformatic techniques rely heavily on quantitative structure-activity relationships (QSAR) analysis, a field with established methodology and successful history.By characterize a specific aspect of a molecule that is numbers containing structural information derived from the structural representation used for molecules under study called “Molecular descriptors” to find appropriate representations of the molecular structure of drug compoundsto obtain the structure-activity relationships in which these theoretical and computational methods are based, the ability to predict physicochemical, pharmacokinetic and toxicological properties of these leads are becoming increasingly important in reducing the number of expensive methods and late development failures. Thus thereby, QSAR certainly decreases the number of compounds to be synthesized by easing the selection of the most promising candidates. This review seeks to provide a review on role of molecular descriptors in the drug design in QSAR.